Address

I3A: Universidad de Zaragoza – Instituto de Investigación en Ingeniería de Aragón (I3A). C/ Poeta Mariano Esquillor, s/n, Edif. I+D, Pl 1ª, Lab 5.1.01. 50018 Zaragoza
SAI: Calle de Pedro Cerbuna 12, Planta 2 – 50009 Zaragoza (Spain)

Contact Information

Call: I3A: +34 876 55 51 56; SAI: +34 876 55 43 32

Email: lordovas@unizar.es

Laura Ordovás Vidal

Faculty Member

Biography

Laura Ordovás was born in Zaragoza, Spain, in 1979. She received her M.Sc degree in Biochemistry in 2002 and the PhD degree in Genetics and Development in December 2006, both at the University of Zaragoza.

After a two-year post-doc in her PhD lab, in January 2009 and till mid-2014, she joined the Stem Cell Institute of the Katholiek Universiteit Leuven (KUL) for a post-doctoral period under the supervision of Prof. Verfiallie. She specialized in human pluripotent stem cell research and genome engineering using directed nucleases (ZFNs, TALENs and later CRISPR-Cas9). She worked in the creation of tools for lineage tracing during directed differentiation towards specific lineages and in in vitro modelling of human disease, among others.

In 2015, she joined BSICoS at the Aragon Institute of Engineering Research (I3A) of the University of Zaragoza as Senior Research Associate in the project MODELAGE lead by Esther Pueyo. In 2016 she was awarded an ARAID researcher position and since 2017, she is a faculty research member of the BSICoS group.

Her current research activities comprise the understanding of human cardiac aging and other cardiac conditions from in vitro modelling using iPSC and genome engineering and the integration of the experimental data in computational biology.

Publications

2022

Artículos de revista

García-Mendívil, L; Pérez-Zabalza, M; Mountris, K; Duwé, S; Smisdom, N; Pérez, M; Luján, L; Wolfs, E; Driesen, R B; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Vázquez-Sancho, M; Matamala-Adell, M; Sorribas-Berjón, J F; Bellido-Morales, J A; Mancebón-Sierra, F J; Vaca-Núñez, A S; Ballester-Cuenca, C; Oliván-Viguera, A; Diez, E; Ordovás, L; Pueyo, E

Analysis of age-related left ventricular collagen remodeling in living donors: implications in arrhythmogenesis Artículo de revista

En: iScience, 2022.

Enlaces | BibTeX

García-Mendívil, L; Mediano, D; Hernaiz, A; Sanz, D; Vázquez, F; Marín, B; López, O; Otero, A; Badiola, J; Zaragoza, P; Ordovás, L; Bolea, R; Martín, I

Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons Artículo de revista

En: Animals, 11 (1137), 2022.

Enlaces | BibTeX

2021

Artículos de revista

Ramos-Marquès, E; García-Mendívil, L; Pérez-Zabalza, M; Santander-Badules, H; Srinivasan, S; Oliveros, J C; Torres-Pérez, R; Cebollada, A; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Vázquez-Sancho, M; Matamala-Adell, M; Sorribas-Berjón, J F; Bellido-Morales, J A; Mancebón-Sierra, F J; Vaca-Núñez, A S; Ballester-Cuenca, C; Jiménez-Navarro, M; Villaescusa, J M; Garrido-Huéscar, E; Segovia-Roldán, M; Oliván-Viguera, A; Gómez-González, C; Muñiz, G; Diez, E; Ordovás, L; Pueyo, E

Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution Artículo de revista

En: Aging Cell, 00:e13383 , pp. 1-16, 2021.

Enlaces | BibTeX

Conferencias

Smisdom, N; Duwe, S; Mountris, K; Srinivasan, S; Pérez, M; Luján, L; Wolfs, E; Driesen, R B; Olivan-Viguera, A; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Vázquez-Sancho, M; Matamala-Adell, M; Sorribas-Berjón, F; Ballester-Cuenca, C; Diez, E; Ordovás, L; Pueyo, E

Caracterización del remodelado cardiaco asociado a la edad en el ventrículo izquierdo humano Conferencia

Primer congreso anual de estudiantes de doctorado de la Universidad Miguel Hernández. Comunicación oral, 2021.

BibTeX

García-Mendívil, L; Hernández, N; Sánchez, M; Pérez-Zabalza, M; Garrido-Huéscar, E; Oliveros, J C; Torres, R; Ramos, E; Pueyo, E; Ordovás, L

Envejecimiento cardiaco humano: transcriptómica y desarrollo de modelos celulares de envejecimiento Conferencia

X Jornada de Jóvenes Investigadores I3A. Comunicación oral, 2021.

Enlaces | BibTeX

García-Mendívil, L; Hernández, N; Sánchez, M; Pérez-Zabalza, M; Garrido-Huéscar, E; Oliveros, J C; Torres, R; Ramos, E; Pueyo, E; Ordovás, L

In vivo and in vitro cardiac aging: developing of cellular aging models Conferencia

XIX Congreso de la Sociedad Española de Biología Celular. Póster, 2021.

BibTeX

Pérez, M; García-Mendívil, L; Mountris, K; Smisdom, N; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Matamala-Adell, M; Vázquez-Sancho, M; Mancebón-Sierra, F Javier; Vaca-Núñez, A Sebastián; Ballester-Cuenca, C; Olivan-Viguera, A; Ordovás, L; Pueyo, E

Age-associated changes in fibrosis amount and spatial organization and its effects on human ventricular electrophysiology Conferencia

Proceedings of the XLVII International Conference on Computing in Cardiology, Brno, Czech Republic, 2021.

BibTeX

2020

Artículos de revista

Boon, R; Kumar, M; Tricot, T; Elia, I; Ordovas, L; Jacobs, F; One, J; Smedt, J De; Eelen, G; Bird, M; Roelandt, P; Doglioni, G; Vriens, K; Rossi, M; Vazquez, M A; Vanwelden, T; Chesnais, F; Taghdouini, A El; Najimi, M; Sokal, E; Cassiman, D; Snoeys, J; Monshouwer, M; Hu, W S; Lange, C; Carmeliet, P; Fendt, S M; Verfaillie, C M

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines Artículo de revista

En: Nature Communications, 2020.

Enlaces | BibTeX

Oliván‑Viguera, A; Pérez‑Zabalza, M; García‑Mendívil, L; Mountris, K A; Orós‑Rodrigo, S; Ramos‑Marquès, E; Vallejo‑Gil, J M; Fresneda‑Roldán, P C; Fañanás‑Mastral, J; Vázquez‑Sancho, M; Matamala‑Adell, M; Sorribas‑Berjón, F; Bellido‑Morales, J A; Mancebón‑Sierra, F J; Vaca‑Núñez, A S; Ballester‑Cuenca, C; Marigil, M A; Pastor, C; Ordovás, L; Köhler, R; Diez, E; Pueyo, E

Minimally invasive system to reliably characterize ventricular electrophysiology from living donors Artículo de revista

En: Sci Rep, 10 (19941), 2020.

Enlaces | BibTeX

Oliver-Gelabert, A; García-Mendívil, L; Vallejo-Gil, J M; Fresneda-Roldán, P C; Andelová, K; Fañanás-Mastral, J; Vázquez-Sancho, M; Matamala-Adell, M; Sorribas-Berjón, F; Ballester-Cuenca, C; Tribulova, N; Ordovás, L; Diez, E R; Pueyo, E

Automatic quantification of cardiomyocyte dimensions and connexin 43 lateralization in fluorescence images Artículo de revista

En: Biomolecules, 10 (9), pp. 1334, 2020.

Enlaces | BibTeX

Sánchez, F J; Gonzalez, V A; Farrando, M; Jayat, A O Baigorria; Segovia-Roldan, M; García-Mendívil, L; Ordovás, L; Prado, N J; Pueyo, E; Diez, E R

Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients Artículo de revista

En: Oxidative Medicine and Cellular Longevity, ID 8895078 , 2020.

Enlaces | BibTeX

2019

Conferencias

Ramos, E; García, L; Oliveros, J C; Torres, R; López, A; Oliván, A; Vallejo, J M; Fresneda, P C; Fañanás, J; Matamala, M; Sorribas, F; Vázquez, M; Ballester, C; Ordovás, L; Pueyo, E

The role of microRNAs in age-related remodeling of the human left ventricle Conferencia

European Society of Cardiology (ESC), Poster , 2019.

BibTeX

García, L; Smisdom, N; Mountris, K A; Oliván, A; Vallejo, J M; Fresneda, P C; Fañanás, J; Matamala, M; Sorribas, F; Vázquez, M; Ballester, C; Wolfs, E; Driesen, R B; Ordovás, L; Pueyo, E

Histological characterization of age-related remodeling in human left ventricle by second harmonic generation and lipofuscin content Conferencia

European Society of Cardiology (ESC), Poster , 2019.

BibTeX

García, L; Ramos, E; Oliveros, J C; Torres, R; Pueyo, E; Ordovás, L

Transcriptional analysis of human cardiac aging by chronological and biological age Conferencia

European Society of Cardiology (ESC), 2019.

BibTeX

2018

Conferencias

Ramos-Marqués, E; García-Mendívil, L; Oliveros, J C; Torres-Pérez, R; Oliván, A; Ordovás, L; Pueyo, E

Analysis of the role of microRNA in age-related heart electrophysiological remodeling Conferencia

Aging and Metabolism, Cell Symposia, 2018.

Enlaces | BibTeX

García-Mendívil, L; Ramos-Marqués, E; Oliveros, J C; Torres-Pérez, R; Fernández-Bes, J; Oliván, A; Pueyo, E; Ordovás, L

Transcriptional analysis of human cardiac aging by chronological and biological age Conferencia

Aging and Metabolism, Cell Symposia, 2018.

Enlaces | BibTeX

2017

Artículos de revista

Guo, W; Naujock, M; Fumagalli, L; Vandoorne, T; Baatsen, P; Boon, R; Ordovás, L; Patel, A; Welters, M; and, T Tricot

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients Artículo de revista

En: Nat. Commun, 8 (861), 2017.

Enlaces | BibTeX

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