Faculty Member

Call:
I3A: +34 876 55 51 56
SAI: +34 876 55 43 32

Email: lordovas@unizar.es

Address:
I3A: Universidad de Zaragoza – Instituto de Investigación en Ingeniería de Aragón (I3A). C/ Poeta Mariano Esquillor, s/n, Edif. I+D, Pl 1ª, Lab 5.1.01. 50018 Zaragoza
SAI: Calle de Pedro Cerbuna 12, Planta 2 – 50009 Zaragoza (Spain) (Spain)

ABOUT ME

Laura Ordovás was born in Zaragoza, Spain, in 1979. She received her M.Sc degree in Biochemistry in 2002 and the PhD degree in Genetics and Development in December 2006, both at the University of Zaragoza.

After a two-year post-doc in her PhD lab, in January 2009 and till mid-2014, she joined the Stem Cell Institute of the Katholiek Universiteit Leuven (KUL) for a post-doctoral period under the supervision of Prof. Verfiallie. She specialized in human pluripotent stem cell research and genome engineering using directed nucleases (ZFNs, TALENs and later CRISPR-Cas9). She worked in the creation of tools for lineage tracing during directed differentiation towards specific lineages and in in vitro modelling of human disease, among others.

In 2015, she joined BSICoS at the Aragon Institute of Engineering Research (I3A) of the University of Zaragoza as Senior Research Associate in the project MODELAGE lead by Esther Pueyo. In 2016 she was awarded an ARAID researcher position and since 2017, she is a faculty research member of the BSICoS group.

Her current research activities comprise the understanding of human cardiac aging and other cardiac conditions from in vitro modelling using iPSC and genome engineering and the integration of the experimental data in computational biology.

PUBLICATIONS
71 entries « 1 of 3 »

2025

Journal Articles

Hernández‑Bellido, N; Hernández‑Vicente, A; García‑Mendívil, L; Ramos‑Marquès, E; Hernando, D; Cebollada, A; Köhler, R; Garatachea, N; Pueyo, E; Ordovás, L

A simple blood biomarker based on gene expression describes cardiovascular health‑related biological age Journal Article

In: GeroScience, 2025.

Links | BibTeX

Conferences

Gómez, C; Paz, L; Santander, H; Ordovás, L; Ciriza, J

Building a Heart-on-Chip: First Steps Towards a Vascularized Cardiac In Vitro Model Conference

Jornadas de Jóvenes Investigadores del I3A, vol. 13, 2025, ISSN: ISSN 2341-4790.

Links | BibTeX

Usón, S; Asensio, C; Ruíz, J J; Candeal, E; Ranera, B; Ramírez, J; Ordovás, L

Análisis Bioinformático del Genoma Oscuro Transcrito para el Descubrimiento de Dianas en Fibrilación Auricular Conference

Jornadas de Jóvenes Investigadores del I3A, vol. 13, 2025, ISSN: 2341-4790.

BibTeX

Gómez-Moreno, C; Paz-Artigas, L; Santander-Badules, H; Ordovás, L; Ciriza, J

Hacia un modelo corazón-en-chip vascularizado: primeros pasos para una barrera endotelial funcional Conference

Proceedings CASEIB 2025, Zaragoza, 2025.

Links | BibTeX

Ripalda-Paredes, M; Sánchez-Barat, M; Porosk, L; Ordovás, L; Pooga, M; Hernández-Ainsa, S

Functional screening of cell-penetrating peptides to enhance the delivery of RNAi-loaded nucleic acid nanostructures Conference

28th Wilhelm Bernhard Workshops on the Cell Nucleus conference, Tartu, Estonia, 2025.

Links | BibTeX

Gómez-Moreno, C; Paz-Artigas, L; Santander-Badules, H; Ordovás, L; Ciriza, J

Towards a human endothelialised heart-on-a-chip to model cardiac pathophysiology Conference

IV ipIBA Day 2025, Zaragoza, 2025.

Links | BibTeX

Ripalda-Paredes, M; Sánchez-Barat, M; Porosk, L; Ordovás, L; Pooga, M; Hernández-Ainsa, S

Improving internalization of DNA origami and tetrahedron via cell penetrating peptides (CPPs) complexation for future RNA therapeutic delivery Conference

7th Functional DNA Nanotechnology Workshop, Rome, Italy, 2025.

Links | BibTeX

Ordovás, L; Hernández-Bellido, N; Postigo, A; Sánchez-Barat, M; Ripalda-Paredes, M; Usón, S; Ruíz-Araca, J J; Candeal, E; Ramírez, J; Ranera, B; Gorospe, M; del Barrio, J; Hernández-Ainsa, S

miR-24-2 modulation in cardiac dysfunction through DNA nanotechnology Conference

NanoBio&Med, Barcelona, Spain, 2025.

Links | BibTeX

Ripalda-Paredes, M; Sánchez-Barat, M; Poros, L; Ordovás, L; Pooga, M; Hernández-Ainsa, S

CPPs tailored DNA nanocarriers as a platform towards RNAi cardiotherapeutics Conference

NanoBio&Med2025, Barcelona, Spain, 2025.

Links | BibTeX

Sánchez-Barata, M; Hernández-Bellido, N; Postigo, A; Ripalda-Paredes, M; Hernández-Ainsa, S; Ordovas, L

DNA Nanoparticles for Cardiac Regeneration with miR-199a-3p Conference

NanoBio&Med2025, Barcelona, Spain, 2025.

Links | BibTeX

Hernández-Ainsa, S; Postigo, A; Sánchez-Barat, M; Ripalda-Paredes, M; Sarasa, S; Baumann, K N; Verstraeten, W; Göpfrich, K; Ordovás, L; del Barrio, J

Engineering DNA nanostructures for therapeutic delivery and biomimetic applications Conference

NanoBio&Med2025, Barcelona, Spain, 2025.

Links | BibTeX

Stankiewicz, S; Hinz, A; Ripalda, M; Sánchez-Barat, M; Postigo, A; Ordovás, L; Hernández-Ainsa, S; Bzowska, S

Building Safe Therapeutic Carriers from DNA: A Comprehensive Evaluation of DNA Nanostructure Biocompatibility Conference

NanoBio&Med2025, Barcelona, Spain, 2025.

Links | BibTeX

2024

Journal Articles

Postigo, A; Hernández-Bellido, N; Sánchez-Barat, M; García-Mendívil, L; Pueyo, E; del Barrio, J; Hernández-Ainsa, S; Ordovás, L

DNA-Based Nanocarriers to Sequester Altered microRNAs in Cardiac Dysfunction Journal Article

In: Adv. Therap., no. 2400247, 2024.

Links | BibTeX

Bueno, J M; Martínez-Ojeda, R M; Pérez-Zabalza, M; García-Mendívil, L; Asensio, M C; Ordovás, L; Pueyo, E

Analysis of age-related changes in the left ventricular myocardium with multiphoton microscopy Journal Article

In: Biomedical Optics Express, vol. 15, iss. 5, pp. 3251-3264, 2024.

Links | BibTeX

Conferences

Paz-Artigas, I; Gómez-Moreno, C; García-Mendivil, L; Sánchez-Barat, M; Ordovás, L; Ciriza, J

Functional endothelial barrier recreation in a heart-on-chip platform for cardio-directed therapies testing Conference

EUROOCS, Milan (Italy), 2024.

BibTeX

Paz-Artigas, I; Gómez-Moreno, C; García-Mendivil, L; Sánchez-Barat, M; Ordovás, L; Ciriza, J

Functional endothelial barrier recreation in a heart-on-chip platform for cardio-directed therapies testing Conference

IEUROOCS, Milan, Italy, 2024.

BibTeX

Sánchez-Barat, M; Hernández-Bellido, N; Postigo, A; Ripalda-Paredes, M; Hernández-Ainsa, S; Ordovás, L

Desarrollo de nanotransportadores de DNA de vanguardia con capacidad cardioregenerativa utilizando el potencial terapéutico de los microRNAs Conference

Jornadas de Jóvenes Investigadores del I3A, vol. 12, 2024.

Links | BibTeX

Gómez-Moreno, C; Hernández-Bellido, N; García-Mendívil, L; Sánchez-Barat, M; Paz-Artigas, L; Ciriza, J; Ordovás, L

Exploring shRNA-based therapy to prevent chemotherapy-induced cardiotoxicity Conference

Jornadas de Jóvenes Investigadores del I3A, vol. 12, 2024.

Links | BibTeX

2023

Journal Articles

García-Mendívil, L; Pérez-Zabalza, M; Oliver-Gelabert, A; Vallejo-Gil, J M; Fañanás-Mastral, J; Vázquez-Sancho, M; André-Bellido, J A; Vaca-Núñez, A S; Ballester-Cuenca, C; Diez, E R; Ordovás, L; Pueyo, E

Interindividual age-independent differences in human CX43 impact ventricular arrhythmic risk Journal Article

In: Research, vol. 6, iss. 0254, 2023.

Links | BibTeX

García-Mendívil, L; Pérez-Zabalza, M; Duwé, S; Ordovás, L; Pueyo, E

Automatic quantification of myocardial remodeling features in human ventricular tissue from label-free microscopy Journal Article

In: Star Protocols, vol. 4, no. 102730, 2023.

Links | BibTeX

Conferences

Garrido-Huéscar, E; Vandeweyer, L; García-Mendivil, L; Hernández-Bellido, N; Pueyo, E; de Vos, W H; Ordovás, L

Cardiomiocitos derivados de células pluripotentes inducidas (hiPSC-CM) con progerina inducible para estudiar envejecimiento cardiaco Conference

XII Jornada de Jóvenes Investigadores e Investigadoras del I3A. Zaragoza, España "Vol. 11 (2023): Actas de la XII Jornada de Jóvenes Investigadores e Investigadoras del I3A, 2023.

Links | BibTeX

Hernández-Bellido, N; Ramos-Marquès, E; Hernández-Vicente, A; García-Mendivil, L; Santander-Badules, H; Mercanti, G; Garrido-Huéscar, E; Garatachea, N; Köhler, R; Pueyo, E; Ordovás, L

microRNAs en envejecimiento cardiaco humano: dianas terapéuticas y biomarcadores Conference

XII Jornada de Jóvenes Investigadores e Investigadoras del I3A. Zaragoza, España "Vol. 11 (2023): Actas de la XII Jornada de Jóvenes Investigadores e Investigadoras del I3A, 2023.

Links | BibTeX

García-Mendívil, L; Pérez, M; Rosales, R; Vallejo-Gil, J M; Fañanás-Mastral, J; Vázquez-Sancho, M; Bellido‑Morales, J A; Vaca‑Núñez, A S; Ballester-Cuenca, C; Ordovás, L; Pueyo, E

Physiological Variations in CX43 and Fibrosis Deposition Affect Human Ventricular Electrophysiology Promoting Arrhythmia Conference

Proceedings of the XLIX International Conference on Computing in Cardiology, Atlanta, USA, 2023.

Links | BibTeX

Bueno, J M; Martínez-Ojeda, R M; Asensio, M C; García-Mendívil, L; Pérez-Zabalza, M; Ordovás, L; Pueyo, E

Age-related Changes in Tissue Structure of the Heart Left Ventricle Assessed with Multiphoton Microscopy Conference

Optica Biophotonics Congress: Optics in the Life Sciences, Vancouver (Canada), 2023.

BibTeX

Hernández-Bellido, N; Ramos-Marquès, E; Hernández-Vicente, A; García-Mendívil, L; Santanter-Badules, H; Mercanti, G; Garrido-Huéscar, E; Garatachea, N; Kohler, R; Pueyo, E; Ordovás, L

microRNAs in human cardiac aging: therapeutic targets and biomarkers Conference

I Congreso de Estudiantes de Doctorado Iberus Connect (CEDIC), Zaragoza (Spain), 2023.

BibTeX

Vandeweyer, L; Molenbergh, F; Garrido-Huéscar, E; Loeys, B; Ordovás, L; Vos, W H De

Lamin-mediated chromatin condensation in dilated cardiomyopathy Conference

4th International Meeting on Laminopathies, Madrid (Spain), 2023.

BibTeX

Garrido-Huéscar, E; Vandeweyer, L; García-Mendívil, L; Hernández-Bellido, N; Pueyo, E; Vos, W H De; Ordovás, L

A progerin-inducible human Induced Pluripotent Stem Cell line to study cardiac cell aging Conference

4th International Meeting on Laminopathies, Madrid (Spain), 2023.

BibTeX

González-Lana, S; Oliván-Viguera, A; Rosales, R M; Remacha, A R; Ordovás, L; Pueyo, E; Monge, R; Sánchez-Somolinos, C; Ciriza, J; Ochoa, I

Structural and functional impact of co-culturing iPSC-CM and HCAEC within microfluidic devices exposed to mechanical and electrical stimuli Conference

European organ-on-chip society Annual Meeting, Berlin (Alemania), 2023.

BibTeX

Hernández-Bellido, N; Postigo, A; Orrite, C; Garrido-Huéscar, E; García-Mendívil, L; Pueyo, E; Hernández-Ainsa, S; Ordovás, L

Non-viral delivery of microRNA therapies for cardiac dysfunction using DNA nanostructures Conference

12º Congreso bianual de la Sociedad Española de Terapia Génica y Celular (SETGyC), Pamplona (Sapin), 2023.

BibTeX

Sánchez-Barat, M; Hernández-Bellido, N; Postigo, A; Ordovás, L; Hernández-Ainsa, S

Towards post-ischemic cardiac regeneration with microRNA therapy and customized DNA-based nanostructures Conference

12º Congreso bianual de la Sociedad Española de Terapia Génica y Celular (SETGyC), Pamplona (Sapin), 2023.

BibTeX

71 entries « 1 of 3 »