Faculty Member

Call: +34 976 76 2963

Email: epueyo@unizar.es

Address: Mariano Esquillor s/n, 50018, Zaragoza (Spain) (Spain)

ABOUT ME

Esther Pueyo received the M.S. degree in Mathematics from the University of Zaragoza, Spain, in 1999. During 2000, she was a research student at the Department of Mathematics, University of Zaragoza, where she developed a minor thesis in the field of Calculus, supervised by Prof. José Garay. In 2001 she started her Ph.D. studies in Biomedical Engineering at the University of Zaragoza under the supervision of Prof. Pablo Laguna, with a grant supported by the Spanish government. Her Ph.D. studies aimed at developing signal processing techniques applied to the electrocardiogram with the purpose of investigating conditions predisposing to suffer cardiac arrhythmias. During that time, she also worked as an Assistant Professor of Signal Processing at the Department of Electronic Engineering and Communications and she was a visiting scholar at research centers in Portugal, Argentina and UK, with long research visits at St. George’s Hospital Medical School, London, UK, where she worked under the supervision of Prof. Marek Malik.

After finishing her PhD in December 2006, she moved to the University of Oxford, UK (2007-2009) to get postdoctoral training in computational modeling and simulation of cardiac electrophysiology. She worked with Dr. Blanca Rodríguez and Prof. Kevin Burrage in the construction of cell and tissue models to investigate cardiac pathologies and drug-induced effects associated with increased arrhythmic risk. Most of the studies conducted during her postdoctoral period involved collaborations with experts in cardiology and experimental physiology, mainly from Hungary, UK and Sweden.

In January 2011 she was appointed Associate Professor at the University of Zaragoza, Spain. During 2012-2015 she worked as Senior Researcher at the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) after having been awarded with a ‘Ramón y Cajal’ Senior Research fellowship by the Spanish government. At the University of Zaragoza and CIBER-BBN, she works with a group of postdoctoral researchers and PhD, MSc and undergraduate students in the development of methodologies for the analysis of simulated, experimental and clinical data. By combining ECG signal processing and electrophysiological modeling and simulation tools, her current research aims at shedding light on the mechanisms and manifestations of cardiac arrhythmias at scales ranging from cellular ion channels to the electrocardiogram and on the role of important modulators such as the Autonomic Nervous System.

Since October 2015 she is back to her Associate Professor position at the University of Zaragoza. She has participated as Principal Investigator and as Collaborator in different international, European, national and regional research projects. She is currently PI of the ERC Starting Grant project MODELAGE, funded with 1.5 M€, in which a systems biology approach is used to investigate the aging of the human heart.

PUBLICATIONS
300 registros « 7 de 10 »

2017

Conferencias

Fernandez-Bes, J; Sampedro-Puente, D A; Pueyo, E

Identification of Parameters describing Phenomenological Cardiac Action Potential Models using Sigma-Point Methods Conferencia

Proceedings of the XLIV International Conference on Computing in Cardiology, Rennes, France, 2017.

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Ramírez, J; Orini, M; Pueyo, E; Laguna, P

Comparison of ECG T-wave Duration and Morphology Restitution Markers for Sudden Cardiac Death Prediction in Chronic Heart Failure Conferencia

Proceedings of the XLIV International Conference on Computing in Cardiology, Rennes, France, 2017.

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Ramírez, J; Orini, M; Pueyo, E; Laguna, P

T-wave Morphology Restitution Dependency with Heart Rate Range and Its Association with Sudden Cardiac Death in Chronic Heart Failure Conferencia

Proceedings of the XLIV International Conference on Computing in Cardiology, Rennes, France, 2017.

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2016

Artículos de revista

Bolea, J; Pueyo, E; Orini, M; Bailón, R

Influence of heart rate in nonlinear HRV indices as a sampling rate effect evaluated on supine and standing Artículo de revista

En: Front. Physiol, vol. 7, no 501, pp. 1-12, 2016.

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Vicente, J; Johannesen, L; Hosseini, M; Mason, J W; Sager, P T; Pueyo, E; Strauss, D G

Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block Artículo de revista

En: PLOS ONE, pp. 1-16, 2016.

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Pueyo, E; Dangerfield, C E; Britton, O J; Virág, L; Kistamás, K; Szentandrássy, N; Jost, N; Varró, A; Nánási, P P; Burrage, K; Rodríguez, B

Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition Artículo de revista

En: PLOS ONE, pp. 1-20, 2016.

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Pueyo, E; Orini, M; Rodríguez, J F; Taggart, P

Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans Artículo de revista

En: Journal of Molecular and Cellular Cardiology, vol. 97, pp. 93-105, 2016.

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Romero, D; Martínez, J P; Laguna, P; Pueyo, E

Ischemia detection from morphological QRS angles changes Artículo de revista

En: Physiological Measurement, vol. 37, pp. 1004-1023, 2016.

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Laguna, P; Martínez, J P; Pueyo, E

Techniques for ventricular repolarization instability assessment from the ECG Artículo de revista

En: Proceedings of the IEEE, vol. 104, no 2, pp. 392-415, 2016.

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Conferencias

Ramírez, J; Orini, M; Tucker, J D; Pueyo, E; Laguna, P

An Index for T-wave Pointwise Amplitude Variability Quantification Conferencia

Proceedings of the XLIII International Conference on Computing in Cardiology, Vancouver, BC, Canada, 2016.

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Ramírez, J; Orini, M; Tucker, J D; Pueyo, E; Laguna, P

Cuantificación de la Variabilidad de la Amplitud de la Onda T Mediante Técnicas de Re-parametrización Temporal Conferencia

Proceedings XXXIV Congreso Anual de la Sociedad Española de Ingeniería Biomédica, 2016, ISBN: 978-84-9048-531-6.

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2015

Artículos de revista

Vicente, J; Johannesen, L; Mason, J W; Pueyo, E; Stockbridge, N; Strauss, D G

Sex Differences in Drug-Induced Changes in Ventricular Repolarization Artículo de revista

En: Journal of Electrocardiology, vol. 48, pp. 1081-1087, 2015.

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Mincholé, A; Bueno-Orovio, A; Laguna, P; Pueyo, E; Rodriguez, B

ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk Artículo de revista

En: Journal of Electrocardiology, vol. 48, pp. 867-873, 2015.

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Vicente, J; Johannesen, L; Mason, J W; Crumb, W J; Pueyo, E; Stockbridge, N; Strauss, D G

Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil Artículo de revista

En: J Am Heart Assoc, vol. 4, no e001615, pp. 1-13, 2015.

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Ramírez, J; Monasterio, V; Mincholé, A; Llamedo, M; Lenis, G; Cygankiewicz, I; Luna, Bayés A; Malik, M; Martínez, J P; Laguna, P; Pueyo, E

Automatic SVM classification of Sudden Cardiac Death and Pump Failure Death from Autonomic and Repolarization ECG Markers Artículo de revista

En: Journal of Electrocardiology, vol. 48, pp. 551-557, 2015.

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Conferencias

Monasterio, V; Carro, J; Pueyo, E; Rodríguez, J F

The Role of Purkinje Automaticity as an Arrhythmia Mechanism in Hyperkalaemia Conferencia

XLII International Conference on Computing in Cardiology, Nice, France, 2015.

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Vicente, J; Johannesen, L; Mason, J W; Crumb, W J; Pueyo, E; Stockbridge, N; Strauss, D G

Comprehensive Analysis of Novel Electrocardiographic Device Algorithms for Differentiating Arrhythmic Risk Conferencia

FDA Science Forum, Silver Spring, MD, 2015.

BibTeX

Vicente, J; Johannesen, L; Mason, J W; Pueyo, E; Stockbridge, N; Strauss, D G

Sex-Differences in Drug-Induced Changes in Ventricular Repolarization Conferencia

International Society of Computerized Electrocardiology, San Jose, California, US, 2015.

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Caiani, E G; Martín-Yebra, A; Pellegrini, A; Bolea, J; Auricchio, A; Pueyo, E; Vaida, P

High protein intake supplementation to compensate changes in ventricular repolarization due to 21-days of bedridden immobilization Conferencia

ESC; European Heart Journal, 2015.

BibTeX

2014

Artículos de revista

Lázaro, J; Alcaine, A; Romero, D; Gil, E; Laguna, P; Pueyo, E; Bailón, R

Electrocardiogram Derived Respiratory Rate from QRS Slopes and R-wave Angle Artículo de revista

En: Annals Biomedical Enginnering, vol. 40, no 10, pp. 2072–2083, 2014.

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Sánchez, C; Bueno-Orovio, A; Wettwer, E; Loose, S; Ravens, U; Pueyo, E; Rodríguez, B

Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation Artículo de revista

En: PLOS ONE, vol. 9, no 8, pp. e105897, 2014.

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Mincholé, A; Zacur, E; Pueyo, E; Laguna, P

Modeling and Quantification of Repolarization Feature Dependency on Heart Rate Artículo de revista

En: Selected paper for the Special 2013 issue of methods of information in medicine, vol. 53, no 4, pp. 324-328, 2014.

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Meijs, L P B; Galeotti, L; Pueyo, E; Romero, D; Jennings, R B; Ringborn, M; Warren, S G; Wagner, G S; Strauss, D G

An Electrocardiographic Sign of Ischemic Preconditioning Artículo de revista

En: Am J Physiol Heart Circ Physiol, vol. 307, pp. H80-H87, 2014.

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Bueno-Orovio, A; Sánchez, C; Pueyo, E; Rodriguez, B

Na/K pump regulation of cardiac repolarization: insights from a systems biology approach Artículo de revista

En: Eur J Physiol. INVITED REVIEW., vol. 466, pp. 183–193, 2014.

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Ramírez, J; Laguna, P; Luna, Bayés A; Malik, M; Pueyo, E

QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure: Relation to sudden cardiac death Artículo de revista

En: Journal of Electrocardiology, vol. 47, pp. 842– 848, 2014.

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Conferencias

Valenza, G; Orini, M; Citi, L; Minchole, A; Pueyo, E; Laguna, P; Barbieri, R

Assessing Instantaneous QT Variability dynamics within a Point-Process Nonlinear Framework Conferencia

8th CONFERENCE OF THE EUROPEAN STUDY GROUP ON CARDIOVASCULAR OSCILLATIONS, 2014.

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Bolea, J; Pueyo, E; Laguna, P; Bailón, R

Non-linear HRV indices under autonomic nervous system blockade Conferencia

36nd Annual International Conference of the IEEE EMBS, 2014.

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Valenza, G; Orini, M; Citi, L; Minchole, A; Pueyo, E; Laguna, P; Barbieri, R

Assessing Real-Time RR-QT Frequency-Domain Measures of Coupling and Causality through Inhomogeneous Point-Process Bivariate Models Conferencia

36nd Annual International Conference of the IEEE EMBS, 2014.

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Carro, J; Rodríguez, J F; Pueyo, E

In Silico Simulations of Experimental Protocols for Cardiac Modeling Conferencia

36nd Annual International Conference of the IEEE EMBS, 2014.

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Romero, D; Behar, N; Martín-Yebra, A; Martínez, J P; Laguna, P; Pueyo, E; Carrault, G; Mabo, P; Hernández, A

Analysis of QRS Alterations during Stress Test Recordings on Patients with Brugada Syndrome Conferencia

XLI International Conference on Computing in Cardiology, 2014.

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300 registros « 7 de 10 »