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Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution

Aging is the main risk factor for cardiovascular diseases. In humans, cardiac aging remains poorly characterized. Most studies are based on chronological age (CA) and disregard biological age (BA), the actual physiological age (result of the aging rate on the organ structure and function), thus yielding potentially imperfect outcomes. Deciphering the molecular basis of ventricular aging, especially by BA, could lead to major progresses in cardiac research. We aim to describe the transcriptome dynamics of the aging left ventricle (LV)…

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Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution
A wearable armband gets to the heart of the matter

A wearable armband gets to the heart of the matter

Electrocardiogram (ECG) monitoring is traditionally used to screen patients who suffer from or are likely to develop cardiovascular disease. WECARMON has come up with a comfortable armband for non-invasively monitoring cardiac and respiratory parameters long-term. Patients suffering from chronic inflammatory lung conditions such as chronic obstructive pulmonary disease (COPD) have a higher risk of developing heart problems due to obstructed airflow from the lungs. In addition, the condition obstructive sleep apnoea syndrome (OSAS), which is associated with abnormal breathing during…

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Photoplethysmographic Waveform and Pulse Rate Variability Analysis in Hyperbaric Environments

Morphological changes in pulse rate could provide complementary information to that extracted from the pulse rate variability on the response of the cardiovascular and nervous systems of subjects exposed to hyperbaric environments. The peripheral activation produces a vasoconstriction that increases the pulse width and area. However, the pulse width of the anacrotic phase seems to be a better marker in the variation of peripheral vascular resistance than the pulse width. Pelaez-Coca, M D; Hernando, A; Lozano, M T; Sanchez, C;…

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Photoplethysmographic Waveform and Pulse Rate Variability Analysis in Hyperbaric Environments
At the NeoCom 2021 Conference, talking about biomedical signal processing

At the NeoCom 2021 Conference, talking about biomedical signal processing

Jesús Lázaro, researcher of the BSiCoS group of the I3A, at the University of Zaragoza, participated in the Neocom Conference, held this March and organized by the Association of Telecommunications Students of the University of Zaragoza. He spoke about his research work around biomedical signal processing, how it can be used to improve the current understanding of the functioning of biological systems, conditions related to the cardiovascular, respiratory, and autonomic nervous systems, as well as their interactions. In addition, he…

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Characterization of T Wave Amplitude, Duration and Morphology Changes during Hemodialysis: Relationship with Serum Electrolyte Levels and Heart Rate

Chronic kidney disease affects more than 10% of the world population. Changes in serum ion concentrations increase the risk for ventricular arrhythmias and sudden cardiac death, particularly in end stage renal disease (ESRD) patients. We characterized how T wave amplitude, duration and morphology descriptors change with variations in serum levels of potassium and calcium and in heart rate, both in ESRD patients and in simulated ventricular fibers. Electrocardiogram (ECG) recordings from twenty ESRD patients undergoing hemodialysis (HD) and pseudo-ECGs (pECGs)…

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Characterization of T Wave Amplitude, Duration and Morphology Changes during Hemodialysis: Relationship with Serum Electrolyte Levels and Heart Rate
Monitoring Blood Potassium Concentration in Hemodialysis Patients by Quantifying T-wave Morphology Dynamics

Monitoring Blood Potassium Concentration in Hemodialysis Patients by Quantifying T-wave Morphology Dynamics

We investigated the ability of time-warping-based ECG-derived markers of T-wave morphology changes in time (dw) and amplitude (da), as well as their non-linear components (dNLw and dNLa), and the heart rate corrected counterpart (dw,c), to monitor potassium concentration ([K+]) changes (Δ[K+]) in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). We compared the performance of the proposed time-warping markers, together with other previously proposed [K+] markers, such as T-wave width (Tw) and T-wave slope-to-amplitude ratio (TS/A), when computed from standard…

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Electrocardiogram-Derived Tidal Volume During Treadmill Stress Test

Electrocardiogram (ECG) has been regarded as a source of respiratory information with the main focus in the estimation of the respiratory rate. Although little research concerning the estimation of tidal volume (TV) has been conducted, there are several ECG-derived features that have been related with TV in the literature, such as ECG-derived respiration, heart rate variability or respiratory rate. In this work, we exploited these features for estimating TV using a linear model. 25 young (33.4 ± 5.2 years) healthy male volunteers were recruited for performing…

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Electrocardiogram-Derived Tidal Volume During Treadmill Stress Test
Three of our young researchers participate in the First Conference of the I3A

Three of our young researchers participate in the First Conference of the I3A

The BSiCoS group will be at the I3A Conference, where we will participate in the Young Researchers Meeting: - Pablo Armañac: The capacity of the baroreflex as an identification index of ICU patients prepared for weaning - Cristina Pérez: From the stress test to the prediction of sudden cardiac death using non-invasive markers - Saúl Palacios: Periodic dynamics of repolarization as a predictor of sudden death in patients with chronic heart failure Date: Friday, December 11 Time: 9 am -…

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We will present five works at the XXXVII Annual Congress of the Spanish Society of Biomedical Engineering

This year, we will virtually attend the XXXVII Annual Congress of the Spanish Society of Biomedical Engineering (CASEIB) between November 25 and 27. Five of our researchers will defend the work carried out in our research group. CASEIB is a national reference forum for exchanging knowledge and experiences and promoting R + D + i in Biomedical Engineering. This is the BSiCoS group participation program: November 25 “Delay between QT and RR in stress test records as an indicator of…

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We will present five works at the XXXVII Annual Congress of the Spanish Society of Biomedical Engineering
BSiCoS researchers apply engineering and mathematics to see the real activity of a person’s heart

BSiCoS researchers apply engineering and mathematics to see the real activity of a person’s heart

Researchers from the BSiCoS group, at the Engineering Research Institute of Aragon (I3A), University of Zaragoza, work from Engineering and Mathematics to know the functioning of the heart, see how its activity is when it is healthy and how it changes when a heart attack occurs, provide clinical specialists with the tools that they need to improve patient care. They do it through computation in cardiology, with the creation of a virtual heart that allows the computer to reproduce the…

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BSICOS, at the XIV CIBER-BBN Annual Conference

Next Monday and Tuesday, November 16 and 17, we will attend the XIV CIBER-BBN Annual Conference. Our research group will be represented by Pablo Armañac and Alejando Alcaine, who will present their research work at this meeting that, this year, will be online.   Pablo Armañac will participate with his work "Autonomic nervous system surrogates, cardiopulmonary coupling and respiratory parameters as predictors of successful weaning in mechanically ventilated patients (ANS-RESP-WEANING)", on Monday at 12:45.   Alejandro Alcaine, will speak on…

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BSICOS, at the XIV CIBER-BBN Annual Conference
Automatic quantification of cardiomyocyte dimensions and connexin 43 lateralization in fluorescence images

Automatic quantification of cardiomyocyte dimensions and connexin 43 lateralization in fluorescence images

Cardiomyocytes’ geometry and connexin 43 (CX43) amount and distribution are structural features that play a pivotal role in electrical conduction. Their quantitative assessment is of high interest in the study of arrhythmias, but it is usually hampered by the lack of automatic tools. In this work, we propose a software algorithm (Myocyte Automatic Retrieval and Tissue Analyzer, MARTA) to automatically detect myocytes from fluorescent microscopy images of cardiac tissue, measure their morphological features and evaluate the expression of CX43 and its degree of lateralization. The proposed software is based on the generation…

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We are looking for a PhD candidate

PhD contract and topic A PhD contract (former FPI program) is offered for a PhD position at the Biomedical Signal Interpretation and Computational Simulation (BSICoS) group of the Aragón Institute of Engineering Research, University of Zaragoza. The PhD thesis is associated with the research grant “Towards improved management of cardiovascular diseases by integrative in silico-in vitro-in vivo research into heart’s structure, function and autonomic regulation”, funded by Spanish Ministry of Science and Innovation, with reference PID2019-105674RB-I00. As part of his/her…

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We are looking for a PhD candidate
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