Faculty Member

Call: +34 976 76 2963

Email: epueyo@unizar.es

Address: Mariano Esquillor s/n, 50018, Zaragoza (Spain) (Spain)

ABOUT ME

Esther Pueyo received the M.S. degree in Mathematics from the University of Zaragoza, Spain, in 1999. During 2000, she was a research student at the Department of Mathematics, University of Zaragoza, where she developed a minor thesis in the field of Calculus, supervised by Prof. José Garay. In 2001 she started her Ph.D. studies in Biomedical Engineering at the University of Zaragoza under the supervision of Prof. Pablo Laguna, with a grant supported by the Spanish government. Her Ph.D. studies aimed at developing signal processing techniques applied to the electrocardiogram with the purpose of investigating conditions predisposing to suffer cardiac arrhythmias. During that time, she also worked as an Assistant Professor of Signal Processing at the Department of Electronic Engineering and Communications and she was a visiting scholar at research centers in Portugal, Argentina and UK, with long research visits at St. George’s Hospital Medical School, London, UK, where she worked under the supervision of Prof. Marek Malik.

After finishing her PhD in December 2006, she moved to the University of Oxford, UK (2007-2009) to get postdoctoral training in computational modeling and simulation of cardiac electrophysiology. She worked with Dr. Blanca Rodríguez and Prof. Kevin Burrage in the construction of cell and tissue models to investigate cardiac pathologies and drug-induced effects associated with increased arrhythmic risk. Most of the studies conducted during her postdoctoral period involved collaborations with experts in cardiology and experimental physiology, mainly from Hungary, UK and Sweden.

In January 2011 she was appointed Associate Professor at the University of Zaragoza, Spain. During 2012-2015 she worked as Senior Researcher at the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) after having been awarded with a ‘Ramón y Cajal’ Senior Research fellowship by the Spanish government. At the University of Zaragoza and CIBER-BBN, she works with a group of postdoctoral researchers and PhD, MSc and undergraduate students in the development of methodologies for the analysis of simulated, experimental and clinical data. By combining ECG signal processing and electrophysiological modeling and simulation tools, her current research aims at shedding light on the mechanisms and manifestations of cardiac arrhythmias at scales ranging from cellular ion channels to the electrocardiogram and on the role of important modulators such as the Autonomic Nervous System.

Since October 2015 she is back to her Associate Professor position at the University of Zaragoza. She has participated as Principal Investigator and as Collaborator in different international, European, national and regional research projects. She is currently PI of the ERC Starting Grant project MODELAGE, funded with 1.5 M€, in which a systems biology approach is used to investigate the aging of the human heart.

PUBLICATIONS
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2023

Conferences

Noguero-Soler, I; Revilla, P; Ramos, J; Pueyo, E; Mincholé, A

ECG Morphology-Based Markers for Risk Stratification in Hypertrophic Cardiomyopathy Conference

Proceedings of the XLIX International Conference on Computing in Cardiology, Atlanta, USA, 2023.

Links | BibTeX

Rodríguez-Carbó, J; Mincholé, A; Pueyo, E

ECG-based Characterization of the Extent, Severity and Spatial Location of Acute Ischemia in Patients with and without Prior Myocardial Infarction Conference

Proceedings of the XLIX International Conference on Computing in Cardiology, Atlanta, USA, 2023.

Links | BibTeX

Pérez, C; Pueyo, E; Martínez, J P; Sörnmo, L; Laguna, P

Evaluation of a QT Adaptation Time Estimator for ECG Exercise Stress Test in Controlled Simulation Conference

Proceedings of the XLIX International Conference on Computing in Cardiology, Atlanta, USA, 2023.

Links | BibTeX

Rosales, R; Mountris, K; Doblaré, M; Mazo, M; Pueyo, E

In Silico Assessment of Arrhythmic Risk in Infarcted Ventricles Engrafted with Engineered Heart Tissues Conference

Proceedings of the XLIX International Conference on Computing in Cardiology, Atlanta, USA, 2023.

Links | BibTeX

Sales-Bellés, C; Mincholé, A; Melero, J; Cabrera-Ramos, M; Montilla-Padilla, I; Sorinas, L; Julián, I; Pueyo, E; Ramos, J

Left Bundle Branch Area Pacing Generates More Physiological Ventricular Activation Sequences than Right Ventricular Pacing Conference

Proceedings of the XLIX International Conference on Computing in Cardiology, Atlanta, USA, 2023.

Links | BibTeX

García-Mendívil, L; Pérez, M; Rosales, R; Vallejo-Gil, J M; Fañanás-Mastral, J; Vázquez-Sancho, M; Bellido‑Morales, J A; Vaca‑Núñez, A S; Ballester-Cuenca, C; Ordovás, L; Pueyo, E

Physiological Variations in CX43 and Fibrosis Deposition Affect Human Ventricular Electrophysiology Promoting Arrhythmia Conference

Proceedings of the XLIX International Conference on Computing in Cardiology, Atlanta, USA, 2023.

Links | BibTeX

Bueno-Palomeque, F L; Mountris, K; Ortigosa, N; Bailón, R; Bijnens, B; Crispi, F; Pueyo, E; Mincholé, A; Laguna, P

QRS Width and T-peak to T-end Interval Are Prolonged in Preadolescents with Severe Intrauterine Growth Restriction at Birth When Compared to Controls Conference

Proceedings of the XLIX International Conference on Computing in Cardiology, Atlanta, USA, 2023.

Links | BibTeX

Palacios, S; Smisek, R; Curila, K; Nguyen, U C; Prinzen, F; Halamek, J; Plesinger, F; Jurak, P; Pueyo, E; Martínez, J P

Spatial Dispersion of Activation and Repolarization Times Associated with Different Cardiac Pacing Modes Conference

Proceedings of the XLIX International Conference on Computing in Cardiology, Atlanta, USA, 2023.

Links | BibTeX

Bueno, J M; Martínez-Ojeda, R M; Asensio, M C; García-Mendívil, L; Pérez-Zabalza, M; Ordovás, L; Pueyo, E

Age-related Changes in Tissue Structure of the Heart Left Ventricle Assessed with Multiphoton Microscopy Conference

Optica Biophotonics Congress: Optics in the Life Sciences, Vancouver (Canada), 2023.

BibTeX

Hernández-Bellido, N; Ramos-Marquès, E; Hernández-Vicente, A; García-Mendívil, L; Santanter-Badules, H; Mercanti, G; Garrido-Huéscar, E; Garatachea, N; Kohler, R; Pueyo, E; Ordovás, L

microRNAs in human cardiac aging: therapeutic targets and biomarkers Conference

I Congreso de Estudiantes de Doctorado Iberus Connect (CEDIC), Zaragoza (Spain), 2023.

BibTeX

Garrido-Huéscar, E; Vandeweyer, L; García-Mendívil, L; Hernández-Bellido, N; Pueyo, E; Vos, W H De; Ordovás, L

A progerin-inducible human Induced Pluripotent Stem Cell line to study cardiac cell aging Conference

4th International Meeting on Laminopathies, Madrid (Spain), 2023.

BibTeX

González-Lana, S; Oliván-Viguera, A; Rosales, R M; Remacha, A R; Ordovás, L; Pueyo, E; Monge, R; Sánchez-Somolinos, C; Ciriza, J; Ochoa, I

Structural and functional impact of co-culturing iPSC-CM and HCAEC within microfluidic devices exposed to mechanical and electrical stimuli Conference

European organ-on-chip society Annual Meeting, Berlin (Alemania), 2023.

BibTeX

Hernández-Bellido, N; Postigo, A; Orrite, C; Garrido-Huéscar, E; García-Mendívil, L; Pueyo, E; Hernández-Ainsa, S; Ordovás, L

Non-viral delivery of microRNA therapies for cardiac dysfunction using DNA nanostructures Conference

12º Congreso bianual de la Sociedad Española de Terapia Génica y Celular (SETGyC), Pamplona (Sapin), 2023.

BibTeX

Garrido-Huéscar, E; Verschuuren, M; Vandeweyer, L; Santander-Badules, H; Pueyo, E; Vos, W H De; Ordovás, L

High-content phenotypic profiling to advance the maturation state of human induced pluripotent stem cells derived cardiomyocytes Conference

Cellular Biology of the Heart & Myocardial Function (CBFH) Biennial meeting 2023, Naples (Italy), 2023.

BibTeX

Postigo, A; Hernández-Bellido, N; Sánchez-Barat, M; Orrite, C; Garrido-Huéscar, E; García-Mendívil, L; Pueyo, E; Ordovás, L; Hernández-Ainsa, S

Design of DNA-based nanocarriers for the delivery of microRNA therapies against cardiac dysfunction Conference

Cellular Biology of the Heart & Myocardial Function (CBFH) Biennial meeting 2023, Naples (Italy), 2023.

BibTeX

García-Mendívil, L; Hernández-Bellido, N; Sánchez-Barat, M; Pérez-Zabalza, M; Garrido-Huéscar, E; Vallejo-Gil, J M; Matamala-Adell, M; Sorribas-Berjón, J F; Bellido‑Morales, J A; Vaca‑Núñez, A S; Ballester-Cuenca, C; Verfaillie, C M; Pueyo, E; Ordovás, L

Progerin is an unlikely contributor to natural cardiac aging, but promotes age-related phenotypes in vitro Conference

Cellular Biology of the Heart & Myocardial Function (CBFH) Biennial meeting 2023, Naples (Italy), 2023.

BibTeX

Hernández-Bellido, N; Ramos-Marquès, E; Hernández-Vicente, A; García-Mendívil, L; Santander-Badules, H; Garrido-Huéscar, E; Sánchez-Barat, M; Garatachea, N; Kohler, R; Pueyo, E; Ordovás, L

Identification of biological age indicators as potential predictors of physical and cardiac-related conditions Conference

Cellular Biology of the Heart & Myocardial Function (CBFH) Biennial meeting 2023, Naples (Italy), 2023.

BibTeX

Javierre, M; Kloostermann, M; Dam, P Van; Eijsvogels, T; Pueyo, E; Bailón, R

Análisis de la variabilidad de la frecuencia cardíaca en maratonianos Conference

VLI Congreso de la Sociedad Española de Ingeniería Biomédica CASEIB, Cartagena, España, 2023.

Links | BibTeX

Palacios, S; Smisek, R; Curila, K; Nguyen, U; Prinzen, F W; Halamek, J; Plesinger, F; Jurak, P; Martínez, J P; Pueyo, E

Dispersión espacial de los tiempos de activación y repolarización asociada a diferentes modos de estimulación cardiaca Conference

VLI Congreso de la Sociedad Española de Ingeniería Biomédica CASEIB, Cartagena, España, 2023.

Links | BibTeX

Pérez, C; Pueyo, E; Martínez, J P; Sörnmo, L; Laguna, P

Estimadores del retardo entre las series de QT y RR en registros ECG de prueba de esfuerzo: evaluación en simulación Conference

VLI Congreso de la Sociedad Española de Ingeniería Biomédica CASEIB, Cartagena, España, 2023.

Links | BibTeX

2022

Journal Articles

García-Mendívil, L; Pérez-Zabalza, M; Mountris, K; Duwé, S; Smisdom, N; Pérez, M; Luján, L; Wolfs, E; Driesen, R B; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Vázquez-Sancho, M; Matamala-Adell, M; Sorribas-Berjón, J F; Bellido-Morales, J A; Mancebón-Sierra, F J; Vaca-Núñez, A S; Ballester-Cuenca, C; Oliván-Viguera, A; Diez, E; Ordovás, L; Pueyo, E

Analysis of age-related left ventricular collagen remodeling in living donors: implications in arrhythmogenesis Journal Article

In: iScience, 2022.

Links | BibTeX

Sánchez, F J; Pueyo, E; Diez, E R

Strain echocardiography to predict postoperative atrial fibrillation Journal Article

In: Int. J. Mol. Sci., vol. 23, pp. 1355, 2022.

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Bukhari, H A; Sánchez, C; Srinivasan, S; Palmieri, F; Potse, M; Laguna, P; Pueyo, E

Estimation of Potassium Levels in Hemodialysis Patients by T wave Nonlinear Dynamics and Morphology Markers Journal Article

In: Computers in Biology and Medicine, In press, 2022.

Links | BibTeX

Palmieri, F; Gomis, P; Ferreira, D; Pueyo, E; Martínez, J P; Laguna, P; Ramírez, J

Weighted Time Warping Improves T-wave Morphology Markers Clinical Significance Journal Article

In: IEEE Trans Biomed Eng, 2022.

Links | BibTeX

Bukhari, H A; Sánchez, C; Ruiz, J E; Potse, M; Laguna, P; Pueyo, E

Monitoring of Serum Potassium and Calcium Levels in End-stage Renal Disease Patients by ECG Depolarization Morphology Analysis Journal Article

In: Sensors, vol. 22, no. 2951, 2022.

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Albors, C; Lluch, E; Gomez, J F; Cedilnik, N; Mountris, K A; Mansi, T; Khamzin, S; Dokuchaev, A; Solovyova, O; Pueyo, E; Sermesant, M; Sebastian, R; Morales, H G; Camara, O

Meshless electrophysiological modeling of cardiac resynchronization therapy—benchmark analysis with finite-element methods in experimental data Journal Article

In: Applied Sciences, vol. 12, no. 6438, 2022.

Links | BibTeX

Barrio, R; Martínez, M A; Serrano, S; Pueyo, E

Dynamical mechanism for generation of arrhythmogenic early afterdepolarizations in cardiac myocytes: Insights from in silico electrophysiological models Journal Article

In: Physical Review E., vol. 106, no. 024402, 2022.

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Montero-Calle, P; Flandes-Iparraguirre, M; Mountris, K; Nava, A S; Laita, N; Rosales, R M; Iglesias-García, O; De-Juan-Pardo, E M; Atienza, F; Fernández-Santos, M E; Peña, E; Doblaré, M; Gavira, J J; Fernández-Avilés, F; Prosper, F; Pueyo, E; Vega, M M Mazo

Fabrication of human myocardium using multidimensional modelling of engineered tissues Journal Article

In: Biofabrication, 2022.

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Monasterio, V; Pueyo, E; Rodríguez-Matas, J F; Carro, J

Cardiac cells stimulated with an axial current-like waveform reproduce electrophysiological properties of tissue fibers Journal Article

In: Computer Methods and Programs in Biomedicine, 2022.

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Hernández-Vicente, A; Marín-Puyalto, J; Pueyo, E; Vicente-Rodríguez, G; Garatachea, N

Physical activity in centenarians beyond cut-point-based accelerometer metrics Journal Article

In: International Journal of Environmental Research and Public Health, 2022.

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324 entries « 2 of 11 »