Research line

Modeling and simulation of cardiac electrical activity in healthy and diseased hearts, including:

  1. Investigation of atrial arrhythmias: atrial activation and manifestations on electrogram (EGM) and electrocardiogram (ECG) signals
  2. Investigation of ventricular arrhythmias: mechanisms underlying the onset of reentrant arrhythmias and assessment of pro-arrhythmic risk based on ECG biomarkers
  3. Dynamic modeling of myocardial ischemia
  4. Stochastic modeling of ionic current fluctuations in ventricular cells: contribution to temporal and spatial repolarization variability.
cardiac-pulse

Investigator in charge

Technologies and targeting sectors

  • Technology 1

Computational modeling and simulation tools to predict cardio-toxicity of drug compounds. Targeting sector: Pharmaceutical companies

  • Technology 2

Markers for guiding the development of new agents to treat atrial fibrillation. Targeting sector: Pharmaceutical companies

Patents and technology transfer

  • Case 1

Technology transfer agreement with Pfizer pharmaceutical company to improve currently used methods for identification of cardio-toxic drug compounds during the development process.

  • Case 2

Technology transfer agreement with AstraZeneca pharmaceutical company to help in the design and screening of new multi-channel action anti-atrial fibrillation drugs.

Graphic material for the website

3D atrial image from the paper ‘Ionic modulation of atrial fibrillation dynamics in a human 3D atrial model’ by C. Sánchez, M. Krueger, G. Seeman, O. Dössel, B. Rodríguez, E. Pueyo, presented at the Computing in Cardiology conference, 2012.

Singular equipment

Not available

Projects

Finished Projects