Address

Mariano Esquillor s/n, 50018, Zaragoza (Spain)

Contact Information

Call: +34 976 76 2963

Email: epueyo@unizar.es

Esther Pueyo Paules

Faculty Member

Website

http://www.estherpueyo.com

Biography

Esther Pueyo received the M.S. degree in Mathematics from the University of Zaragoza, Spain, in 1999. During 2000, she was a research student at the Department of Mathematics, University of Zaragoza, where she developed a minor thesis in the field of Calculus, supervised by Prof. José Garay. In 2001 she started her Ph.D. studies in Biomedical Engineering at the University of Zaragoza under the supervision of Prof. Pablo Laguna, with a grant supported by the Spanish government. Her Ph.D. studies aimed at developing signal processing techniques applied to the electrocardiogram with the purpose of investigating conditions predisposing to suffer cardiac arrhythmias. During that time, she also worked as an Assistant Professor of Signal Processing at the Department of Electronic Engineering and Communications and she was a visiting scholar at research centers in Portugal, Argentina and UK, with long research visits at St. George’s Hospital Medical School, London, UK, where she worked under the supervision of Prof. Marek Malik.

After finishing her PhD in December 2006, she moved to the University of Oxford, UK (2007-2009) to get postdoctoral training in computational modeling and simulation of cardiac electrophysiology. She worked with Dr. Blanca Rodríguez and Prof. Kevin Burrage in the construction of cell and tissue models to investigate cardiac pathologies and drug-induced effects associated with increased arrhythmic risk. Most of the studies conducted during her postdoctoral period involved collaborations with experts in cardiology and experimental physiology, mainly from Hungary, UK and Sweden.

In January 2011 she was appointed Associate Professor at the University of Zaragoza, Spain. During 2012-2015 she worked as Senior Researcher at the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) after having been awarded with a ‘Ramón y Cajal’ Senior Research fellowship by the Spanish government. At the University of Zaragoza and CIBER-BBN, she works with a group of postdoctoral researchers and PhD, MSc and undergraduate students in the development of methodologies for the analysis of simulated, experimental and clinical data. By combining ECG signal processing and electrophysiological modeling and simulation tools, her current research aims at shedding light on the mechanisms and manifestations of cardiac arrhythmias at scales ranging from cellular ion channels to the electrocardiogram and on the role of important modulators such as the Autonomic Nervous System.

Since October 2015 she is back to her Associate Professor position at the University of Zaragoza. She has participated as Principal Investigator and as Collaborator in different international, European, national and regional research projects. She is currently PI of the ERC Starting Grant project MODELAGE, funded with 1.5 M€, in which a systems biology approach is used to investigate the aging of the human heart.

Publications

236 registros « 1 de 5 »

2022

Artículos de revista

García-Mendívil, L; Pérez-Zabalza, M; Mountris, K; Duwé, S; Smisdom, N; Pérez, M; Luján, L; Wolfs, E; Driesen, R B; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Vázquez-Sancho, M; Matamala-Adell, M; Sorribas-Berjón, J F; Bellido-Morales, J A; Mancebón-Sierra, F J; Vaca-Núñez, A S; Ballester-Cuenca, C; Oliván-Viguera, A; Diez, E; Ordovás, L; Pueyo, E

Analysis of age-related left ventricular collagen remodeling in living donors: implications in arrhythmogenesis Artículo de revista

En: iScience, 2022.

Enlaces | BibTeX

Sánchez, F J; Pueyo, E; Diez, E R

Strain echocardiography to predict postoperative atrial fibrillation Artículo de revista

En: Int. J. Mol. Sci., 23 , pp. 1355, 2022.

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Bukhari, H A; Sánchez, C; Srinivasan, S; Palmieri, F; Potse, M; Laguna, P; Pueyo, E

Estimation of Potassium Levels in Hemodialysis Patients by T wave Nonlinear Dynamics and Morphology Markers Artículo de revista

En: Computers in Biology and Medicine, In press, 2022.

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Palmieri, F; Gomis, P; Ferreira, D; Pueyo, E; Martínez, J P; Laguna, P; Ramírez, J

Weighted Time Warping Improves T-wave Morphology Markers Clinical Significance Artículo de revista

En: IEEE Trans Biomed Eng, 2022.

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2021

Artículos de revista

Barrio, R; Martínez, M A; Pueyo, E; Serrano, S

Dynamical analysis of early afterdepolarization patterns in a biophysically-detailed cardiac model Artículo de revista

En: Chaos, 31 (073137), pp. 1-20, 2021.

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Ramos-Marquès, E; García-Mendívil, L; Pérez-Zabalza, M; Santander-Badules, H; Srinivasan, S; Oliveros, J C; Torres-Pérez, R; Cebollada, A; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Vázquez-Sancho, M; Matamala-Adell, M; Sorribas-Berjón, J F; Bellido-Morales, J A; Mancebón-Sierra, F J; Vaca-Núñez, A S; Ballester-Cuenca, C; Jiménez-Navarro, M; Villaescusa, J M; Garrido-Huéscar, E; Segovia-Roldán, M; Oliván-Viguera, A; Gómez-González, C; Muñiz, G; Diez, E; Ordovás, L; Pueyo, E

Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution Artículo de revista

En: Aging Cell, 00:e13383 , pp. 1-16, 2021.

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Palmieri, F; Gomis, P; Ruiz, J E; Ferreira, D; Martín-Yebra, A; Pueyo, E; Martínez, J P; Ramírez, J; Laguna, P

Nonlinear T-wave Time Warping-based Sensing Model for Non-invasive Personalized Blood Potassium Monitoring in Hemodialysis Patients Artículo de revista

En: Sensors, 21 (2710), 2021.

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Bukhari, H A; Palmieri, F; Ramirez, J; Laguna, P; Ruiz, J E; Ferreira, D; Potse, M; Sánchez, C; Pueyo, E

Characterization of T Wave Amplitude, Duration and Morphology Changes During Hemodialysis: Relationship with Serum Electrolyte Levels and Heart Rate Artículo de revista

En: IEEE Trans Biomed Eng, 68 (8), pp. 2467-2478, 2021.

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Palmieri, F; Gomis, P; Ferreira, D; Ruiz, J E; Bergasa, B; Martín-Yebra, A; Bukhari, H A; Pueyo, E; Martínez, J P; Ramírez, J; Laguna, P

Monitoring Blood Potassium Concentration in Hemodialysis Patients by Quantifying T-wave Morphology Dynamics Artículo de revista

En: Scientific reports, 11 (3883), 2021.

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Hernández-Vicente, A; Hernando, D; Vicente-Rodríguez, G; Bailón, R; Garatachea, N; Pueyo, E

ECG ventricular repolarization dynamics during exercise: temporal profile, relation to heart rate variability and effects of age and physical health Artículo de revista

En: International Journal of Environmental Research and Public Health, 18 (9497), 2021.

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Hernández-Vicente, A; Hernando, D; Marín-Puyalto, J; Vicente-Rodríguez, G; Garatachea, N; Pueyo, E; Bailón, R

Validity of the Polar H7 Heart Rate Sensor for Heart Rate Variability Analysis during Exercise in Different Age, Body Composition and Fitness Level Groups Artículo de revista

En: Sensors, 21 (902), 2021.

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Mountris, K A; Pueyo, E

A dual adaptive explicit time integration algorithm for efficiently solving the cardiac monodomain equation Artículo de revista

En: Int J Numer Meth Biomed Engng, e3461 , 2021.

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Segovia-Roldán, M; Diez, E R; Pueyo, E

Melatonin to rescue the aged heart: antiarrhythmic and antioxidant benefits. Oxidative Medicine and Cellular Longevity Artículo de revista

En: Oxidative Medicine and Cellular Longevity, ID 8876792 , pp. 1-18, 2021.

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Palacios, S; Cygankiewicz, I; de Luna, A Bayés; Pueyo, E; Martínez, J P

Periodic Repolarization Dynamics as Predictor of Risk for Sudden Cardiac Death in Chronic Heart Failure Patients Artículo de revista

En: Scientific Reports, 11:20546 , 2021.

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Palmieri, F; Gomis, P; Ruiz, J E; Ferreira, D; Martín-Yebra, A; Pueyo, E; Martínez, J P; Ramírez, J; Laguna, P

ECG-based Monitoring of Blood Potassium Concentration: Periodic versus Principal Componentas Lead Transformation for Biomarker Robustness Artículo de revista

En: Biomedical Signal Processing and Control, 68 (102719), pp. 1-11, 2021.

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Taggart, P; Pueyo, E; Duijvenboden, S V.; Porter, B; Bishop, M; Sampedro-Puente, D A; Orini, M; Hanson, B; Rinaldi, C A; Gill, J S; Lambiase, P

Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia Artículo de revista

En: Europace, euab009 , 2021.

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del Castillo, M González; Hernando, D; Orini, M; Laguna, P; Viik, J; Bailón, R; Pueyo, E

QT variability unrelated to RR variability during stress testing for identification of coronary artery disease Artículo de revista

En: Phil. Trans. R. Soc. A., 379: 20200261 , 2021.

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Celotto, C; Sanchez, C; Mountris, K A; Laguna, P; Pueyo, E

Location of Parasympathetic Innervation Regions from Electrograms to Guide Atrial Fibrillation Ablation Therapy: An In Silico Modeling Study Artículo de revista

En: Frontiers in Physiology, 12 (674197), 2021.

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Sampedro-Puente, D A; Raphel, F; Fernandez-Bes, J; Laguna, P; Lombardi, D; Pueyo, E

Characterization of Spatio-Temporal Cardiac Action Potential Variability at Baseline and under Beta-Adrenergic Stimulation by Combined Unscented Kalman Filter and Double Greedy Dimension Reduction Artículo de revista

En: IEEE Journal of Biomedical and Health Informatics, 25 (1), pp. 276-288, 2021.

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Bragard, J R; Camara, O; Echebarria, B; Giorda, L Gerardo; Pueyo, E; Saiz, J; Sebastián, R; Soudah, E; Vázquez, M

Cardiac Computational Modelling Artículo de revista

En: Rev Esp Cardiol, 74 (1), pp. 65-71, 2021.

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Milagro, J; Hernández-Vicente, A; Hernando, D; Casajús, J A; Garatachea, N; Bailón, R; Pueyo, E

Estimation of the second ventilatory threshold through ventricular repolarization profile analysis Artículo de revista

En: Scand J Med Sci Spo, 31 , pp. 339-349, 2021.

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Conferencias

Smisdom, N; Duwe, S; Mountris, K; Srinivasan, S; Pérez, M; Luján, L; Wolfs, E; Driesen, R B; Olivan-Viguera, A; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Vázquez-Sancho, M; Matamala-Adell, M; Sorribas-Berjón, F; Ballester-Cuenca, C; Diez, E; Ordovás, L; Pueyo, E

Caracterización del remodelado cardiaco asociado a la edad en el ventrículo izquierdo humano Conferencia

Primer congreso anual de estudiantes de doctorado de la Universidad Miguel Hernández. Comunicación oral, 2021.

BibTeX

Celotto, C; Sánchez, C; Mountris, K A; Laguna, P; Pueyo, E

Efectos Transitorios y en Estado Estacionario del Bloqueo del Canal SK y de la Estimulación Adrenérgica para Contrarrestar los Efectos Arritmogénicos Inducidos por Acetilcolina en la Aurícula Humana: un Estudio Computacional Conferencia

X Jornada de Jóvenes Investigadores I3A. Comunicación oral, 2021.

Enlaces | BibTeX

Pérez-Martínez, A; Oliván-Viguera, A; Pueyo, E

Contribución de los canales SK a la electrofisiología ventricular humana en pacientes con insuficiencia cardíaca Conferencia

X Jornada de Jóvenes Investigadores I3A. Comunicación oral, 2021.

Enlaces | BibTeX

Bukhari, H A; Sánchez, C; Potse, M; Laguna, P; Pueyo, E

Estimación del nivel de potasio en sangre mediante las pendientes del QRS del electrocardiograma en pacientes renales crónicos Conferencia

X Jornada de Jóvenes Investigadores I3A. Comunicación oral, 2021.

Enlaces | BibTeX

Rosales, R M; Mountris, K; Doblaré, M; Mazo, M; Pueyo, E

Evaluación Computacional de la Arquitectura de la Matriz de Cultivo en la Electrofisiología Cardíaca Conferencia

X Jornada de Jóvenes Investigadores I3A. Comunicación oral, 2021.

Enlaces | BibTeX

Rosales, R M; Mountris, K; Doblaré, M; Mazo, M; Pueyo, E

In silico Electrophysiological Evaluation of Scaffold Geometries for Cardiac Tissue Engineering Conferencia

Proceedings of the XLVII International Conference on Computing in Cardiology, Brno, Czech Republic, 2021.

BibTeX

Pérez-Martínez, C; Martín-Yebra, A; Viik, J; Martínez, J P; Pueyo, E; Laguna, P

Spatial ECG filtering by Periodic component analysis for improved QT delineation in stress test recordings Conferencia

55th Asilomar Conference on Signals, Systems and Computers, 2021.

Enlaces | BibTeX

Pérez-Martínez, C; Pueyo, E; Martínez, J P; Laguna, P

Characterization of impaired repolarization by quantification of the QT delay in response to heart rate changes from stress test recordings Conferencia

International Society for Computerized Electrocardiology -ISCE-2020, 2021.

BibTeX

Cebollada, R; Pérez-Martínez, C; Mountris, K; Martínez, J P; Laguna, P; Pueyo, E

Mechanisms Underlying QT Interval Adaptation Behind Heart Rate During Stress Test Conferencia

Proceedings of the XLVII International Conference on Computing in Cardiology, Brno, Czech Republic, 2021.

BibTeX

Pérez-Martínez, C; Pueyo, E; Martínez, J P; Laguna, P

Mejora de la delineación del intervalo QT en señales ECG grabadas durante prueba de esfuerzo Conferencia

X Jornada de Jóvenes Investigadores I3A. Comunicación oral, 2021.

Enlaces | BibTeX

García-Mendívil, L; Hernández, N; Sánchez, M; Pérez-Zabalza, M; Garrido-Huéscar, E; Oliveros, J C; Torres, R; Ramos, E; Pueyo, E; Ordovás, L

Envejecimiento cardiaco humano: transcriptómica y desarrollo de modelos celulares de envejecimiento Conferencia

X Jornada de Jóvenes Investigadores I3A. Comunicación oral, 2021.

Enlaces | BibTeX

García-Mendívil, L; Hernández, N; Sánchez, M; Pérez-Zabalza, M; Garrido-Huéscar, E; Oliveros, J C; Torres, R; Ramos, E; Pueyo, E; Ordovás, L

In vivo and in vitro cardiac aging: developing of cellular aging models Conferencia

XIX Congreso de la Sociedad Española de Biología Celular. Póster, 2021.

BibTeX

Palacios, S; Cygankiewicz, I; Bayés-de-Luna, A; Martínez, J P; Pueyo, E

Estudio de la dinámica periódica de la repolarización para la predicción de muerte súbita en pacientes con insuficiencia cardíaca crónica Conferencia

I Congreso Anual de Estudiantes de Doctorado (CAED), Universidad Miguel Hernandez, Elche 2021.

Enlaces | BibTeX

Gómez, M; Carro, J; Pueyo, E; Monasterio, V

Modificación de un modelo de miocito ventricular humano para representar el papel de los canales SK en insuficiencia cardiaca Conferencia

XXXIX Congreso de la Sociedad Española de Ingeniería Biomédica CASEIB, Madrid, España, 2021.

Enlaces | BibTeX

Palmieri, F; Gomis, P; Ruiz, J E; Ferreira, D; Pueyo, E; Martínez, J P; Laguna, P; Ramírez, J

Time-Warping” ponderado sobre la onda T para Reducir el Impacto de Errores de Delineación: Implicaciones Clínicas Conferencia

XXXIX Congreso de la Sociedad Española de Ingeniería Biomédica CASEIB, Madrid, España, 2021.

Enlaces | BibTeX

Bukhari, H A; Laguna, P; Potse, M; Sánchez, C; Pueyo, E

QRS Slopes for Potassium and Calcium Monitoring in End-Stage Renal Disease Patients Conferencia

Proceedings of the XLVII International Conference on Computing in Cardiology, Brno, Czech Republic, 2021.

BibTeX

Palmieri, F; Gomis, P; Ruiz, J E; Ferreira, D; Pueyo, E; Martínez, J P; Laguna, P; Ramírez, J

Weighted Time Warping T-wave Analysis Robust to Delineation Errors: Clinical Implications Conferencia

Proceedings of the XLVII International Conference on Computing in Cardiology, Brno, Czech Republic, 2021.

BibTeX

Celotto, C; Sánchez, C; Mountris, K; Laguna, P; Pueyo, E

Rotor Termination in Cholinergic Paroxysmal Atrial Fibrillation by Small-Conductance Calcium-Activated K+ Channels Inhibition and Isoproterenol: a Computational Study Conferencia

Proceedings of the XLVII International Conference on Computing in Cardiology, Brno, Czech Republic, 2021.

BibTeX

García, D; Kontaxis, S; Hernández-Vicente, A; Hernando, D; Milagro, J; Pueyo, E; Garatachea, N; Bailón, R; Lázaro, J

Ventilatory Thresholds Estimation Based on ECG-derived Respiratory Rate Conferencia

Proceedings of the XLVII International Conference on Computing in Cardiology, Brno, Czech Republic, 2021.

BibTeX

Pérez, M; García-Mendívil, L; Mountris, K; Smisdom, N; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Matamala-Adell, M; Vázquez-Sancho, M; Mancebón-Sierra, F Javier; Vaca-Núñez, A Sebastián; Ballester-Cuenca, C; Olivan-Viguera, A; Ordovás, L; Pueyo, E

Age-associated changes in fibrosis amount and spatial organization and its effects on human ventricular electrophysiology Conferencia

Proceedings of the XLVII International Conference on Computing in Cardiology, Brno, Czech Republic, 2021.

BibTeX

2020

Artículos de revista

Barrio, R; Martínez, M A; Pérez, L; Pueyo, E

Bifurcations and slow-fast analysis in a cardiac cell model for investigation of early afterdepolarizations Artículo de revista

En: Mathematics, 8 (6), pp. 880, 2020.

Enlaces | BibTeX

Barrio, R; Coombes, S; Fenton, Desrochesand M F; Luther, S; Pueyo, E

Excitable Dynamics in Neural and Cardiac Systems Artículo de revista

En: Communications in Nonlinear Science and Numerical Simulation, 2020.

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Prado, N J; Muñoz, E M; Farias-Altamirano, L E; Aguiar, F; Ponce-Zumino, A Z; Sánchez, F J; Miatello, R M; Pueyo, E; Diez, E R

Reperfusion Arrhythmias Increase After Superior Cervical Ganglionectomy Due To Conduction Disorders And Changes In Repolarisation Artículo de revista

En: International Journal of Molecular Sciences, 21 (5), pp. 1804, 2020.

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Lozano-Gerona, J; Olivan-Viguera, A; Delgado-Wicke, P; Singh, V; Brown, B M; Tapia-Casellas, E; Pueyo, E; Valero, Sofía M; Garcia-Otín, A L; Giraldo, P; Abarca-Lachen, E; Surra, J C; Osada, J; Hamilton, K L; Raychaudhuri, S P; Marigil, M; Juarranz, A; Wulff, H; Miura, H; Gilaberte, Y; Köhler, R

Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis Artículo de revista

En: PlosOne, 15 (3), pp. e0222619, 2020.

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Hernández-Vicente, A; Hernando, D; Santos-Lozano, A; Rodríguez-Romo, G; Vicente-Rodríguez, G; Pueyo, E; Bailón, R; Garatachea, N

Heart rate variability and exceptional longevity Artículo de revista

En: Frontiers in Physiology, 2020.

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Mountris, K A; Pueyo, E

The Radial Point Interpolation Mixed Collocation Method (RPIMC) for the solution of transient diffusion problems Artículo de revista

En: Eng Anal Bound Elem, 121 , pp. 207–216, 2020.

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Nanasi, P P; Pueyo, E; Virag, L

Editorial: Perspectives of Antiarrhythmic Drug Therapy: Disappointing Past, Current Efforts, and Faint Hopes Artículo de revista

En: Frontiers in Pharmacology, 2020.

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Oliván‑Viguera, A; Pérez‑Zabalza, M; García‑Mendívil, L; Mountris, K A; Orós‑Rodrigo, S; Ramos‑Marquès, E; Vallejo‑Gil, J M; Fresneda‑Roldán, P C; Fañanás‑Mastral, J; Vázquez‑Sancho, M; Matamala‑Adell, M; Sorribas‑Berjón, F; Bellido‑Morales, J A; Mancebón‑Sierra, F J; Vaca‑Núñez, A S; Ballester‑Cuenca, C; Marigil, M A; Pastor, C; Ordovás, L; Köhler, R; Diez, E; Pueyo, E

Minimally invasive system to reliably characterize ventricular electrophysiology from living donors Artículo de revista

En: Sci Rep, 10 (19941), 2020.

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Oliver-Gelabert, A; García-Mendívil, L; Vallejo-Gil, J M; Fresneda-Roldán, P C; Andelová, K; Fañanás-Mastral, J; Vázquez-Sancho, M; Matamala-Adell, M; Sorribas-Berjón, F; Ballester-Cuenca, C; Tribulova, N; Ordovás, L; Diez, E R; Pueyo, E

Automatic quantification of cardiomyocyte dimensions and connexin 43 lateralization in fluorescence images Artículo de revista

En: Biomolecules, 10 (9), pp. 1334, 2020.

Enlaces | BibTeX

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