Experimental characterization and in-vitro modeling of human cardiac aging for:
- Temporal and spatial variability characterization of the electrophysiology of the human ventricle based on age
- Studying of structural, molecular and autonomic changes in human ventricles induced by aging
- Creating, characterizing and validating an aging in-vitro model based on human iPSC
- Searching for anti-aging targets at molecular level which explain electrophysiological changes linked to age
- Analyzing the effects of aging on congenital cardiomiopathies
Video: BSICoS uses human iPSC-derived myocytes for cardiac research
Investigator in charge
Technologies and targeting sectors
- Technology 1
Cardiac biomarkers as non-invasive tools to predict heart dysfunction in relation to age, heart damage or disease.
Targeting sector: Pharmaceutical and diagnostics companies.
- Technology 2
Discovery of cardiac anti-aging interventions for the development of novel therapies.
Targeting sector: Pharmaceutical companies
Singular equipment and techniques
Human iPSC cell culture lab and genome engineering techniques
Optical Mapping (MiCAM O5-Ultima CMOS camera, SciMedia, Costa Mesa, CA) for electrophysiological recording
Vibratome (VT12000 s, LEICA) for the preparation of myocardial tissue slices
Mechanical electrostimulation system (C-Strecht and C-Pace M, Ion Optix) for organotypic tissue and cell culture