Faculty Member

Call: +34 976 76 2963

Email: epueyo@unizar.es

Address: Mariano Esquillor s/n, 50018, Zaragoza (Spain) (Spain)

ABOUT ME

Esther Pueyo received the M.S. degree in Mathematics from the University of Zaragoza, Spain, in 1999. During 2000, she was a research student at the Department of Mathematics, University of Zaragoza, where she developed a minor thesis in the field of Calculus, supervised by Prof. José Garay. In 2001 she started her Ph.D. studies in Biomedical Engineering at the University of Zaragoza under the supervision of Prof. Pablo Laguna, with a grant supported by the Spanish government. Her Ph.D. studies aimed at developing signal processing techniques applied to the electrocardiogram with the purpose of investigating conditions predisposing to suffer cardiac arrhythmias. During that time, she also worked as an Assistant Professor of Signal Processing at the Department of Electronic Engineering and Communications and she was a visiting scholar at research centers in Portugal, Argentina and UK, with long research visits at St. George’s Hospital Medical School, London, UK, where she worked under the supervision of Prof. Marek Malik.

After finishing her PhD in December 2006, she moved to the University of Oxford, UK (2007-2009) to get postdoctoral training in computational modeling and simulation of cardiac electrophysiology. She worked with Dr. Blanca Rodríguez and Prof. Kevin Burrage in the construction of cell and tissue models to investigate cardiac pathologies and drug-induced effects associated with increased arrhythmic risk. Most of the studies conducted during her postdoctoral period involved collaborations with experts in cardiology and experimental physiology, mainly from Hungary, UK and Sweden.

In January 2011 she was appointed Associate Professor at the University of Zaragoza, Spain. During 2012-2015 she worked as Senior Researcher at the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) after having been awarded with a ‘Ramón y Cajal’ Senior Research fellowship by the Spanish government. At the University of Zaragoza and CIBER-BBN, she works with a group of postdoctoral researchers and PhD, MSc and undergraduate students in the development of methodologies for the analysis of simulated, experimental and clinical data. By combining ECG signal processing and electrophysiological modeling and simulation tools, her current research aims at shedding light on the mechanisms and manifestations of cardiac arrhythmias at scales ranging from cellular ion channels to the electrocardiogram and on the role of important modulators such as the Autonomic Nervous System.

Since October 2015 she is back to her Associate Professor position at the University of Zaragoza. She has participated as Principal Investigator and as Collaborator in different international, European, national and regional research projects. She is currently PI of the ERC Starting Grant project MODELAGE, funded with 1.5 M€, in which a systems biology approach is used to investigate the aging of the human heart.

PUBLICATIONS
310 registros « 9 de 11 »

2012

Conferencias

Sánchez, C; Krueger, M W; Seemann, G; Dössel, O; Pueyo, E; Rodriguez, B

Ionic Modulation of Atrial Fibrillation Dynamics in a Human 3D Atrial Model Conferencia

XXXIX International Conference on Computing in Cardiology, Kracow, Poland, 2012.

Enlaces | BibTeX

Ramírez, J; Mincholé, A; Laguna, P; Pueyo, E

Characterization of Cardiac Repolarization Response to Heart Rate Changes Provoked by a Tilt Test Conferencia

XXXIX International Conference on Computing in Cardiology, Kracow, Poland, 2012.

Enlaces | BibTeX

Meijs, L P B; Galeotti, L; Pueyo, E; Romero, D; Jennings, R B; Wagner, G S; Strauss, D G

Increased T-amplitude with decreased ST-elevation characterizes ischemic preconditioning: A Simulation, Experimental and Clinical Study Conferencia

ISCE 2012 Annual Meting, Harrisburg, USA, 2012.

BibTeX

Sánchez, C; Bueno-Orovio, A; Pueyo, E; Rodriguez, B

Analysis of Populations of Human Atrial Models Reveals the Relative Importance of Ionic Conductances in the Different Stages of Repolarization Conferencia

36th meeting of the European Working Group of Cardiac Cellular Electrophysiology, Nantes, France, 2012.

BibTeX

Ramírez, J; Mincholé, A; Laguna, P; Pueyo, E

Caracterización de la Respuesta de la Repolarización a Cambios en el Ritmo Cardiaco Provocados por una Prueba de “Tilt” Conferencia

Proceedings XXX Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB), 2012, ISBN: 10:84-616-2147-6; 13:978-84-616-2147-7.

Enlaces | BibTeX

Bolea, J; Almeida, R; Pueyo, E; Laguna, P; Caiani, E

Ventricular Repolarization Adaptation to Abrupt Changes in Heart Rate after Microgravity Simulation by 5‐days Head‐Down Bed Rest Conferencia

Life in Space for Life on Earth, 12th European life Science symposium, Aberdeen, 2012.

Enlaces | BibTeX

2011

Artículos de revista

Romero, D; Ringborn, M; Laguna, P; Palhm, O; Pueyo, E

Depolarization changes during acute myocardial ischemia by evaluation of QRS slopes. Standard lead and vectorial approach Artículo de revista

En: IEEE Transactions Biomedical Engineering, vol. 58, pp. 110-120, 2011.

Enlaces | BibTeX

Mincholé, A; Pueyo, E; Rodríguez, J F; Zacur, E; Doblaré, M; Laguna, P

Quantification of Restitution Dispersion from the Dynamic Changes of the T wave peak to end, measured at the Surface ECG Artículo de revista

En: IEEE Transactions Biomedical Engineering, vol. 58, no 5, pp. 1172-1182, 2011.

Enlaces | BibTeX

Ringborn, M; Romero, D; Pueyo, E; Pahlm, O; Wagner, G S; Laguna, P; Platonov, P G

Evaluation of depolarization changes during acute myocardial ischemia by analysis of QRS slopes Artículo de revista

En: Journal of Electrocardiology, vol. 44, pp. 416-424, 2011.

Enlaces | BibTeX

Carro, J; Rodriguez, J F; Laguna, P; Pueyo, E

A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalemic conditions Artículo de revista

En: Phil Trans Royal Soc A, vol. 369, pp. 4205-4232, 2011.

Enlaces | BibTeX

Pueyo, E; Corrias, A; Virág, L; Jost, N; Szel, T; Varró, A; Szentandrássy, N; Nánási, P; Burrage, K; Rodriguez, B

A multiscale investigation of repolarization variability and its role in cardiac arrhythmogenesis Artículo de revista

En: Biophys J, vol. 101, no 12, pp. 2892-2902, 2011.

Enlaces | BibTeX

Conferencias

Bolea, J; Pueyo, E; Almeida, R; Llamedo, M; Sotaquira, M; Martínez, J P; Laguna, P; Caiani, E G

Influence of simulated microgravity by Head-Down-Bed-Resting on QT/RR Dynamics Conferencia

XXXVIII International Conference on Computing in Cardiology, Hangzhou, China, 2011.

Enlaces | BibTeX

Alcaine, A; Bailón, R; Romero, D; Pueyo, E; Laguna, P

Very-Low-Frequency Modulation of QRS slopes in Patients with Angina Pectoris. Conferencia

XXXVIII International Conference on Computing in Cardiology, Hangzhou, China, 2011.

Enlaces | BibTeX

Sánchez, C; Rodriguez, B; Pueyo, E

Ionic Modulators of Electrophysiology and Re-entry Properties in Human Atria Conferencia

XXXVIII International Conference on Computing in Cardiology, Hangzhou, China, 2011.

Enlaces | BibTeX

Bolea, J; Pueyo, E; Almeida, R; Sotaquira, M; Llamedo, M; Martínez, J P; Laguna, P; Caiani, E G

Microgravedad simulada mediante Head-Down-Bed-Resting y su influencia en la dinámica del QT/RR Conferencia

Proceedings XXIX Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB), 2011.

Enlaces | BibTeX

Romero, D; Ringborn, M; Pueyo, E; Palhm, O; Wagner, G S; Laguna, P; Platanov, P

Análisis de la despolarización en isquemia de miocardio mediante la evaluación de las pendientes del QRS Conferencia

Proceedings XXIX Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB), 2011.

Enlaces | BibTeX

Romero, D; Ringborn, M; Laguna, P; Pahlm, O; Pueyo, E

Análisis Espacial en la Evaluación de Cambios de la Despolarización Cardíaca durante Isquemia Aguda de Miocardio Conferencia

V Latin American Congress on Biomedical Engineering CLAIB, 2011.

Enlaces | BibTeX

2010

Artículos de revista

Abramson, D; Bernabeu, M; Bethwaite, B; Burrage, K; Pueyo, E; Rodriguez, B; Sher, A; Tan, J

High-throughput cardiac science on the grid Artículo de revista

En: Philosophical Transactions of the Royal Society – A, vol. 368, pp. 3907-3923, 2010.

Enlaces | BibTeX

Corrias, A; Jie, X; Romero, L; Bishop, M; Bernabeu, M; Pueyo, E; Rodriguez, B

Arrhythmic Risk Biomarkers for the Assessment of Drug Cardiotoxicity: from experiments to computer simulations Artículo de revista

En: Philosophical Transactions of the Royal Society – A, vol. 368, pp. 3001-3025, 2010.

Enlaces | BibTeX

Pueyo, E; Husti, Z; Hornyik, T; Baczkó, I; Laguna, P; Varró, A; Rodriguez, B

Mechanisms of ventricular rate adaptation as a predictor of arrhythmic risk Artículo de revista

En: American Journal of Physiology, vol. 298, pp. H1577-H1587, 2010.

Enlaces | BibTeX

Conferencias

Corrias, A; Pueyo, E; Burrage, K; Rodriguez, B

Causes of variability in Repolarization: From isolated cells to ECG Conferencia

31st Annual Conference, Heart Rhythm, vol. 7, no 5, 2010.

Enlaces | BibTeX

Sánchez, C; Corrias, A; Laguna, P; Pueyo, E; Rodriguez, B

Sensitivity of Atrial Fibrillation Related Biomarkers to changes in Ionic Current Properties Conferencia

31st Annual Conference, Heart Rhythm, vol. 7, no 5, 2010.

Enlaces | BibTeX

Pueyo, E

QT/RR adaptation Conferencia

THEW Newsletter Issue 10. QT evaluation for drugs with autonomic effects (PART II): QT/RR relationship and QT hysteresis, 2010.

BibTeX

Jie, X; Rodriguez, B; Pueyo, E

A New ECG Biomarker for Drug Toxicity: a Combined Signal Processing and Computational Modeling Study Conferencia

32nd Annual International Conference of the IEEE EMBS, Buenos Aires, Argentina, 2010.

Enlaces | BibTeX

Jie, X; Rodriguez, B; Pueyo, E

Torsadogenic Drug-Induced Increased Short-term Variability of JT-area Conferencia

XXXVII International Conference on Computing in Cardiology, Belfast, UK, 2010.

Enlaces | BibTeX

Romero, D; Ringborn, M; Laguna, P; Pahlm, O; Pueyo, E

A Vectorial Approach for Evaluation of Depolarization Changes during Acute Myocardial Ischemia Conferencia

XXXVII International Conference on Computers in Cardiology, Belfast, UK, 2010.

Enlaces | BibTeX

Sánchez, C; Corrias, A; Laguna, P; Davies, M; Swinton, J; Jacobson, I; Pueyo, E; Rodriguez, B

Potential Pharmacological Therapies for Atrial Fibrillation. A Computational Study Conferencia

XXXVII International Conference on Computers in Cardiology, Belfast, UK, 2010.

Enlaces | BibTeX

Mincholé, A; Pueyo, E; Rodriguez, J F; Zacur, E; Doblaré, M; Laguna, P

Evaluation of a Method for Quantification of Restitution Dispersion from the surface ECG Conferencia

XXXVII International Conference on Computers in Cardiology, Belfast, UK, 2010.

Enlaces | BibTeX

Carro, J; Rodriguez, J F; Laguna, P; Pueyo, E

Analysis and Improvement of a Human Ventricular Cell Model for Investigation of Cardiac Arrhythmias Conferencia

XXXVII International Conference on Computers in Cardiology, Belfast, UK, 2010.

Enlaces | BibTeX

Almeida, R; Martínez, J P; Rocha, A P; Laguna, P; Pueyo, E

P Wave Delineation Using Spatially Projected Leads From Wavelet Transform Loops Conferencia

XXXVII International Conference on Computers in Cardiology, Belfast, UK, 2010.

Enlaces | BibTeX

310 registros « 9 de 11 »