Faculty Member

Call: +34 976 76 2963

Email: epueyo@unizar.es

Address: Mariano Esquillor s/n, 50018, Zaragoza (Spain) (Spain)

ABOUT ME

Esther Pueyo received the M.S. degree in Mathematics from the University of Zaragoza, Spain, in 1999. During 2000, she was a research student at the Department of Mathematics, University of Zaragoza, where she developed a minor thesis in the field of Calculus, supervised by Prof. José Garay. In 2001 she started her Ph.D. studies in Biomedical Engineering at the University of Zaragoza under the supervision of Prof. Pablo Laguna, with a grant supported by the Spanish government. Her Ph.D. studies aimed at developing signal processing techniques applied to the electrocardiogram with the purpose of investigating conditions predisposing to suffer cardiac arrhythmias. During that time, she also worked as an Assistant Professor of Signal Processing at the Department of Electronic Engineering and Communications and she was a visiting scholar at research centers in Portugal, Argentina and UK, with long research visits at St. George’s Hospital Medical School, London, UK, where she worked under the supervision of Prof. Marek Malik.

After finishing her PhD in December 2006, she moved to the University of Oxford, UK (2007-2009) to get postdoctoral training in computational modeling and simulation of cardiac electrophysiology. She worked with Dr. Blanca Rodríguez and Prof. Kevin Burrage in the construction of cell and tissue models to investigate cardiac pathologies and drug-induced effects associated with increased arrhythmic risk. Most of the studies conducted during her postdoctoral period involved collaborations with experts in cardiology and experimental physiology, mainly from Hungary, UK and Sweden.

In January 2011 she was appointed Associate Professor at the University of Zaragoza, Spain. During 2012-2015 she worked as Senior Researcher at the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) after having been awarded with a ‘Ramón y Cajal’ Senior Research fellowship by the Spanish government. At the University of Zaragoza and CIBER-BBN, she works with a group of postdoctoral researchers and PhD, MSc and undergraduate students in the development of methodologies for the analysis of simulated, experimental and clinical data. By combining ECG signal processing and electrophysiological modeling and simulation tools, her current research aims at shedding light on the mechanisms and manifestations of cardiac arrhythmias at scales ranging from cellular ion channels to the electrocardiogram and on the role of important modulators such as the Autonomic Nervous System.

Since October 2015 she is back to her Associate Professor position at the University of Zaragoza. She has participated as Principal Investigator and as Collaborator in different international, European, national and regional research projects. She is currently PI of the ERC Starting Grant project MODELAGE, funded with 1.5 M€, in which a systems biology approach is used to investigate the aging of the human heart.

PUBLICATIONS
300 registros « 6 de 10 »

2019

Conferencias

García, L; Smisdom, N; Mountris, K A; Oliván, A; Vallejo, J M; Fresneda, P C; Fañanás, J; Matamala, M; Sorribas, F; Vázquez, M; Ballester, C; Wolfs, E; Driesen, R B; Ordovás, L; Pueyo, E

Histological characterization of age-related remodeling in human left ventricle by second harmonic generation and lipofuscin content Conferencia

European Society of Cardiology (ESC), vol. Poster, 2019.

BibTeX

García, L; Ramos, E; Oliveros, J C; Torres, R; Pueyo, E; Ordovás, L

Transcriptional analysis of human cardiac aging by chronological and biological age Conferencia

European Society of Cardiology (ESC), 2019.

BibTeX

Hernández-Vicente, A; Hernando, D; Navarrete, D; Vicente, G; Bailón, R; Pueyo, E; Garatachea, N

El nivel de condición física tiene un papel relevante en la dinámica de la repolarización cardíaca Conferencia

II Congreso Internacional en ciéncias de la salud y del deporte, 2019.

Enlaces | BibTeX

Hernández-Vicente, A; Rodríguez-Romo, G; Hernando, D; Vicente-Rodríguez, G; Pueyo, E; Bailón, R; Garatachea, N

La variabilidad de la frecuencia cardíaca como predictor de mortalidad a corto plazo en centenarios Conferencia

61º Congreso de la Sociedad Española de Geriatría y Gerontología / 26º Congreso de la Sociedad Aragonesa de Geriatría y Gerontología, 2019.

Enlaces | BibTeX

2018

Artículos de revista

Bolea, J; Bailón, R; Pueyo, E

On the standardization of approximate entropy: Multidimensional approximate entropy index evaluated on short- term HRV time series Artículo de revista

En: Complexity, vol. Article ID 4953273, pp. 1-15, 2018.

Enlaces | BibTeX

Carro, J; Pueyo, E; Rodríguez, J F

A response surface optimization approach to adjust ionic current conductances of cardiac electrophysiological models. Application to the study of potassium level changes Artículo de revista

En: PLOS ONE, pp. 1-23, 2018.

Enlaces | BibTeX

Grandi, E; Morotti, S; Pueyo, E; Rodriguez, B

Editorial: Safety Pharmacology – Risk Assessment QT Interval Prolongation and Beyond Artículo de revista

En: Frontieres in Physiology, vol. 9, no 678, pp. 1-5, 2018.

Enlaces | BibTeX

Olivan-Viguera, A; Garcia-Otin, A L; Lozano-Gerona, J; Abarca-Lachen, E; Garcia-Malinis, A J; Hamilton, K L; Gilaberte, Y; Pueyo, E; Kohler, R

Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes Artículo de revista

En: PLOS ONE, vol. 13, no 1 e0190307, pp. 1-19, 2018.

Enlaces | BibTeX

Orini, M; Pueyo, E; Laguna, P; Bailón, R

A Time-Varying Nonparametric Methodology for Assessing Changes in QT Variability Unrelated to Heart Rate Variability Artículo de revista

En: IEEE Transactions Biomedical Engineering, vol. 65, no 7, pp. 1443- 1451, 2018.

Enlaces | BibTeX

Conferencias

Ramos-Marqués, E; García-Mendívil, L; Oliveros, J C; Torres-Pérez, R; Oliván, A; Ordovás, L; Pueyo, E

Analysis of the role of microRNA in age-related heart electrophysiological remodeling Conferencia

Aging and Metabolism, Cell Symposia, 2018.

Enlaces | BibTeX

García-Mendívil, L; Ramos-Marqués, E; Oliveros, J C; Torres-Pérez, R; Fernández-Bes, J; Oliván, A; Pueyo, E; Ordovás, L

Transcriptional analysis of human cardiac aging by chronological and biological age Conferencia

Aging and Metabolism, Cell Symposia, 2018.

Enlaces | BibTeX

Ramírez, J; Duijvenboden, S; Laguna, P; Pueyo, E; Tinker, A; Lambiase, P; Munroe, P; Orini, M

Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology Conferencia

Proceedings of the XLV International Conference on Computing in Cardiology, 2018.

Enlaces | BibTeX

Palacios, S; Caiani, E; Martínez, J P; Pueyo, E

Microgravity Exposure Alters Sympathetic Modulation of Ventricular Repolarization Quantified from the ECG via Periodic Repolarization Dynamics Conferencia

Proceedings of the XLV International Conference on Computing in Cardiology, 2018.

Enlaces | BibTeX

Bolea, J; Valenza, G; Bailón, R; Pueyo, E; Barbieri, R

Inhomogeneous Heart Rate Variability Spectral Complexity: A Preliminary Evaluation With Gravitational Stimuli Under Selective Autonomic Blockade Conferencia

Proceedings of the XLV International Conference on Computing in Cardiology, 2018.

Enlaces | BibTeX

Hernández-Vicente, A; Hernando, D; Navarrete-Villanueva, D; López-Laval, I; Vicente-Rodríguez, G; Pueyo, E; Bailón, R; Garatachea, N

La actividad del Sistema Nervioso Autónomo en reposo está relacionada con el nivel de condición física Conferencia

IV Symposio EXERNET Red Española de Investigación en Ejercicio Físico y Salud, Pamplona, Spain, 2018.

Enlaces | BibTeX

Monasterio, V; Pueyo, E; Rodríguez-Matas, J F; Carro, J

Influencia de la corriente de estimulación en las diferencias entre simulaciones electrofisiológicas de célula y tejido Conferencia

XXXVI Congreso Anual de la Sociedad Española de Ingenieríıa Biomédica, Ciudad Real, España, 2018.

Enlaces | BibTeX

Sampedro-Puente, D A; Fernández-Bes, J; Taggart, P; Pueyo, E

Time Course of Cardiac Electrical Oscillatory Behavior in Response to Enhanced Sympathetic Activity and Relation to Arrhytmogenesis Conferencia

10th European Study Group on Cardiovascular Oscillations (ESGCO), Viena, Austria, 2018.

Enlaces | BibTeX

Fernández-Bes, J; Sampedro-Puente, D A; Pueyo, E

A Bayesian Filtering methodology to identify key drivers of ventricular repolarization variability Conferencia

V Conf. Virtual Physiological Human Conference VPH2018, Zaragoza, España, 2018.

Enlaces | BibTeX

Sampedro-Puente, D A; García, L; Ramos, E; Olivan, A; Fernández-Bes, J; Pueyo, E

Cardiac dynamics and arrhythmic risk in aged and failing hearts: insights from experimental and computational research Conferencia

V Conf. Virtual Physiological Human Conference VPH2018, Zaragoza, España, 2018.

Enlaces | BibTeX

Sampedro-Puente, D A; Fernández-Bes, J; Porter, B; Duijvenboden, S; Taggart, P; Pueyo, E

Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability under sympathetic provocation Conferencia

V Conf. Virtual Physiological Human Conference VPH2018, Zaragoza, España, 2018.

Enlaces | BibTeX

Sampedro-Puente, D A; Fernández-Bes, J; Porter, B; Duijvenboden, S; Taggart, P; Pueyo, E

Mechanisms underlying interactions between low-frequency oscillations and beat-to-beat repolarization variability in human ventricles under sympathetic provocation Conferencia

European Working Group on Cardiac Cellular Electrophysiology (EWGCCE), Essen, Alemania, 2018.

BibTeX

2017

Artículos de revista

Sánchez, C; Bueno-Orovio, A; Pueyo, E; Rodríguez, B

Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics Artículo de revista

En: Front Bioeng Biotechnol., vol. 8, pp. 5-29, 2017.

Enlaces | BibTeX

Ramírez, J; Orini, M; Mincholé, A; Monasterio, V; Cygankiewicz, I; Luna, Bayés A; Martínez, J P; Laguna, P; Pueyo, E

Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model Artículo de revista

En: PLOS ONE, vol. 12, no 10: e0186152, pp. 1-15, 2017.

Enlaces | BibTeX

Bolea, J; Lázaro, J; Gil, E; Rovira, E; Remartínez, J M; Laguna, P; Pueyo, E; Navarro, A; Bailón, R

Pulse rate and transit time analysis to predict hypotension events after spinal anesthesia during programmed cesarean labor Artículo de revista

En: Annals Biomedical Enginnering, vol. 45, no 9, pp. 2253–2263, 2017.

Enlaces | BibTeX

Ramírez, J; Orini, M; Mincholé, A; Monasterio, V; Cygankiewicz, I; Luna, Bayés A; Martínez, J P; Pueyo, E; Laguna, P

T-wave Morphology Restitution Predicts Sudden Cardiac Death in Patients with Chronic Heart Failure Artículo de revista

En: Journal of the American Heart Association, no 6: e005310, pp. 1-12, 2017.

Enlaces | BibTeX

Carro, J; Rodríguez-Matas, J F; Monasterio, V; Pueyo, E

Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols Artículo de revista

En: Progress in Biophysics and Molecular Biology, vol. 129, pp. 53-64, 2017.

Enlaces | BibTeX

Ramírez, J; Orini, M; Tucker, J D; Pueyo, E; Laguna, P

Variability of ventricular repolarization dispersion quantified by time-warping the morphology of the T-waves Artículo de revista

En: IEEE Transactions Biomedical Engineering, vol. 64, no 7, pp. 1619-1630, 2017.

Enlaces | BibTeX

Conferencias

Ramírez, J; Orini, M; Pueyo, E; Laguna, P

Quantification of T-wave Morphological Variability Using Time-warping Methods Conferencia

Proceedings of the EMBEC 2017, NBC 2017, 2017.

Enlaces | BibTeX

Carro, J; Rodríguez-Matas, J F; Pueyo, E

Multiscale Methods for Definition of Ionic Variables in Electrophysiological Models Conferencia

Proceedings of the EMBEC 2017, NBC 2017, 2017.

Enlaces | BibTeX

Sampedro-Puente, D A; Fernandez-Bes, J; Pueyo, E

Differential Responses to Beta-Adrenergic Stimulation in the Long-QT Syndrome Type 1: Characterization and Mechanisms Conferencia

Proceedings of the XLIV International Conference on Computing in Cardiology, Rennes, France, 2017.

Enlaces | BibTeX

300 registros « 6 de 10 »