{"id":5686,"date":"2023-09-27T14:42:00","date_gmt":"2023-09-27T12:42:00","guid":{"rendered":"https:\/\/bsicos-dev.i3a.es\/?p=5686"},"modified":"2023-09-27T14:42:00","modified_gmt":"2023-09-27T12:42:00","slug":"qt-bed-evaluation-of-changes-in-ventricular-repolarization-and-its-relationship-with-heart-rate-during-bed-rest-experiments","status":"publish","type":"post","link":"https:\/\/bsicos.i3a.es\/es\/qt-bed-evaluation-of-changes-in-ventricular-repolarization-and-its-relationship-with-heart-rate-during-bed-rest-experiments\/","title":{"rendered":"QT-bed: Evaluation of changes in ventricular repolarization and its relationship with heart rate during bed-rest experiments"},"content":{"rendered":"<p><style>\/*! elementor - v3.5.5 - 03-02-2022 *\/<br \/>\n@media (min-width:768px){.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-wrapper,.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-wrapper{display:-webkit-box;display:-ms-flexbox;display:flex}.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-icon,.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-icon{display:-webkit-inline-box;display:-ms-inline-flexbox;display:inline-flex;-webkit-box-flex:0;-ms-flex:0 0 auto;flex:0 0 auto}.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-wrapper{text-align:right;-webkit-box-orient:horizontal;-webkit-box-direction:reverse;-ms-flex-direction:row-reverse;flex-direction:row-reverse}.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-wrapper{text-align:left;-webkit-box-orient:horizontal;-webkit-box-direction:normal;-ms-flex-direction:row;flex-direction:row}.elementor-widget-icon-box.elementor-position-top .elementor-icon-box-img{margin:auto}.elementor-widget-icon-box.elementor-vertical-align-top .elementor-icon-box-wrapper{-webkit-box-align:start;-ms-flex-align:start;align-items:flex-start}.elementor-widget-icon-box.elementor-vertical-align-middle .elementor-icon-box-wrapper{-webkit-box-align:center;-ms-flex-align:center;align-items:center}.elementor-widget-icon-box.elementor-vertical-align-bottom .elementor-icon-box-wrapper{-webkit-box-align:end;-ms-flex-align:end;align-items:flex-end}}@media (max-width:767px){.elementor-widget-icon-box .elementor-icon-box-icon{margin-left:auto!important;margin-right:auto!important;margin-bottom:15px}}.elementor-widget-icon-box .elementor-icon-box-wrapper{text-align:center}.elementor-widget-icon-box .elementor-icon-box-title a{color:inherit}.elementor-widget-icon-box .elementor-icon-box-content{-webkit-box-flex:1;-ms-flex-positive:1;flex-grow:1}.elementor-widget-icon-box .elementor-icon-box-description{margin:0}<\/style><\/p>\n\n\n<div id=\"pl-gb5686-69d9d70e1f8b7\"  class=\"panel-layout\" ><div id=\"pg-gb5686-69d9d70e1f8b7-0\"  class=\"panel-grid panel-has-style\" ><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-gb5686-69d9d70e1f8b7-0\" data-stretch-type=\"full-width-stretch\" ><div id=\"pgc-gb5686-69d9d70e1f8b7-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5686-69d9d70e1f8b7-0-0-0\" class=\"so-panel widget widget_sow-hero panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-hero so-widget-sow-hero-default-93415d0e2dbf-5686 so-widget-fittext-wrapper\"\n\t\t\t data-fit-text-compressor=\"0.85\"\n\t\t>\t\t\t\t<div class=\"sow-slider-base\" style=\"display: none\" tabindex=\"0\">\n\t\t\t\t\t<ul\n\t\t\t\t\tclass=\"sow-slider-images\"\n\t\t\t\t\tdata-settings=\"{&quot;pagination&quot;:true,&quot;speed&quot;:800,&quot;timeout&quot;:8000,&quot;paused&quot;:false,&quot;pause_on_hover&quot;:false,&quot;swipe&quot;:true,&quot;nav_always_show_desktop&quot;:&quot;&quot;,&quot;nav_always_show_mobile&quot;:&quot;&quot;,&quot;breakpoint&quot;:&quot;780px&quot;,&quot;unmute&quot;:false,&quot;anchor&quot;:null}\"\n\t\t\t\t\t\t\t\t\t\tdata-anchor-id=\"\"\n\t\t\t\t>\t\t<li class=\"sow-slider-image\" style=\"visibility: visible;;background-color: #1e73be\" >\n\t\t\t\t\t<div class=\"sow-slider-image-container\">\n\t\t\t<div class=\"sow-slider-image-wrapper\">\n\t\t\t\t<h3 style=\"text-align: center\"><a href=\"..\/all-projects\/\">Proyectos<\/a><\/h3>\n<h1 class=\"entry-title\" style=\"text-align: center\"><strong>QT-bed: Evaluation of changes in ventricular repolarization and its relationship with heart rate during bed-rest experiments\n<\/strong><\/h1>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t<\/ul>\t\t\t\t<ol class=\"sow-slider-pagination\">\n\t\t\t\t\t\t\t\t\t\t\t<li><a href=\"#\" data-goto=\"0\" aria-label=\"mostrar diapositiva 1\"><\/a><\/li>\n\t\t\t\t\t\t\t\t\t<\/ol>\n\n\t\t\t\t<div class=\"sow-slide-nav sow-slide-nav-next\">\n\t\t\t\t\t<a href=\"#\" data-goto=\"next\" aria-label=\"diapositiva siguiente\" data-action=\"next\">\n\t\t\t\t\t\t<em class=\"sow-sld-icon-thin-right\"><\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\n\t\t\t\t<div class=\"sow-slide-nav sow-slide-nav-prev\">\n\t\t\t\t\t<a href=\"#\" data-goto=\"previous\" aria-label=\"diapositiva anterior\" data-action=\"prev\">\n\t\t\t\t\t\t<em class=\"sow-sld-icon-thin-left\"><\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\n<div id=\"pl-gb5686-69d9d70e20447\"  class=\"panel-layout\" ><div id=\"pg-gb5686-69d9d70e20447-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-gb5686-69d9d70e20447-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5686-69d9d70e20447-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Fecha de inicio<\/strong><\/p>\n<p style=\"text-align: center;\">2011<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-gb5686-69d9d70e20447-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5686-69d9d70e20447-0-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Fecha de finalizaci\u00f3n<\/strong><\/p>\n<p style=\"text-align: center;\">2015<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-gb5686-69d9d70e20447-0-2\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5686-69d9d70e20447-0-2-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Coordinador<\/strong><\/p>\n<p style=\"text-align: center;\">Pablo Laguna<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-gb5686-69d9d70e20447-0-3\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5686-69d9d70e20447-0-3-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"3\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Funding agency<\/strong><\/p>\n<p style=\"text-align: center;\">ESA (ref. AO-09-BR)<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-gb5686-69d9d70e20447-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-gb5686-69d9d70e20447-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5686-69d9d70e20447-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"4\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<hr \/>\n<section class=\"kc-elm kc-css-683516 kc_row\">\n<div class=\"kc-row-container kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-158099 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-693042 kc_text_block\">\n<section class=\"kc-elm kc-css-25265 kc_row\">\n<div class=\"kc-row-container  kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-892141 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-489482 kc_text_block\">\n<p>Previous studies showed that astronauts\u00a0suffer\u00a0from\u00a0<wbr \/>misalignment\u00a0of\u00a0sleep\u00a0and\u00a0<wbr \/>circadian\u00a0rhythms\u00a0during\u00a0 spaceflight,\u00a0with\u00a0possible\u00a0<wbr \/>impairments\u00a0of\u00a0health,\u00a0<wbr \/>alertness,\u00a0and\u00a0performance.\u00a0<wbr \/>Besides\u00a0anecdotal\u00a0data\u00a0exist\u00a0 on\u00a0the\u00a0possible\u00a0increased risk\u00a0of\u00a0cardiac\u00a0dysrhythmias\u00a0<wbr \/>during\u00a0spaceflight,\u00a0a\u00a0first\u00a0<wbr \/>mechanistic\u00a0link\u00a0between\u00a0 endogenous\u00a0circadian\u00a0rhythms\u00a0<wbr \/>and\u00a0cardiac\u00a0electrical\u00a0<wbr \/>instability\u00a0through\u00a0changes\u00a0<wbr \/>in\u00a0QT\u00a0duration,\u00a0most\u00a0often\u00a0 associated\u00a0with\u00a0sudden\u00a0<wbr \/>cardiac\u00a0death\u00a0in\u00a0humans,\u00a0has\u00a0<wbr \/>been\u00a0demonstrated\u00a0in\u00a0an\u00a0<wbr \/>animal\u00a0model.\u00a0In\u00a0addition,\u00a0 our\u00a0results\u00a0from\u00a0previous\u00a0bed\u00a0<wbr \/>rest\u00a0studies\u00a0showed\u00a0an\u00a0<wbr \/>increase\u00a0in\u00a0ventricular\u00a0<wbr \/>repolarization\u00a0heterogeneity,\u00a0 in\u00a0particular\u00a0when\u00a0a\u00a0<wbr \/>gravitational\u00a0field\u00a0is\u00a0<wbr \/>restored\u00a0after\u00a060\u00a0days\u00a0of\u00a0<wbr \/>head\u2010down\u00a0bed\u00a0rest,\u00a0that\u00a0<wbr \/>underline\u00a0the\u00a0 possibility\u00a0of\u00a0increased\u00a0risk\u00a0<wbr \/>of\u00a0developing\u00a0arrhythmias.\u00a0<wbr \/>These\u00a0findings\u00a0could\u00a0result\u00a0<wbr \/>crucial\u00a0in\u00a0the\u00a0design\u00a0of\u00a0 long\u2010duration\u00a0space\u00a0missions\u00a0(<wbr \/>Moon\u00a0or\u00a0Mars)\u00a0where,\u00a0after\u00a0a\u00a0<wbr \/>long\u00a0period\u00a0of\u00a0weightlessness\u00a0<wbr \/>exposure\u00a0in\u00a0 which\u00a0also\u00a0the\u00a0effect\u00a0of\u00a0<wbr \/>radiations\u00a0on\u00a0myocardial\u00a0<wbr \/>structure\u00a0should\u00a0be\u00a0<wbr \/>considered,\u00a0the\u00a0astronauts\u00a0<wbr \/>will\u00a0be\u00a0reexposed\u00a0to\u00a0a\u00a0<wbr \/>gravitational\u00a0field\u00a0when\u00a0<wbr \/>landing\u00a0on\u00a0the\u00a0planet.\u00a0 Accordingly,\u00a0our\u00a0proposal\u00a0is\u00a0<wbr \/>focused\u00a0on\u00a0studying,\u00a0by\u00a0<wbr \/>application\u00a0of\u00a0advanced\u00a0<wbr \/>signal\u00a0processing\u00a0algorithms\u00a0<wbr \/>to\u00a0 longitudinal\u00a0ECG\u00a0Holter\u00a024h\u00a0<wbr \/>acquisitions\u00a0the\u00a0effects\u00a0of\u00a0<wbr \/>long\u2010term\u00a0bed\u00a0rest\u00a0in:\u00a01)\u00a0<wbr \/>circadian\u00a0rhythms\u00a0of\u00a0cardiac\u00a0 electrical\u00a0activity;\u00a02)\u00a0<wbr \/>ventricular\u00a0repolarization\u00a0<wbr \/>instability,\u00a0that\u00a0could\u00a0also\u00a0<wbr \/>be\u00a0related\u00a0to\u00a0the\u00a0resulting\u00a0<wbr \/>rhythms\u00a0 misalignment.\u00a0\u00a0 In\u00a0addition,\u00a0the\u00a0effects\u00a0of\u00a0<wbr \/>the\u00a0proposed\u00a0countermeasures\u00a0(<wbr \/>artificial\u00a0gravity\u00a0with\u00a0or\u00a0<wbr \/>without\u00a0exercise),\u00a0in\u00a0 normobaric\u00a0normoxia\u00a0or\u00a0<wbr \/>hypoxia\u00a0environment,\u00a0will\u00a0be\u00a0<wbr \/>evaluated\u00a0on\u00a0the\u00a0computed\u00a0<wbr \/>parameters.\u00a0\u00a0 Obtained\u00a0data\u00a0in\u00a0control\u00a0<wbr \/>groups\u00a0will\u00a0also\u00a0be\u00a0pooled\u00a0<wbr \/>together\u00a0with\u00a0previous\u00a0data\u00a0<wbr \/>we\u00a0obtained\u00a0in\u00a0the\u00a0same\u00a0 condition\u00a0from\u00a0two\u00a060\u2010days\u00a0<wbr \/>head\u2010down\u00a0tilt\u00a0(HDT)\u00a0bed\u00a0rest\u00a0<wbr \/>campaigns\u00a0(COCKTAIL\u00a0at\u00a0MEDES,\u00a0<wbr \/>and\u00a0RLS\u00a0at\u00a0DLR)\u00a0 to\u00a0increase\u00a0statistical\u00a0<wbr \/>significance of the results<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"kc-elm kc-css-384056 kc_row\">\n<div class=\"kc-row-container kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-669673 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[274,267,265,266,264],"tags":[],"class_list":["post-5686","post","type-post","status-publish","format-standard","hentry","category-non-invasive-ecg-indices-finished","category-autonomic-nervous-system-finished","category-international-projects-finished","category-lines-finished","category-projects-finished"],"_links":{"self":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5686","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/comments?post=5686"}],"version-history":[{"count":1,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5686\/revisions"}],"predecessor-version":[{"id":5687,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5686\/revisions\/5687"}],"wp:attachment":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/media?parent=5686"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/categories?post=5686"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/tags?post=5686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}