{"id":5472,"date":"2021-02-25T14:36:00","date_gmt":"2021-02-25T12:36:00","guid":{"rendered":"https:\/\/bsicos-dev.i3a.es\/?p=5472"},"modified":"2023-09-12T14:37:35","modified_gmt":"2023-09-12T12:37:35","slug":"monitoring-blood-potassium-concentration-in-hemodialysis-patients-by-quantifying-t-wave-morphology-dynamics","status":"publish","type":"post","link":"https:\/\/bsicos.i3a.es\/es\/monitoring-blood-potassium-concentration-in-hemodialysis-patients-by-quantifying-t-wave-morphology-dynamics\/","title":{"rendered":"Monitoring Blood Potassium Concentration in Hemodialysis Patients by Quantifying T-wave Morphology Dynamics"},"content":{"rendered":"
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    News<\/a><\/h3>\n

    Monitoring Blood Potassium Concentration in Hemodialysis Patients by Quantifying T-wave Morphology Dynamics\n<\/strong><\/h1>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t<\/ul>\t\t\t\t
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      25 Feb, 2021<\/em><\/strong><\/p>\n

      We investigated the ability of time-warping-based ECG-derived markers of T-wave morphology changes in time (dw) and amplitude (da), as well as their non-linear components (dNLw and dNLa), and the\u00a0heart rate<\/strong>\u00a0corrected counterpart (dw,c), to monitor potassium concentration ([K+]) changes (\u0394[K+]) in end-stage\u00a0renal disease<\/strong>\u00a0(ESRD)\u00a0patients<\/strong>\u00a0undergoing\u00a0hemodialysis<\/strong>\u00a0(HD).<\/p>\n

      We compared the performance of the proposed time-warping markers, together with other previously proposed [K+] markers, such as T-wave width (Tw) and T-wave slope-to-amplitude ratio (TS\/A), when computed from standard\u00a0ECG<\/strong>\u00a0leads as well as from principal component analysis (PCA)-based leads. 48-hour ECG recordings and a set of hourly-collected\u00a0blood samples<\/strong>\u00a0from 29 ESRD-HD patients were acquired. Values of dw, da, dNLw , dNLa and dw,c were calculated by comparing the morphology of the mean warped T-waves (MWTWs) derived at each hour along the HD with that from a reference MWTW, measured at the end of the HD. From the same MWTWs Tw and TS\/A were also extracted. Similarly, \u0394[K+] was calculated as the difference between the [K+] values at each hour and the [K+] reference level at the end of the HD session.<\/p>\n

      We found that dw and dw,c showed\u00a0higher correlation coefficients<\/strong>\u00a0with \u0394[K+] than TS\/A\u2014Spearman\u2019s (\u03c1) and Pearson\u2019s (r)\u2014and Tw\u2014Spearman\u2019s (\u03c1)\u2014in both SL and PCA approaches being the intra-patient median \u03c1 \u2265 0.82 and r \u2265 0.87 in SL and \u03c1 \u2265 0.82 and r \u2265 0.89 in PCA respectively.<\/p>\n

      Our findings would point at dw and dw,c as the most suitable surrogate of \u0394[K+], suggesting that they could be potentially useful for\u00a0non-invasive monitoring<\/strong>\u00a0of ESRD-HD patients in hospital,<\/strong>\u00a0as well as in ambulatory settings. Therefore, the tracking of T-wave morphology variations by means of time-warping analysis could improve continuous and remote [K+] monitoring of ESRD-HD patients and fagging risk of [K+]-related\u00a0cardiovascular events.<\/strong><\/p>\n

      F. Palmieri, P. Gomis, D. Ferreira, J. E. Ruiz, B. Bergasa, A. Mart\u00edn-Yebra, H. A. Bukhari, E. Pueyo, J. P. Mart\u00ednez, J. Ram\u00edrez, and P. Laguna (2021)<\/p>\n

      DOI: 10.1038\/s41598-021-82935-5<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>\n\n

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      <\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":3888,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[221],"tags":[220,214],"class_list":["post-5472","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-aragon","tag-i3a"],"_links":{"self":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5472","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/comments?post=5472"}],"version-history":[{"count":1,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5472\/revisions"}],"predecessor-version":[{"id":5473,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5472\/revisions\/5473"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/media\/3888"}],"wp:attachment":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/media?parent=5472"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/categories?post=5472"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/tags?post=5472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}