Modeling and simulation of cardiac electrophysiology

Research line

Modeling and simulation of cardiac electrical activity in healthy and diseased hearts, including:

  1. Investigation of atrial arrhythmias: atrial activation and manifestations on electrogram (EGM) and electrocardiogram (ECG) signals
  2. Investigation of ventricular arrhythmias: mechanisms underlying the onset of reentrant arrhythmias and assessment of pro-arrhythmic risk based on ECG biomarkers
  3. Dynamic modeling of myocardial ischemia
  4. Stochastic modeling of ionic current fluctuations in ventricular cells: contribution to temporal and spatial repolarization variability.

Investigator in charge

Esther Pueyo Paules

Call: +34 976 76 2963



Technologies and targeting sectors

  • Technology 1

Computational modeling and simulation tools to predict cardio-toxicity of drug compounds. Targeting sector: Pharmaceutical companies

  • Technology 2

Markers for guiding the development of new agents to treat atrial fibrillation. Targeting sector: Pharmaceutical companies

Patents and technology transfer

  • Case 1

Technology transfer agreement with Pfizer pharmaceutical company to improve currently used methods for identification of cardio-toxic drug compounds during the development process.

  • Case 2

Technology transfer agreement with AstraZeneca pharmaceutical company to help in the design and screening of new multi-channel action anti-atrial fibrillation drugs.

Singular equipment

Not available

Graphic material for the website

3D atrial image from the paper ‘Ionic modulation of atrial fibrillation dynamics in a human 3D atrial model’ by C. Sánchez, M. Krueger, G. Seeman, O. Dössel, B. Rodríguez, E. Pueyo, presented at the Computing in Cardiology conference, 2012.

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