Non-invasive parametrization of autonomic nervous system

Research line

Non-invasive parametrization of autonomic nervous system activity through the analysis of the dynamics and interactions of signals derived from electrocardiogram (ECG), blood pressure (BP), and pulse photoplethysmography signals (PPG), such as heart rate variability (HRV), BP variability and pulse transit time (PTT). Applications:

  1. Analysis and modeling of HRV during exercise.
  2. Detection of drowsiness in drivers.
  3. Identification of stress, emotional states and effects of music.
  4. Discrimination of patients resistant or prone to suffer hypotension during hemodialysis.
  5. Prediction of hypotension during spinal anesthesia in cesarean delivery.

Investigator in charge

Raquel Bailón Luesma

Call: +34 976762876

Email: rbailon@unizar.es

Finished Projects

Scientific Network Observatory for the Study and Prevention of Sudden Death in Sport (PREMUBID)

PPG-based sleep apnea monitoring

Research Network in Epidemiology and Prevention of Cardiovascular Risk in Sports

Towards an early identification of depression through a process of physiological signals and metabolomic biomarkers

Improved monitoring of the autonomic nervous system during daily life applied to stress, depression and exercise

Biomedical monitoring prototype integrated in diving equipment for underwater environment

Improvement of a device for real-time monitoring of the photoplestimographic signal in hyperbaric environments

Autonomic nervous system surrogates, cardiopulmonary coupling and respiratory parameters as predictors of successful weaning in mechanically ventilated patients

Detection of K+ concentration alterations from the ECG

Validation of pulse rate variability, respiratory frequency and stress assessment from NIVAband

WECARMON: Wearable Cardiorespiratory Monitor

Optimization of a submersible device for monitoring the photoplesthymographic signal

Biomedical Engineering and Medical Physics (BioMep)

Remote Assessment of Disease and Relapse in Central Nervous System Disorders (RADAR-CNS)

Patterns of Autonomic Nervous System Biomarkers in Depression (DEANS)

Multimodal analysis and m-Health tools for diagnostic and monitoring improving of Obstructive Lung Disease and Obstructive Sleep Apnea patients (M-LODOSA)

Effects of an early neurocognitive intervention on patient-ventilator interaction and stress in critically ill patients receiving mechanical ventilation (PVI-ANS-NCOG)

Design and validation of a submersible device for the monitoring of the Autonomous Nervous System through the recording of pulse photoplethysmography in aquatic activities

Identification of situations of decreased performance of the military, based on the relationship of heart rate variability with stress and sleep deprivation

Study of the behavior of the autonomic nervous system and cognitive abilities in hyperbaric environments

Noninvasive assessment of autonomic nervous system through the analysis of biosignals variability. Application to stress-related clinical problem

Decision support systems in pathological or physiological stress by assessing the state of the autonomic nervous system through signal processing

The Autonomous Nervous System as a modulator of cardiac function: comprehensive investigation through signal processing and computational modeling

Computer-assisted interpretation of electrical signals: a step forward in understanding and treating cardiac diseases (INTERCARDIO)

QT-bed: Evaluation of changes in ventricular repolarization and its relationship with heart rate during bed-rest experiments

Computational investigation of cardiac arrhythmias and drug effect: from ion channels to the surface electrocardiogram

Multimodal biomedical signal processing for the analysis and characterization of cardiovascular, respiratory and autonomic deseases

Technologies and targeting sectors

  • Technology 1

Robust estimation of cardiovascular variability signals (HRV, BPV, PTT)

Targeting sector: Biomedical Engineering companies, Companies developing monitoring equipment in sports and psychology fields.

  • Technology 2

Analysis and interpretation of the dynamics and interactions of cardiovascular variability signals

Targeting sector: Biomedical Engineering companies, Companies developing monitoring equipment in sports and psychology fields.

Patents and technology transfer

  • Case 1

Technology transfer agreement with the company Ficomirrors S.A. of the detector of drivers’ saturation and relaxation level.

  • Case 2

Technology transfer agreement with the Universitary Hospital Miguel Servet for the development of the predictor of hypotension during spinal anesthesia during cesarean delivery.

Singular equipment

Biomedical acquisition lab, including a tilt table set; Finometer for Blood pressure measurement and BIOPAC system for data acquisition.

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