Experimental characterization and in-vitro modeling of cardiac aging

Research line

Experimental characterization and in-vitro modeling of human cardiac
aging for:

  1. Temporal and spatial variability characterization of the electrophysiology of the human ventricle based on age
  2. Studying of structural, molecular and autonomic changes in human ventricles induced by aging
  3. Creating, characterizing and validating an aging in-vitro model based on human iPSC
  4. Searching for anti-aging targets at molecular level which explain electrophysiological changes linked to age
  5. Analyzing the effects of aging on congenital cardiomiopathies

Investigator in charge

Laura Ordovás Vidal

Call: I3A: +34 876 55 51 56; SAI: +34 876 55 43 32

Email: lordovas@unizar.es

Technologies and targeting sectors

  • Technology 1

Cardiac biomarkers as non-invasive tools to
predict heart dysfunction in relation to age, heart damage or disease.
Targeting sector: Pharmaceutical and diagnostics companies.

  • Technology 2

Discovery of cardiac anti-aging interventions
for the development of novel therapies. Targeting sector: Pharmaceutical
companies

Singular equipment and techniques

Human iPSC cell culture lab and genome engineering techniques

Optical Mapping (MiCAM O5-Ultima CMOS camera, SciMedia, Costa
Mesa, CA) for electrophysiological recording

Vibratome (VT12000 s, LEICA) for the preparation of myocardial
tissue slices

Mechanical electrostimulation system (C-Strecht and C-Pace M,
Ion Optix) for organotypic tissue and cell culture

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