Esther Pueyo Paules
Faculty Member
Website
Biography
Esther Pueyo received the M.S. degree in Mathematics from the University of Zaragoza, Spain, in 1999. During 2000, she was a research student at the Department of Mathematics, University of Zaragoza, where she developed a minor thesis in the field of Calculus, supervised by Prof. José Garay. In 2001 she started her Ph.D. studies in Biomedical Engineering at the University of Zaragoza under the supervision of Prof. Pablo Laguna, with a grant supported by the Spanish government. Her Ph.D. studies aimed at developing signal processing techniques applied to the electrocardiogram with the purpose of investigating conditions predisposing to suffer cardiac arrhythmias. During that time, she also worked as an Assistant Professor of Signal Processing at the Department of Electronic Engineering and Communications and she was a visiting scholar at research centers in Portugal, Argentina and UK, with long research visits at St. George’s Hospital Medical School, London, UK, where she worked under the supervision of Prof. Marek Malik.
After finishing her PhD in December 2006, she moved to the University of Oxford, UK (2007-2009) to get postdoctoral training in computational modeling and simulation of cardiac electrophysiology. She worked with Dr. Blanca Rodríguez and Prof. Kevin Burrage in the construction of cell and tissue models to investigate cardiac pathologies and drug-induced effects associated with increased arrhythmic risk. Most of the studies conducted during her postdoctoral period involved collaborations with experts in cardiology and experimental physiology, mainly from Hungary, UK and Sweden.
In January 2011 she was appointed Associate Professor at the University of Zaragoza, Spain. During 2012-2015 she worked as Senior Researcher at the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) after having been awarded with a ‘Ramón y Cajal’ Senior Research fellowship by the Spanish government. At the University of Zaragoza and CIBER-BBN, she works with a group of postdoctoral researchers and PhD, MSc and undergraduate students in the development of methodologies for the analysis of simulated, experimental and clinical data. By combining ECG signal processing and electrophysiological modeling and simulation tools, her current research aims at shedding light on the mechanisms and manifestations of cardiac arrhythmias at scales ranging from cellular ion channels to the electrocardiogram and on the role of important modulators such as the Autonomic Nervous System.
Since October 2015 she is back to her Associate Professor position at the University of Zaragoza. She has participated as Principal Investigator and as Collaborator in different international, European, national and regional research projects. She is currently PI of the ERC Starting Grant project MODELAGE, funded with 1.5 M€, in which a systems biology approach is used to investigate the aging of the human heart.
Publications
2023
Artículos de revista
Prevention of sudden death in sports: a global and multidisciplinary observatory for scientific research and knowledge transfer Artículo de revista
En: Reviews in Cardiovascular Medicine, vol. 24, iss. 1, no. 12, 2023.
The Role of β-adrenergic Stimulation in QT Interval Adaptation to Heart Rate During Stress Test Artículo de revista
En: Plos One, 2023.
En: Computers in Biology and Medicine, 2023.
QT Interval Time Lag in Response to Heart Rate Changes During Stress Test for Coronary Artery Disease Diagnosis Artículo de revista
En: Biomedical Signal Processing and Control, 2023.
2022
Artículos de revista
Strain echocardiography to predict postoperative atrial fibrillation Artículo de revista
En: Int. J. Mol. Sci., vol. 23, pp. 1355, 2022.
Weighted Time Warping Improves T-wave Morphology Markers Clinical Significance Artículo de revista
En: IEEE Trans Biomed Eng, 2022.
Monitoring of Serum Potassium and Calcium Levels in End-stage Renal Disease Patients by ECG Depolarization Morphology Analysis Artículo de revista
En: Sensors, vol. 22, no. 2951, 2022.
Meshless electrophysiological modeling of cardiac resynchronization therapy—benchmark analysis with finite-element methods in experimental data Artículo de revista
En: Applied Sciences, vol. 12, no. 6438, 2022.
Modelización matemática y simulación computacional de la variabilidad espacio-temporal en la actividad eléctrica cardíaca Artículo de revista
En: Rev. Real Academia de Ciencias, vol. 76, pp. 7-54, 2022, ISSN: 0370-3207.
Estimation of Potassium Levels in Hemodialysis Patients by T wave Nonlinear Dynamics and Morphology Markers Artículo de revista
En: Computers in Biology and Medicine, In press, 2022.
Fabrication of human myocardium using multidimensional modelling of engineered tissues Artículo de revista
En: Biofabrication, 2022.
Physical activity in centenarians beyond cut-point-based accelerometer metrics Artículo de revista
En: International Journal of Environmental Research and Public Health, 2022.
Cardiac cells stimulated with an axial current-like waveform reproduce electrophysiological properties of tissue fibers Artículo de revista
En: Computer Methods and Programs in Biomedicine, 2022.
Analysis of age-related left ventricular collagen remodeling in living donors: implications in arrhythmogenesis Artículo de revista
En: iScience, 2022.
Dynamical mechanism for generation of arrhythmogenic early afterdepolarizations in cardiac myocytes: Insights from in silico electrophysiological models Artículo de revista
En: Physical Review E., vol. 106, no. 024402, 2022.
A meshless fragile points method for rule-based definition of myocardial fiber orientation Artículo de revista
En: Computer Methods and Programs in Biomedicine, vol. 226, no. 107164, 2022.
A meshless fragile points method for the solution of the monodomain model for cardiac electrophysiology simulation Artículo de revista
En: Journal of Computational Science, vol. 65, no. 101880, 2022.
Conferencias
Assessment and optimization of conduction system pacing for anti-bradycardia pacemaker therapy Conferencia
STAFF-MALT Symposium 2022, Senohraby, Czech Republic, 2022.
XI Jornada de Jóvenes Investigadores del I3A, 2022.
Envejecimiento cardíaco humano: transcriptómica y desarrollo de modelos celulares Conferencia
II Congreso Anual de Estudiantes de Doctorado (CAED), Universidad Miguel Hernández, Elche, 2022.
Cambios en la despolarización y repolarización producidos por la estimulación de rama izquierda frente a la estimulación convencional Conferencia
Ritmo22, Granada, España, 2022.
Estimulación de rama izquierda frente a estimulación de ventrículo derecho: cambios en la despolarización y en la repolarización Conferencia
Congreso de la Salud Cardiovascular, Palma de Mallorca, España, 2022.
Jornadas de Jóvenes Investigadores del I3A, Zaragoza, España, 2022.
Effects of Acetylcholine Release Spatial Distribution on the Frequency of Atrial Reentrant Circuits: a Computational Study Conferencia
Proceedings of the XLVIII International Conference on Computing in Cardiology, Tampere, Finland, 2022.
Inter-individual differences in cell composition across the ventricular wall may explain variability in ECG response to serum potassium and calcium variations Conferencia
Proceedings of the XLVIII International Conference on Computing in Cardiology, Tampere, Finland, 2022.
An in Silico Investigation into the Role of SK Channels in Failing Ventricular Myocytes Conferencia
Proceedings of the XLVIII International Conference on Computing in Cardiology, Tampere, Finland, 2022.
Ventricular Conduction System Modeling for Electrophysiological Simulation of the Porcine Heart Conferencia
Proceedings of the XLVIII International Conference on Computing in Cardiology, Tampere, Finland, 2022.
Accelerating stabilization of whole-heart models after changes in cycle length Conferencia
Proceedings of the XLVIII International Conference on Computing in Cardiology, Tampere, Finland, 2022.
Right Ventricular vs Left Bundle Branch Pacing-Induced Changes in ECG Depolarization and Repolarization Conferencia
Proceedings of the XLVIII International Conference on Computing in Cardiology, Tampere, Finland, 2022.
XI Jornada de Jóvenes Investigadores e Investigadoras del I3A, Zaragoza, España, 2022.
Endothelin-1 enhances transmural heterogeneities in healthy porcine ventricular myocardium Conferencia
46th European Working Group on Cardiac Cellular Electrophysiology (EWGCCE), Toledo, España, 2022.
SK channels characterization in the human ventricle: differences in expression levels and electrophysiological role in non-diseased and heart failure ventricles Conferencia
46th European Working Group on Cardiac Cellular Electrophysiology (EWGCCE), Toledo, España, 2022.
SK channels contribution to ventricular electrophysiology in heart failure patients Conferencia
Frontiers in CardioVascular Biomedicine (FCVB), Cardiovascular Research, Volume 118, Issue Supplement_1, June 2022 Budapest, Hungría, 2022.
Endothelin-1 amplifies ventricular repolarization heterogeneities in chronic myocardial infarction pigs Conferencia
Frontiers in CardioVascular Biomedicine (FCVB), Cardiovascular Research, Volume 118, Issue Supplement_1, June 2022 Budapest, Hungría, 2022.
Caracterización del papel de los canales SK en el remodelado ventricular producido por insuficiencia cardíaca Conferencia
II Congreso Anual Internacional de Estudiantes de Doctorado (CAED), Elche, España, 2022.
Cell damage and apoptosis induced by TRPV4 activation in human melanoma cells and Hacat keratinocytes Conferencia
Reunión Anual de Sociedades de Biociencias 2022, Reunión conjunta SAIC SAI & FAIC SAFIS 2022, Medicina. Buenos Aires, Vol. 82 Supl. V - 2022 Buenos Aires, Argentina, 2022.
Development of new human models to determine age related cardiotoxicity of drugs Conferencia
Stem cells and stem cell models in disease & health (SCMiDH), Hasselt, Belgium, 2022.
Development of new computational models to evaluate age-related drugs cardiotoxicity Conferencia
XI Jornada de Jóvenes Investigadores del Instituto de Investigación en Ingeniería de Aragón (I3A), Zaragoza, Spain, 2022.
Development of new human models to determine age-related cardiotoxicity of drugs Conferencia
I ipIBA Day, Zaragoza, Spain, 2022.
Development of new human models to determine age-related cardiotoxicity of drugs Conferencia
Frontiers in CardioVascular Biomedicine (FCVB), Budapest, Hungría, 2022.
Human cardiac models for investigation of age-related cardiotoxic effects of drug compounds Conferencia
XV CIBER-BBN Annual Conference, Valencia, Spain, 2022.
Terapias cardiacas avanzadas con microRNAs basadas en nanoestructuras de DNA Conferencia
XI Jornada de Jóvenes Investigadores, Zaragoza, Spain, 2022.
Towards advanced cardiac miRNA therapies through DNA-based nanostructures Conferencia
Frontiers in CardioVascular Biomedicine (FCVB), Budapest, Hungría, 2022.
Terapias cardiacas avanzadas con microRNAs basadas en nanoestructuras de DNA Conferencia
I iPIBA Day, Zaragoza, Spain, 2022.
Improving Signal Stability in a Multi-Electrode Array (MEA) System for Cardiac Biopsies Conferencia
Proceedings of the 37th Conference on Design of Circuits and Integrated Systems, Pamplona, Spain, 2022.
XI Jornada de Jóvenes Investigadores e Investigadoras del I3A, 2022.
2021
Artículos de revista
Validity of the Polar H7 Heart Rate Sensor for Heart Rate Variability Analysis during Exercise in Different Age, Body Composition and Fitness Level Groups Artículo de revista
En: Sensors, vol. 21, no. 902, 2021.
QT variability unrelated to RR variability during stress testing for identification of coronary artery disease Artículo de revista
En: Phil. Trans. R. Soc. A., vol. 379: 20200261, 2021.
Periodic Repolarization Dynamics as Predictor of Risk for Sudden Cardiac Death in Chronic Heart Failure Patients Artículo de revista
En: Scientific Reports, vol. 11:20546, 2021.
Monitoring Blood Potassium Concentration in Hemodialysis Patients by Quantifying T-wave Morphology Dynamics Artículo de revista
En: Scientific reports, vol. 11, no. 3883, 2021.