Laura Ordovás Vidal
Faculty Member
Biography
Laura Ordovás was born in Zaragoza, Spain, in 1979. She received her M.Sc degree in Biochemistry in 2002 and the PhD degree in Genetics and Development in December 2006, both at the University of Zaragoza.
After a two-year post-doc in her PhD lab, in January 2009 and till mid-2014, she joined the Stem Cell Institute of the Katholiek Universiteit Leuven (KUL) for a post-doctoral period under the supervision of Prof. Verfiallie. She specialized in human pluripotent stem cell research and genome engineering using directed nucleases (ZFNs, TALENs and later CRISPR-Cas9). She worked in the creation of tools for lineage tracing during directed differentiation towards specific lineages and in in vitro modelling of human disease, among others.
In 2015, she joined BSICoS at the Aragon Institute of Engineering Research (I3A) of the University of Zaragoza as Senior Research Associate in the project MODELAGE lead by Esther Pueyo. In 2016 she was awarded an ARAID researcher position and since 2017, she is a faculty research member of the BSICoS group.
Her current research activities comprise the understanding of human cardiac aging and other cardiac conditions from in vitro modelling using iPSC and genome engineering and the integration of the experimental data in computational biology.
Publications
2022
Artículos de revista
Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons Artículo de revista
En: Animals, vol. 11, no. 1137, 2022.
Analysis of age-related left ventricular collagen remodeling in living donors: implications in arrhythmogenesis Artículo de revista
En: iScience, 2022.
Conferencias
XI Jornada de Jóvenes Investigadores del I3A, 2022.
Envejecimiento cardíaco humano: transcriptómica y desarrollo de modelos celulares Conferencia
II Congreso Anual de Estudiantes de Doctorado (CAED), Universidad Miguel Hernández, Elche, 2022.
Development of new human models to determine age related cardiotoxicity of drugs Conferencia
Stem cells and stem cell models in disease & health (SCMiDH), Hasselt, Belgium, 2022.
Development of new computational models to evaluate age-related drugs cardiotoxicity Conferencia
XI Jornada de Jóvenes Investigadores del Instituto de Investigación en Ingeniería de Aragón (I3A), Zaragoza, Spain, 2022.
Development of new human models to determine age-related cardiotoxicity of drugs Conferencia
I ipIBA Day, Zaragoza, Spain, 2022.
Development of new human models to determine age-related cardiotoxicity of drugs Conferencia
Frontiers in CardioVascular Biomedicine (FCVB), Budapest, Hungría, 2022.
Human cardiac models for investigation of age-related cardiotoxic effects of drug compounds Conferencia
XV CIBER-BBN Annual Conference, Valencia, Spain, 2022.
Terapias cardiacas avanzadas con microRNAs basadas en nanoestructuras de DNA Conferencia
XI Jornada de Jóvenes Investigadores, Zaragoza, Spain, 2022.
Towards advanced cardiac miRNA therapies through DNA-based nanostructures Conferencia
Frontiers in CardioVascular Biomedicine (FCVB), Budapest, Hungría, 2022.
Terapias cardiacas avanzadas con microRNAs basadas en nanoestructuras de DNA Conferencia
I iPIBA Day, Zaragoza, Spain, 2022.
MicroRNAs cardiacos en envejecimiento: Dianas terapéuticas y biomarcadores Conferencia
I iPIBA Day, Zaragoza, Spain, 2022.
Development of tailored DNA nanostructures for anticancer drug delivery Conferencia
XXXVIII Reunión Bienal RSEQ, Granada, España, 2022.
DNA nanostructures customized for therapeutic delivery Conferencia
5th Spanish Conference on Biomedical Applications of Nanomaterials SBAN, Madrid, Spain, 2022.
2021
Artículos de revista
Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution Artículo de revista
En: Aging Cell, vol. 00:e13383, pp. 1-16, 2021.
Conferencias
Envejecimiento cardiaco humano: transcriptómica y desarrollo de modelos celulares de envejecimiento Conferencia
X Jornada de Jóvenes Investigadores I3A. Comunicación oral, 2021.
In vivo and in vitro cardiac aging: developing of cellular aging models Conferencia
XIX Congreso de la Sociedad Española de Biología Celular. Póster, 2021.
Proceedings of the XLVII International Conference on Computing in Cardiology, Brno, Czech Republic, 2021.
Caracterización del remodelado cardiaco asociado a la edad en el ventrículo izquierdo humano Conferencia
Primer congreso anual de estudiantes de doctorado de la Universidad Miguel Hernández. Comunicación oral, 2021.
2020
Artículos de revista
Minimally invasive system to reliably characterize ventricular electrophysiology from living donors Artículo de revista
En: Sci Rep, vol. 10, no. 19941, 2020.
Automatic quantification of cardiomyocyte dimensions and connexin 43 lateralization in fluorescence images Artículo de revista
En: Biomolecules, vol. 10, no. 9, pp. 1334, 2020.
Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients Artículo de revista
En: Oxidative Medicine and Cellular Longevity, vol. ID 8895078, 2020.
Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines Artículo de revista
En: Nature Communications, 2020.
2019
Conferencias
Transcriptional analysis of human cardiac aging by chronological and biological age Conferencia
European Society of Cardiology (ESC), 2019.
The role of microRNAs in age-related remodeling of the human left ventricle Conferencia
European Society of Cardiology (ESC), vol. Poster, 2019.
Histological characterization of age-related remodeling in human left ventricle by second harmonic generation and lipofuscin content Conferencia
European Society of Cardiology (ESC), vol. Poster, 2019.
2018
Conferencias
Transcriptional analysis of human cardiac aging by chronological and biological age Conferencia
Aging and Metabolism, Cell Symposia, 2018.
Analysis of the role of microRNA in age-related heart electrophysiological remodeling Conferencia
Aging and Metabolism, Cell Symposia, 2018.
2017
Artículos de revista
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients Artículo de revista
En: Nat. Commun, vol. 8, no. 861, 2017.