ECG markers for arrhythmia risk identification

Research line

Diagnosis, monitoring, quantification and risk stratification of cardiac dysfunctions from automatic analysis of multilead ECG, including:

  1. Automatic ECG wave delineation and characterization
  2. the detection and monitoring of cardiac ischemia
  3. Repolarization alternans detection, as an arrhythmic risk indicator
  4. Study of the relationship between repolarization duration (QT interval) and the heart rhythm, together with their dynamic interactions, as an arrhythmic risk indicator.

Investigator in charge

Pablo Laguna Lasaosa

Call: +34 976 76 1931

Email: laguna@unizar.es

Projects

Physical activity for the prediction and prevention of cardiac risk: EXP_75053

Efficacy, safety and mechanisms of new techniques for cardiac stimulation in patients with pacemakers: from computational research to clinical practice – LMP94_21

Digital transformation of clinical practice by using patient-specific cardiac digital twins for risk prediction and therapy optimization (DIGICARDIO) – TED2021-130459B-I00

ECG morphology clusters for sudden cardiac death risk stratification in coronary artery disease using genetics and human-based computational models (STRATEGIC) – PID2021-128972OA-I00

Consulting services for basic physiologic features

Towards improved management of cardiovascular diseases by integrative in silico-in vitro-in vivo research into hearts structure, function and autonomic regulation – PID2019-105674RB-I00

Physiology-driven signal analysis for guiding cardiac arrhythmia management and therapy – PID2019-104881RB-I00

Finished Projects

Scientific Network Observatory for the Study and Prevention of Sudden Death in Sport (PREMUBID)

Biomarkers for Early Detection of Atrial Fibrillation Phase in Strenuous Exercise-Induced Atrial Cardiomyopathy: Prevention of Pafiyama Syndrome

PIC: Personalised in Silico Cardiology

MY-ATRIA: MultidisciplinarY training network for ATrial fibRillation monItoring, treAtment and progression

Detection of K+ concentration alterations from the ECG

Validation of pulse rate variability, respiratory frequency and stress assessment from NIVAband

WECARMON: Wearable Cardiorespiratory Monitor

Multi-Scale Physiology-Driven Computational Tools To Assist In The Assessment And Management Of Cardiac Dysfunctions (MScPhCarDys)

Biomedical Engineering and Medical Physics (BioMep)

Multiscale computational tools to improve diagnosis, risk assessment and treatment in prevalent heart diseases (MULTITOOLS2HEART)

Multimodal analysis and m-Health tools for diagnostic and monitoring improving of Obstructive Lung Disease and Obstructive Sleep Apnea patients (M-LODOSA)

ERC Starting Grant. Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface (MODELAGE)

The Autonomous Nervous System as a modulator of cardiac function: comprehensive investigation through signal processing and computational modeling

Physiology-guided signal processing for cardiac risk stratification and therapy-guided: tools to improve decision-making in cardiac management

Computer-assisted interpretation of electrical signals: a step forward in understanding and treating cardiac diseases (INTERCARDIO)

QT-bed: Evaluation of changes in ventricular repolarization and its relationship with heart rate during bed-rest experiments

Computational investigation of cardiac arrhythmias and drug effect: from ion channels to the surface electrocardiogram

Multimodal biomedical signal processing for the analysis and characterization of cardiovascular, respiratory and autonomic deseases

Technologies and targeting sectors

  • Technology 1

Signal processing software for automatic ECG detection and delineation.

Targeting sector: Biomedical Engineering companies

  • Technology 2

Arrhythmia risk marker extraction form ECG to quantify arrhythmia risk.

Targeting sector: Biomedical Engineering companies

Patents and technology transfer

  • Case 1

Technology transfer agreement with Cradiacmarker company to transfer the repolarization  alternans detection technology.

  • Case 2

Technology transfer agreement with CardioLund Company to develop a web based site for remote ECG signal analysis services.

Singular equipment

Biomedical acquisition lab, including a tilt table set; Finometer for Blood pressure measurement and BIOPAC system for data acquisition.

Social networks

Contact

Phone: +34 876 555 651
Email: bsicos@unizar.es

Address

Campus Río Ebro
C/ Mariano Esquillor, S/N
50018 Zaragoza, Spain
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