{"id":5691,"date":"2023-09-27T14:52:47","date_gmt":"2023-09-27T12:52:47","guid":{"rendered":"https:\/\/bsicos-dev.i3a.es\/?p=5691"},"modified":"2023-09-27T14:52:48","modified_gmt":"2023-09-27T12:52:48","slug":"the-autonomous-nervous-system-as-a-modulator-of-cardiac-function-comprehensive-investigation-through-signal-processing-and-computational-modeling","status":"publish","type":"post","link":"https:\/\/bsicos.i3a.es\/es\/the-autonomous-nervous-system-as-a-modulator-of-cardiac-function-comprehensive-investigation-through-signal-processing-and-computational-modeling\/","title":{"rendered":"The Autonomous Nervous System as a modulator of cardiac function: comprehensive investigation through signal processing and computational modeling"},"content":{"rendered":"<p><style>\/*! elementor - v3.5.5 - 03-02-2022 *\/<br \/>\n@media (min-width:768px){.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-wrapper,.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-wrapper{display:-webkit-box;display:-ms-flexbox;display:flex}.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-icon,.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-icon{display:-webkit-inline-box;display:-ms-inline-flexbox;display:inline-flex;-webkit-box-flex:0;-ms-flex:0 0 auto;flex:0 0 auto}.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-wrapper{text-align:right;-webkit-box-orient:horizontal;-webkit-box-direction:reverse;-ms-flex-direction:row-reverse;flex-direction:row-reverse}.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-wrapper{text-align:left;-webkit-box-orient:horizontal;-webkit-box-direction:normal;-ms-flex-direction:row;flex-direction:row}.elementor-widget-icon-box.elementor-position-top .elementor-icon-box-img{margin:auto}.elementor-widget-icon-box.elementor-vertical-align-top .elementor-icon-box-wrapper{-webkit-box-align:start;-ms-flex-align:start;align-items:flex-start}.elementor-widget-icon-box.elementor-vertical-align-middle .elementor-icon-box-wrapper{-webkit-box-align:center;-ms-flex-align:center;align-items:center}.elementor-widget-icon-box.elementor-vertical-align-bottom .elementor-icon-box-wrapper{-webkit-box-align:end;-ms-flex-align:end;align-items:flex-end}}@media (max-width:767px){.elementor-widget-icon-box .elementor-icon-box-icon{margin-left:auto!important;margin-right:auto!important;margin-bottom:15px}}.elementor-widget-icon-box .elementor-icon-box-wrapper{text-align:center}.elementor-widget-icon-box .elementor-icon-box-title a{color:inherit}.elementor-widget-icon-box .elementor-icon-box-content{-webkit-box-flex:1;-ms-flex-positive:1;flex-grow:1}.elementor-widget-icon-box .elementor-icon-box-description{margin:0}<\/style><\/p>\n\n\n<div id=\"pl-gb5691-69e9516e7f2eb\"  class=\"panel-layout\" ><div id=\"pg-gb5691-69e9516e7f2eb-0\"  class=\"panel-grid panel-has-style\" ><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-gb5691-69e9516e7f2eb-0\" data-stretch-type=\"full-width-stretch\" ><div id=\"pgc-gb5691-69e9516e7f2eb-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5691-69e9516e7f2eb-0-0-0\" class=\"so-panel widget widget_sow-hero panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-hero so-widget-sow-hero-default-93415d0e2dbf-5691 so-widget-fittext-wrapper\"\n\t\t\t data-fit-text-compressor=\"0.85\"\n\t\t>\t\t\t\t<div class=\"sow-slider-base\" style=\"display: none\" tabindex=\"0\">\n\t\t\t\t\t<ul\n\t\t\t\t\tclass=\"sow-slider-images\"\n\t\t\t\t\tdata-settings=\"{&quot;pagination&quot;:true,&quot;speed&quot;:800,&quot;timeout&quot;:8000,&quot;paused&quot;:false,&quot;pause_on_hover&quot;:false,&quot;swipe&quot;:true,&quot;nav_always_show_desktop&quot;:&quot;&quot;,&quot;nav_always_show_mobile&quot;:&quot;&quot;,&quot;breakpoint&quot;:&quot;780px&quot;,&quot;unmute&quot;:false,&quot;anchor&quot;:null}\"\n\t\t\t\t\t\t\t\t\t\tdata-anchor-id=\"\"\n\t\t\t\t>\t\t<li class=\"sow-slider-image\" style=\"visibility: visible;;background-color: #1e73be\" >\n\t\t\t\t\t<div class=\"sow-slider-image-container\">\n\t\t\t<div class=\"sow-slider-image-wrapper\">\n\t\t\t\t<h3 style=\"text-align: center\"><a href=\"..\/all-projects\/\">Proyectos<\/a><\/h3>\n<h1 class=\"entry-title\" style=\"text-align: center\"><strong>The Autonomous Nervous System as a modulator of cardiac function: comprehensive investigation through signal processing and computational modeling\n<\/strong><\/h1>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t<\/ul>\t\t\t\t<ol class=\"sow-slider-pagination\">\n\t\t\t\t\t\t\t\t\t\t\t<li><a href=\"#\" data-goto=\"0\" aria-label=\"mostrar diapositiva 1\"><\/a><\/li>\n\t\t\t\t\t\t\t\t\t<\/ol>\n\n\t\t\t\t<div class=\"sow-slide-nav sow-slide-nav-next\">\n\t\t\t\t\t<a href=\"#\" data-goto=\"next\" aria-label=\"diapositiva siguiente\" data-action=\"next\">\n\t\t\t\t\t\t<em class=\"sow-sld-icon-thin-right\"><\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\n\t\t\t\t<div class=\"sow-slide-nav sow-slide-nav-prev\">\n\t\t\t\t\t<a href=\"#\" data-goto=\"previous\" aria-label=\"diapositiva anterior\" data-action=\"prev\">\n\t\t\t\t\t\t<em class=\"sow-sld-icon-thin-left\"><\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\n<div id=\"pl-gb5691-69e9516e7fdd3\"  class=\"panel-layout\" ><div id=\"pg-gb5691-69e9516e7fdd3-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-gb5691-69e9516e7fdd3-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5691-69e9516e7fdd3-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Fecha de inicio<\/strong><\/p>\n<p style=\"text-align: center;\">2014<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-gb5691-69e9516e7fdd3-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5691-69e9516e7fdd3-0-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Fecha de finalizaci\u00f3n<\/strong><\/p>\n<p style=\"text-align: center;\">2016<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-gb5691-69e9516e7fdd3-0-2\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5691-69e9516e7fdd3-0-2-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Coordinador<\/strong><\/p>\n<p style=\"text-align: center;\">Esther Pueyo<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-gb5691-69e9516e7fdd3-0-3\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5691-69e9516e7fdd3-0-3-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"3\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Funding agency<\/strong><\/p>\n<p style=\"text-align: center;\">MINECO, TIN2013-41998-R<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-gb5691-69e9516e7fdd3-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-gb5691-69e9516e7fdd3-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5691-69e9516e7fdd3-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"4\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<hr \/>\n<section class=\"kc-elm kc-css-683516 kc_row\">\n<div class=\"kc-row-container kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-158099 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-693042 kc_text_block\">\n<section class=\"kc-elm kc-css-720061 kc_row\">\n<div class=\"kc-row-container  kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-911968 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-374135 kc_text_block\">\n<p>The Autonomic Nervous System (ANS) regulates the function of internal organs such as the heart. Experimental and clinical evidences suggest an important participation of the ANS in cardiac arrhythmias. However, the bases for such participation are mainly speculative, which hampers the design of more efficient anti-arrhythmic therapies. In this project we specifically aim at unraveling the ANS participation in arrhythmias related to cardiac diseases such as genetic Long QT syndrome, ischemia and atrial fibrillation and to conditions associated with increased cardiac risk due to competitive sport, microgravity exposure or cardiovascular aging. A methodological framework is set up that will combine processing of biological signals and development of computational models of ANS-heart electrophysiology. Analyzed biological signals will include patch-clamp recordings of ionic currents, action potentials of cell and tissue preparations, intracavitary pressures, electrograms and electrocardiograms. Stochastic computational models will be built to represent variability in human cardiac electrophysiology and ANS regulation. Model development and calibration, in healthy and diseased hearts, will be based on the results of the processed signals.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"kc-elm kc-css-384056 kc_row\">\n<div class=\"kc-row-container kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-669673 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[274,267,266,272,276,264],"tags":[],"class_list":["post-5691","post","type-post","status-publish","format-standard","hentry","category-non-invasive-ecg-indices-finished","category-autonomic-nervous-system-finished","category-lines-finished","category-modeling-finished","category-national-projects-finished","category-projects-finished"],"_links":{"self":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/comments?post=5691"}],"version-history":[{"count":1,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5691\/revisions"}],"predecessor-version":[{"id":5694,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5691\/revisions\/5694"}],"wp:attachment":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/media?parent=5691"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/categories?post=5691"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/tags?post=5691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}