{"id":5684,"date":"2023-09-27T14:40:14","date_gmt":"2023-09-27T12:40:14","guid":{"rendered":"https:\/\/bsicos-dev.i3a.es\/?p=5684"},"modified":"2023-09-27T14:40:15","modified_gmt":"2023-09-27T12:40:15","slug":"computational-investigation-of-cardiac-arrhythmias-and-drug-effect-from-ion-channels-to-the-surface-electrocardiogram","status":"publish","type":"post","link":"https:\/\/bsicos.i3a.es\/es\/computational-investigation-of-cardiac-arrhythmias-and-drug-effect-from-ion-channels-to-the-surface-electrocardiogram\/","title":{"rendered":"Computational investigation of cardiac arrhythmias and drug effect: from ion channels to the surface electrocardiogram"},"content":{"rendered":"<p><style>\/*! elementor - v3.5.5 - 03-02-2022 *\/<br \/>\n@media (min-width:768px){.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-wrapper,.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-wrapper{display:-webkit-box;display:-ms-flexbox;display:flex}.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-icon,.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-icon{display:-webkit-inline-box;display:-ms-inline-flexbox;display:inline-flex;-webkit-box-flex:0;-ms-flex:0 0 auto;flex:0 0 auto}.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-wrapper{text-align:right;-webkit-box-orient:horizontal;-webkit-box-direction:reverse;-ms-flex-direction:row-reverse;flex-direction:row-reverse}.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-wrapper{text-align:left;-webkit-box-orient:horizontal;-webkit-box-direction:normal;-ms-flex-direction:row;flex-direction:row}.elementor-widget-icon-box.elementor-position-top .elementor-icon-box-img{margin:auto}.elementor-widget-icon-box.elementor-vertical-align-top .elementor-icon-box-wrapper{-webkit-box-align:start;-ms-flex-align:start;align-items:flex-start}.elementor-widget-icon-box.elementor-vertical-align-middle .elementor-icon-box-wrapper{-webkit-box-align:center;-ms-flex-align:center;align-items:center}.elementor-widget-icon-box.elementor-vertical-align-bottom .elementor-icon-box-wrapper{-webkit-box-align:end;-ms-flex-align:end;align-items:flex-end}}@media (max-width:767px){.elementor-widget-icon-box .elementor-icon-box-icon{margin-left:auto!important;margin-right:auto!important;margin-bottom:15px}}.elementor-widget-icon-box .elementor-icon-box-wrapper{text-align:center}.elementor-widget-icon-box .elementor-icon-box-title a{color:inherit}.elementor-widget-icon-box .elementor-icon-box-content{-webkit-box-flex:1;-ms-flex-positive:1;flex-grow:1}.elementor-widget-icon-box .elementor-icon-box-description{margin:0}<\/style><\/p>\n\n\n<div id=\"pl-gb5684-69e9532f9573d\"  class=\"panel-layout\" ><div id=\"pg-gb5684-69e9532f9573d-0\"  class=\"panel-grid panel-has-style\" ><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-gb5684-69e9532f9573d-0\" data-stretch-type=\"full-width-stretch\" ><div id=\"pgc-gb5684-69e9532f9573d-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5684-69e9532f9573d-0-0-0\" class=\"so-panel widget widget_sow-hero panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-hero so-widget-sow-hero-default-93415d0e2dbf-5684 so-widget-fittext-wrapper\"\n\t\t\t data-fit-text-compressor=\"0.85\"\n\t\t>\t\t\t\t<div class=\"sow-slider-base\" style=\"display: none\" tabindex=\"0\">\n\t\t\t\t\t<ul\n\t\t\t\t\tclass=\"sow-slider-images\"\n\t\t\t\t\tdata-settings=\"{&quot;pagination&quot;:true,&quot;speed&quot;:800,&quot;timeout&quot;:8000,&quot;paused&quot;:false,&quot;pause_on_hover&quot;:false,&quot;swipe&quot;:true,&quot;nav_always_show_desktop&quot;:&quot;&quot;,&quot;nav_always_show_mobile&quot;:&quot;&quot;,&quot;breakpoint&quot;:&quot;780px&quot;,&quot;unmute&quot;:false,&quot;anchor&quot;:null}\"\n\t\t\t\t\t\t\t\t\t\tdata-anchor-id=\"\"\n\t\t\t\t>\t\t<li class=\"sow-slider-image\" style=\"visibility: visible;;background-color: #1e73be\" >\n\t\t\t\t\t<div class=\"sow-slider-image-container\">\n\t\t\t<div class=\"sow-slider-image-wrapper\">\n\t\t\t\t<h3 style=\"text-align: center\"><a href=\"..\/all-projects\/\">Proyectos<\/a><\/h3>\n<h1 class=\"entry-title\" style=\"text-align: center\"><strong>Computational investigation of cardiac arrhythmias and drug effect: from ion channels to the surface electrocardiogram\n<\/strong><\/h1>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t<\/ul>\t\t\t\t<ol class=\"sow-slider-pagination\">\n\t\t\t\t\t\t\t\t\t\t\t<li><a href=\"#\" data-goto=\"0\" aria-label=\"mostrar diapositiva 1\"><\/a><\/li>\n\t\t\t\t\t\t\t\t\t<\/ol>\n\n\t\t\t\t<div class=\"sow-slide-nav sow-slide-nav-next\">\n\t\t\t\t\t<a href=\"#\" data-goto=\"next\" aria-label=\"diapositiva siguiente\" data-action=\"next\">\n\t\t\t\t\t\t<em class=\"sow-sld-icon-thin-right\"><\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\n\t\t\t\t<div class=\"sow-slide-nav sow-slide-nav-prev\">\n\t\t\t\t\t<a href=\"#\" data-goto=\"previous\" aria-label=\"diapositiva anterior\" data-action=\"prev\">\n\t\t\t\t\t\t<em class=\"sow-sld-icon-thin-left\"><\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\n<div id=\"pl-gb5684-69e9532f962d6\"  class=\"panel-layout\" ><div id=\"pg-gb5684-69e9532f962d6-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-gb5684-69e9532f962d6-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5684-69e9532f962d6-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Fecha de inicio<\/strong><\/p>\n<p style=\"text-align: center;\">2011<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-gb5684-69e9532f962d6-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5684-69e9532f962d6-0-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Fecha de finalizaci\u00f3n<\/strong><\/p>\n<p style=\"text-align: center;\">2014<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-gb5684-69e9532f962d6-0-2\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5684-69e9532f962d6-0-2-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Coordinador<\/strong><\/p>\n<p style=\"text-align: center;\">Esther Pueyo<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-gb5684-69e9532f962d6-0-3\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5684-69e9532f962d6-0-3-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"3\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Funding agency<\/strong><\/p>\n<p style=\"text-align: center;\">MICINN, TEC2010-19410<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-gb5684-69e9532f962d6-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-gb5684-69e9532f962d6-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5684-69e9532f962d6-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"4\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<hr \/>\n<section class=\"kc-elm kc-css-683516 kc_row\">\n<div class=\"kc-row-container kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-158099 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-693042 kc_text_block\">\n<p>The electrocardiogram (ECG) is the clinical test routinely used to diagnose and treat cardiac disorders. Despite the fact that many diagnostic and therapeutic decisions rely only upon interpretation of ECG patterns, the cellular and sub-cellular mechanisms underlying pathophysiological ECG changes remain mostly unclear. In this project we specifically aim at improving the currently existing knowledge of the mechanisms responsible for the generation and maintenance of cardiac arrhythmias, as well as of therapeutic approaches to prevent or terminate them. We propose to use a multi-scale approach that will enable us to characterize abnormalities from the ion channel level to the ECG as well as to determine the effects of pharmacological compounds on those abnormalities, both at preclinical and clinical stages. Specifically, we will develop and validate whole atrial and ventricular computational models and we will use them to simulate the electrical activity of the heart from the single cell to the whole cavity and, ultimately, to the ECG. Development and validation of the models will be based on available experimental and clinical data. Simulations will be run to investigate the causes and mechanisms responsible for the occurrence of cardiac arrhythmias. Pharmacological modeling and testing will also be conducted as part of the project, and hints for the development of new compounds will be provided.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"kc-elm kc-css-384056 kc_row\">\n<div class=\"kc-row-container kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-669673 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[274,267,266,272,276,264],"tags":[],"class_list":["post-5684","post","type-post","status-publish","format-standard","hentry","category-non-invasive-ecg-indices-finished","category-autonomic-nervous-system-finished","category-lines-finished","category-modeling-finished","category-national-projects-finished","category-projects-finished"],"_links":{"self":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/comments?post=5684"}],"version-history":[{"count":1,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5684\/revisions"}],"predecessor-version":[{"id":5685,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5684\/revisions\/5685"}],"wp:attachment":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/media?parent=5684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/categories?post=5684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/tags?post=5684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}