{"id":5806,"date":"2023-10-02T14:26:24","date_gmt":"2023-10-02T12:26:24","guid":{"rendered":"https:\/\/bsicos-dev.i3a.es\/?p=5806"},"modified":"2023-10-02T14:26:25","modified_gmt":"2023-10-02T12:26:25","slug":"human-cardiac-ageing-modeling-and-identification-of-age-related-electrophysiological-markers","status":"publish","type":"post","link":"https:\/\/bsicos.i3a.es\/es\/human-cardiac-ageing-modeling-and-identification-of-age-related-electrophysiological-markers\/","title":{"rendered":"Human cardiac ageing modeling and identification of age related electrophysiological markers"},"content":{"rendered":"<p><style>\/*! elementor - v3.5.5 - 03-02-2022 *\/<br \/>\n@media (min-width:768px){.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-wrapper,.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-wrapper{display:-webkit-box;display:-ms-flexbox;display:flex}.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-icon,.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-icon{display:-webkit-inline-box;display:-ms-inline-flexbox;display:inline-flex;-webkit-box-flex:0;-ms-flex:0 0 auto;flex:0 0 auto}.elementor-widget-icon-box.elementor-position-right .elementor-icon-box-wrapper{text-align:right;-webkit-box-orient:horizontal;-webkit-box-direction:reverse;-ms-flex-direction:row-reverse;flex-direction:row-reverse}.elementor-widget-icon-box.elementor-position-left .elementor-icon-box-wrapper{text-align:left;-webkit-box-orient:horizontal;-webkit-box-direction:normal;-ms-flex-direction:row;flex-direction:row}.elementor-widget-icon-box.elementor-position-top .elementor-icon-box-img{margin:auto}.elementor-widget-icon-box.elementor-vertical-align-top .elementor-icon-box-wrapper{-webkit-box-align:start;-ms-flex-align:start;align-items:flex-start}.elementor-widget-icon-box.elementor-vertical-align-middle .elementor-icon-box-wrapper{-webkit-box-align:center;-ms-flex-align:center;align-items:center}.elementor-widget-icon-box.elementor-vertical-align-bottom .elementor-icon-box-wrapper{-webkit-box-align:end;-ms-flex-align:end;align-items:flex-end}}@media (max-width:767px){.elementor-widget-icon-box .elementor-icon-box-icon{margin-left:auto!important;margin-right:auto!important;margin-bottom:15px}}.elementor-widget-icon-box .elementor-icon-box-wrapper{text-align:center}.elementor-widget-icon-box .elementor-icon-box-title a{color:inherit}.elementor-widget-icon-box .elementor-icon-box-content{-webkit-box-flex:1;-ms-flex-positive:1;flex-grow:1}.elementor-widget-icon-box .elementor-icon-box-description{margin:0}<\/style><\/p>\n\n\n<div id=\"pl-gb5806-69e51f368fcb9\"  class=\"panel-layout\" ><div id=\"pg-gb5806-69e51f368fcb9-0\"  class=\"panel-grid panel-has-style\" ><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-gb5806-69e51f368fcb9-0\" data-stretch-type=\"full-width-stretch\" ><div id=\"pgc-gb5806-69e51f368fcb9-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5806-69e51f368fcb9-0-0-0\" class=\"so-panel widget widget_sow-hero panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-hero so-widget-sow-hero-default-93415d0e2dbf-5806 so-widget-fittext-wrapper\"\n\t\t\t data-fit-text-compressor=\"0.85\"\n\t\t>\t\t\t\t<div class=\"sow-slider-base\" style=\"display: none\" tabindex=\"0\">\n\t\t\t\t\t<ul\n\t\t\t\t\tclass=\"sow-slider-images\"\n\t\t\t\t\tdata-settings=\"{&quot;pagination&quot;:true,&quot;speed&quot;:800,&quot;timeout&quot;:8000,&quot;paused&quot;:false,&quot;pause_on_hover&quot;:false,&quot;swipe&quot;:true,&quot;nav_always_show_desktop&quot;:&quot;&quot;,&quot;nav_always_show_mobile&quot;:&quot;&quot;,&quot;breakpoint&quot;:&quot;780px&quot;,&quot;unmute&quot;:false,&quot;anchor&quot;:null}\"\n\t\t\t\t\t\t\t\t\t\tdata-anchor-id=\"\"\n\t\t\t\t>\t\t<li class=\"sow-slider-image\" style=\"visibility: visible;;background-color: #1e73be\" >\n\t\t\t\t\t<div class=\"sow-slider-image-container\">\n\t\t\t<div class=\"sow-slider-image-wrapper\">\n\t\t\t\t<h3 style=\"text-align: center\"><a href=\"..\/all-projects\/\">Proyectos<\/a><\/h3>\n<h1 class=\"entry-title\" style=\"text-align: center\"><strong>Human cardiac ageing modeling and identification of age related electrophysiological markers\n<\/strong><\/h1>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t<\/ul>\t\t\t\t<ol class=\"sow-slider-pagination\">\n\t\t\t\t\t\t\t\t\t\t\t<li><a href=\"#\" data-goto=\"0\" aria-label=\"mostrar diapositiva 1\"><\/a><\/li>\n\t\t\t\t\t\t\t\t\t<\/ol>\n\n\t\t\t\t<div class=\"sow-slide-nav sow-slide-nav-next\">\n\t\t\t\t\t<a href=\"#\" data-goto=\"next\" aria-label=\"diapositiva siguiente\" data-action=\"next\">\n\t\t\t\t\t\t<em class=\"sow-sld-icon-thin-right\"><\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\n\t\t\t\t<div class=\"sow-slide-nav sow-slide-nav-prev\">\n\t\t\t\t\t<a href=\"#\" data-goto=\"previous\" aria-label=\"diapositiva anterior\" data-action=\"prev\">\n\t\t\t\t\t\t<em class=\"sow-sld-icon-thin-left\"><\/em>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\n<div id=\"pl-gb5806-69e51f3690799\"  class=\"panel-layout\" ><div id=\"pg-gb5806-69e51f3690799-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-gb5806-69e51f3690799-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5806-69e51f3690799-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Fecha de inicio<\/strong><\/p>\n<p style=\"text-align: center;\">2018<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-gb5806-69e51f3690799-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5806-69e51f3690799-0-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Fecha de finalizaci\u00f3n<\/strong><\/p>\n<p style=\"text-align: center;\">2018<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-gb5806-69e51f3690799-0-2\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5806-69e51f3690799-0-2-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Coordinador<\/strong><\/p>\n<p style=\"text-align: center;\">Laura Ordov\u00e1s<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-gb5806-69e51f3690799-0-3\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5806-69e51f3690799-0-3-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"3\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><strong>Funding agency<\/strong><\/p>\n<p style=\"text-align: center;\">CIBERFundaci\u00f3n Ibercaja \/ Universidad de Zaragoza<br \/>\nJIUZ-2017-TEC-07<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-gb5806-69e51f3690799-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-gb5806-69e51f3690799-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-gb5806-69e51f3690799-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"4\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<hr \/>\n<section class=\"kc-elm kc-css-683516 kc_row\">\n<div class=\"kc-row-container kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-158099 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-693042 kc_text_block\">\n<p>The effects of age on the heart are scarcely characterized and there are no relevant models of cardiac aging in the human species. One of the bottlenecks in the study of the main electromechanical changes intrinsically\u00a0associated with age and their molecular mechanisms make it difficult to develop non-invasive tools for the early detection of the risk of suffering arrhythmias and to create new preventive therapies or treatments.<\/p>\n<p>The main objective of this project is to establish a model of human cardiac aging and discover electrophysiological markers associated with age. The in vitro model is based on induced pluripotent stem cells\u00a0(iPSC) with the ability to longitudinally mimic the intrinsic effects of age on electromechanical dysfunction<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"kc-elm kc-css-384056 kc_row\">\n<div class=\"kc-row-container kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-669673 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269,266,272,276,264],"tags":[],"class_list":["post-5806","post","type-post","status-publish","format-standard","hentry","category-in-vitro-modeling-finished","category-lines-finished","category-modeling-finished","category-national-projects-finished","category-projects-finished"],"_links":{"self":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5806","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/comments?post=5806"}],"version-history":[{"count":1,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5806\/revisions"}],"predecessor-version":[{"id":5807,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/posts\/5806\/revisions\/5807"}],"wp:attachment":[{"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/media?parent=5806"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/categories?post=5806"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bsicos.i3a.es\/es\/wp-json\/wp\/v2\/tags?post=5806"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}