Faculty Member

Call: +34 976 76 2963

Email: epueyo@unizar.es

Address: Mariano Esquillor s/n, 50018, Zaragoza (Spain) (Spain)

ABOUT ME

Esther Pueyo received the M.S. degree in Mathematics from the University of Zaragoza, Spain, in 1999. During 2000, she was a research student at the Department of Mathematics, University of Zaragoza, where she developed a minor thesis in the field of Calculus, supervised by Prof. José Garay. In 2001 she started her Ph.D. studies in Biomedical Engineering at the University of Zaragoza under the supervision of Prof. Pablo Laguna, with a grant supported by the Spanish government. Her Ph.D. studies aimed at developing signal processing techniques applied to the electrocardiogram with the purpose of investigating conditions predisposing to suffer cardiac arrhythmias. During that time, she also worked as an Assistant Professor of Signal Processing at the Department of Electronic Engineering and Communications and she was a visiting scholar at research centers in Portugal, Argentina and UK, with long research visits at St. George’s Hospital Medical School, London, UK, where she worked under the supervision of Prof. Marek Malik.

After finishing her PhD in December 2006, she moved to the University of Oxford, UK (2007-2009) to get postdoctoral training in computational modeling and simulation of cardiac electrophysiology. She worked with Dr. Blanca Rodríguez and Prof. Kevin Burrage in the construction of cell and tissue models to investigate cardiac pathologies and drug-induced effects associated with increased arrhythmic risk. Most of the studies conducted during her postdoctoral period involved collaborations with experts in cardiology and experimental physiology, mainly from Hungary, UK and Sweden.

In January 2011 she was appointed Associate Professor at the University of Zaragoza, Spain. During 2012-2015 she worked as Senior Researcher at the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) after having been awarded with a ‘Ramón y Cajal’ Senior Research fellowship by the Spanish government. At the University of Zaragoza and CIBER-BBN, she works with a group of postdoctoral researchers and PhD, MSc and undergraduate students in the development of methodologies for the analysis of simulated, experimental and clinical data. By combining ECG signal processing and electrophysiological modeling and simulation tools, her current research aims at shedding light on the mechanisms and manifestations of cardiac arrhythmias at scales ranging from cellular ion channels to the electrocardiogram and on the role of important modulators such as the Autonomic Nervous System.

Since October 2015 she is back to her Associate Professor position at the University of Zaragoza. She has participated as Principal Investigator and as Collaborator in different international, European, national and regional research projects. She is currently PI of the ERC Starting Grant project MODELAGE, funded with 1.5 M€, in which a systems biology approach is used to investigate the aging of the human heart.

PUBLICATIONS
343 entries « 1 of 12 »

2025

Journal Articles

Gómez, M; Carro, J; Pueyo, E; Pérez, A; Olivan, A; Monasterio, V

In Silico Modeling and Validation of the Effect of Calcium-Activated Potassium Current on Ventricular Repolarization in Failing Myocytes Journal Article

In: IEEE Journal of Biomedical and Health Informatics, 2025.

Links | BibTeX

Echevarría-Polo, M; Marín, P J; Pueyo, E; Ramos-Maqueda, J; Garatachea, N

Variability and reliability of the Axivity AX6 accelerometer in technical and human motion conditions Journal Article

In: Sensors, vol. 25, iss. 8, no. 2480, 2025.

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Iglesias-García, O; Flandes-Iparraguirre, M; Montero-Calle, P; Rosales, R M; Ullate-Agote, A; Sánchez-Bueno, A; Larequi, E; Anaut-Lusar, I; Laita, N; Oliván-Viguera, A; Iglesias, E; Abizanda, G; Martín-Úriz, P S; Aguirre-Ruiz, P; Aranguren, X L; de Yébenes, M G; Gavira, J J; Martínez, M A; Peña, E; Doblaré, M; de-Juan-Pardo, E M; Pueyo, E; Prosper, F; Vega, M M Mazo

Biologically-inspired melt electrowriting for the generation of highly biomimetic functional myocardium Journal Article

In: Advanced Functional Materials, 2025.

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Sales-Bellés, C; Mincholé, A.; Melero-Polo, J; Cabrera-Ramos, M; Vadillo-Martín, P; Montilla-Padilla, I; Sorinas-Villanueva, L; Julián-García, I; Mayo-Carlos, G V; Ruiz-Arroyo, J R; Pueyo, E; Ramos-Maqueda, J

ECG-based evaluation of ventricular synchrony in left bundle branch area pacing through characterization of the activation sequence Journal Article

In: Scientific Reports, vol. 15, no. 15584, 2025.

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Abdollahpu, M; Celotto, C.; Sánchez, C; Plappert, F; Ostenson, S; Platonov, P G; Laguna, P; Pueyo, E; Sandberg, F

Tilt-induced changes in f-wave characteristics during atrial fibrillation: an experimental and computational investigation Journal Article

In: Frontiers in Physiology Section Autonomic Neuroscience, vol. 16, 2025.

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Bueno-Palomeque, F L; Zacur, E; Pueyo, E; Crispi, F; Laguna, P; Mincholé, A

Electrophysiological Characterization of Preadolescents Born with Intrauterine Growth Restriction: Insights from Clinical and Computational Data Journal Article

In: The Journal of Physiology, 2025.

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Hernández‑Bellido, N; Hernández‑Vicente, A; García‑Mendívil, L; Ramos‑Marquès, E; Hernando, D; Cebollada, A; Köhler, R; Garatachea, N; Pueyo, E; Ordovás, L

A simple blood biomarker based on gene expression describes cardiovascular health‑related biological age Journal Article

In: GeroScience, 2025.

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Perez, C; Martínez, J P; Ramírez, J; Kenttö, T; Junttila, J; Kiviniemi, A; Perkiömäki, J; Huikuri, H; Pueyo, E; Laguna, P

Sudden Cardiac Death Risk Prediction from QT–RR Adaptation Time Lag Computed from Exercise Stress Test ECG Journal Article

In: IEEE Trans. Biomed. Eng., 2025.

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Velarte, A; Sanino, A; Otín, A; Santamaría, B; Artigas, J I; Pueyo, E

Optical fiber integration in PDMS devices for dynamic tissue deformation Journal Article

In: Results in Engineering, vol. 28, no. 107376, 2025.

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Marcos-Pérez, D; Hernández-Vicente, A; Cruces-Salguero, S; Bonvini, M; Vicente-Rodríguez, G; Pueyo, E; Rodríguez-Mañas, L; Abizanda, P; Otaegui, D; Garatachea, N; Matheu, A

Resistance exercise intervention restores functional capacity and improves frailty biomarkers in centenarians Journal Article

In: Sarcopenia and Muscle, vol. 16, no. e70079, 2025.

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Echevarría-Polo, M; Hernandez-Vicente, A; Vadillo-Martín, P; Sanchis-Gomar, F; Melero-Polo, J; Cabrera-Ramos, M; Montilla-Padilla, I; Rucco, A; Martínez, J P; Laguna, P; Pueyo, E; Ramos-Maqueda, J; Garatachea, N

Effects of concurrent training on atrial fibrillation burden, fitness and physical activity after pulmonary vein isolation: Study protocol for a randomized controlled trial Journal Article

In: Current Problems in Cardiology, vol. 51, no. 103218, 2025.

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Conferences

Pérez, A; López, C; García-Mendívil, L; Pueyo, E; Oliván-Viguera, A

Expresión funcional y mecanismos de regulación de los canales SK en pacientes con y sin remodelado cardíaco patológico Conference

Jornadas de Jóvenes Investigadores del I3A, vol. 13, 2025, ISSN: 2341-4790.

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Rucco, A; Martínez, J P; Hernández-Vicente, A; Echevarría, M; Vadillo, P; Garatachea, N; Laguna, P; Ramos, J; Pueyo, E

Impacto de la ablación de FA por crioablación y por campo pulsado en la modulación autonómica cardíaca Conference

Proceedings CASEIB 2025, Zaragoza, 2025.

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Hernández-Alemán, H; Sánchez, C; Mincholé, A; Ramos-Maqueda, J; Melero-Polo, J; Martínez, J P; Pueyo, E

Caracterización de la dinámica espaciotemporal auricular para predecir la recurrencia de la fibrilación auricular tras la ablación Conference

Proceedings CASEIB 2025, Zaragoza, 2025.

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2024

Journal Articles

Celotto, C; Sánchez, C; Abdollahpur, M; Sandberg, F; Rodríguez, J F; Laguna, P; Pueyo, E

The Frequency of Atrial Fibrillatory Waves is Modulated by the Spatiotemporal Pattern of Acetylcholine Release: a 3D Computational Study Journal Article

In: Front. Physiol., vol. 14, no. 1189464, 2024.

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Rosales, R M; Mountris, K A; Oliván-Viguera, A; Pérez-Zabalza, M; Cedillo-Servin, G; Iglesias-García, O; Hrynevich, A; Castilho, M; Malda, J; Prósper, F; Doblaré, M; Mazo, M M; Pueyo, E

Experimentally-guided in silico design of engineered heart tissues to improve cardiac electrical function after myocardial infarction Journal Article

In: Computers in Biology and Medicine, vol. 171, no. 108044, 2024.

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Pérez, C; Pueyo, E; Martínez, J P; Viik, J; Sörnmo, L; Laguna, P

Performance Evaluation of QT-RR Adaptation Time Lag Estimation in Exercise Stress Testing Journal Article

In: IEEE Trans. Biomed. Eng., vol. 71, no. 11, 2024.

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Postigo, A; Hernández-Bellido, N; Sánchez-Barat, M; García-Mendívil, L; Pueyo, E; del Barrio, J; Hernández-Ainsa, S; Ordovás, L

DNA-Based Nanocarriers to Sequester Altered microRNAs in Cardiac Dysfunction Journal Article

In: Adv. Therap., no. 2400247, 2024.

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Bueno, J M; Martínez-Ojeda, R M; Pérez-Zabalza, M; García-Mendívil, L; Asensio, M C; Ordovás, L; Pueyo, E

Analysis of age-related changes in the left ventricular myocardium with multiphoton microscopy Journal Article

In: Biomedical Optics Express, vol. 15, iss. 5, pp. 3251-3264, 2024.

Links | BibTeX

Gómez, M; Carro, J; Pueyo, E; Pérez, A; Oliván-Viguera, A; Monasterio, V

In Silico Modeling and Validation of the Effect of Calcium-Activated Potassium Current on Ventricular Repolarization in Failing Myocytes Journal Article

In: IEEE J Biomed Health Inform, 2024.

Links | BibTeX

Conferences

Pérez, C; Pueyo, E; Martínez, J P; Sörnmo, L; Laguna, P

QT-RR Adaptation Time Lag Estimation and its Dependence on Heart Rate Trend Frequency Content in Exercise Stress Testing Conference

13th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO), 2024.

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Palacios, S; Sales, C; Melero, J; Cabrera, M; Ramos, J; Mincholé, A; Pueyo, E; Martínez, J P

Changes in Ventricular Repolarization After Right Ventricular and Left Bundle Branch Pacing Conference

13th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO), 2024.

Links | BibTeX

Romagnoli, S; Isabel-Roquer, A; Martín-Yebra, A; Palmieri, F; Font, J D Fernandéz; Pueyo, E; Gomis, P; Laguna, P; Arbelo, E; Mincholé, A

Cuantificación sobre el ECG del retraso en la activación ventricular del tracto de salida derecho en pacientes con síndrome de Brugada Conference

Proceedings CASEIB 2024, Sevilla, Spain, 2024.

Links | BibTeX

Bueno-Palomeque, F L; Zacur, E; Pueyo, E; Crispi, F; Laguna, P; Mincholé, A

Implications of IUGR-Related Geometric Heart Changes on the ECG and Electrophysiology: an In silico Perspective Conference

Proceedings of the LI International Conference on Computing in Cardiology, Karlsruhe, Germany, 2024.

Links | BibTeX

Rosales, R M; Doblare, M; Vega, M M Mazo; Pueyo, E

Design of Engineered Heart Tissues to Minimize Arrhythmic Risk After Implantation in Infarcted Hearts Conference

Proceedings of the LI International Conference on Computing in Cardiology, Karlsruhe, Germany, 2024.

Links | BibTeX

Romagnoli, S; Roquero, A I; Martín-Yebra, A; Palmieri, F; Fernandez-Font, J D; Pueyo, E; Gomis, P; Laguna, P; Lainez, E Arbelo; Mincholé, A

Quantification of Delayed Activation in Right Ventricular Outflow Tract in Brugada Patients Conference

Proceedings of the LI International Conference on Computing in Cardiology, Karlsruhe, Germany, 2024.

Links | BibTeX

Velarte, A; Castel, A; Otín, A; Pueyo, E

Compact System for Stimulation and Recording of Field Potentials from Cardiac Tissue Preparations Conference

39th Conference on Design of Circuits and Integrated Systems (DCIS), 2024.

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Noguero-Soler, I; Pueyo, E; Revilla-Martí, P; Ramos-Maqueda, J; Mincholé, A

Análisis de marcadores de riesgo derivados del electrocardiograma en pacientes de cardiomiopatía hipertrófica Conference

Jornadas de Jóvenes Investigadores del I3A, vol. 12, 2024.

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Rodríguez-Carbó, J; Mincholé, A; Pueyo, E

Caracterización basada en ECG de la extensión, gravedad y ubicación espacial de la isquemia aguda Conference

Jornadas de Jóvenes Investigadores del I3A, vol. 12, 2024.

Links | BibTeX

2023

Journal Articles

Garatachea, N; Pueyo, E; Eijsvogels, T

Prevention of sudden death in sports: a global and multidisciplinary observatory for scientific research and knowledge transfer Journal Article

In: Reviews in Cardiovascular Medicine, vol. 24, iss. 1, no. 12, 2023.

Links | BibTeX

343 entries « 1 of 12 »