Faculty Member

Call: +34 876 55 43 32

Email: lordovas@unizar.es

Address:
I3A: Universidad de Zaragoza – Instituto de Investigación en Ingeniería de Aragón (I3A). C/ Poeta Mariano Esquillor, s/n, Edif. I+D, Pl 1ª, Lab 5.1.01. 50018 Zaragoza
SAI: Calle de Pedro Cerbuna 12, Planta 2 – 50009 Zaragoza (Spain) (Spain)

ABOUT ME

I received my MSc degree in Biochemistry in 2002 and my PhD degree in Animal Genetics in December 2006, both from the University of Zaragoza (UNIZAR). I then completed a two-year postdoctoral period at UNIZAR, investigating the use of equine mesenchymal stem cells for cell therapy, after which I continued my training in stem cells for almost 6 years at the Stem Cell Institute of the Katholike Universiteit Leuven (KUL) in Belgium. There, I specialized in human pluripotent stem cell biology and genome engineering (ZFNs, TALENs and CRISPR-Cas9), with applications in human in vitro modelling for various biomedical purposes. 

In 2015, I joined the BSICoS group at the Aragon Institute of Engineering Research (I3A) of UNIZAR, and have been a faculty research member of the group as an ARAID researcher since 2017.   

My current research interests include the molecular and functional characterization of cardiac processes (aging and disease), the integration of the experimental data in computational biology, and the development of advanced therapies. This research aims to expand the range of therapeutic options for cardiac diseases with unmet medical needs through a molecular approach, with a focus on non-coding RNA, as well as to increase drug safety in relation to cardiotoxicity. Specific objectives:

– understanding the role of non-coding RNA in cardiac diseases through bioinformatics.

– developing advanced therapies for conditions such as chemotherapy-induced cardiotoxicity, myocardial infarction, cardiac fibrosis, or atrial fibrillation.

– developing human biomimetic models with high translational potential for evaluating these therapies.

Led projects include DIANA, ADVANCE, DNABEATS, DARKNAF and HITFIB.

PUBLICATIONS
74 registros « 1 de 3 »

2026

Artículos de revista

Hernández-Bellido, N; Hernández-Ainsa, S; Köhler, R; Ordovás, L

Nanotechnology-driven heart targeting to fulfil the potential of cardiac microRNA therapies Artículo de revista

En: International Journal of Pharmaceutics, vol. 692, no 126643, 2026.

Enlaces | BibTeX

Conferencias

Gómez, C; Fernández-Carro, E; Sharko, V; Remacha, A Rosa; Alcaine, C; García-Otín, Á L; Ordovás, L; Ciriza, J

Exploring oligonucleotide-based silencing strategies to prevent anthracycline-induced cardiotoxicity Conferencia

Jornadas de Jóvenes Investigadores del I3A, vol. 14, Zaragoza, 2026, ISSN: 2341-4790.

Enlaces | BibTeX

Fernández-Carro, E; Gómez-Moreno, C; Remacha, A R; Ordovás, L; Solanas, E; Ciriza, J

Toward engineering the human skin ecosystem: integrating skin microbiota, sweat, and organ-on-chip technology Conferencia

Jornadas de Jóvenes Investigadores del I3A, vol. 14, Zaragoza, 2026, ISSN: 2341-4790.

Enlaces | BibTeX

2025

Artículos de revista

Hernández‑Bellido, N; Hernández‑Vicente, A; García‑Mendívil, L; Ramos‑Marquès, E; Hernando, D; Cebollada, A; Köhler, R; Garatachea, N; Pueyo, E; Ordovás, L

A simple blood biomarker based on gene expression describes cardiovascular health‑related biological age Artículo de revista

En: GeroScience, 2025.

Enlaces | BibTeX

Conferencias

Gómez, C; Paz, L; Santander, H; Ordovás, L; Ciriza, J

Building a Heart-on-Chip: First Steps Towards a Vascularized Cardiac In Vitro Model Conferencia

Jornadas de Jóvenes Investigadores del I3A, vol. 13, 2025, ISSN: ISSN 2341-4790.

Enlaces | BibTeX

Usón, S; Asensio, C; Ruíz, J J; Candeal, E; Ranera, B; Ramírez, J; Ordovás, L

Análisis Bioinformático del Genoma Oscuro Transcrito para el Descubrimiento de Dianas en Fibrilación Auricular Conferencia

Jornadas de Jóvenes Investigadores del I3A, vol. 13, 2025, ISSN: 2341-4790.

BibTeX

Gómez-Moreno, C; Paz-Artigas, L; Santander-Badules, H; Ordovás, L; Ciriza, J

Hacia un modelo corazón-en-chip vascularizado: primeros pasos para una barrera endotelial funcional Conferencia

Proceedings CASEIB 2025, Zaragoza, 2025.

Enlaces | BibTeX

Ripalda-Paredes, M; Sánchez-Barat, M; Porosk, L; Ordovás, L; Pooga, M; Hernández-Ainsa, S

Functional screening of cell-penetrating peptides to enhance the delivery of RNAi-loaded nucleic acid nanostructures Conferencia

28th Wilhelm Bernhard Workshops on the Cell Nucleus conference, Tartu, Estonia, 2025.

Enlaces | BibTeX

Gómez-Moreno, C; Paz-Artigas, L; Santander-Badules, H; Ordovás, L; Ciriza, J

Towards a human endothelialised heart-on-a-chip to model cardiac pathophysiology Conferencia

IV ipIBA Day 2025, Zaragoza, 2025.

Enlaces | BibTeX

Ripalda-Paredes, M; Sánchez-Barat, M; Porosk, L; Ordovás, L; Pooga, M; Hernández-Ainsa, S

Improving internalization of DNA origami and tetrahedron via cell penetrating peptides (CPPs) complexation for future RNA therapeutic delivery Conferencia

7th Functional DNA Nanotechnology Workshop, Rome, Italy, 2025.

Enlaces | BibTeX

Ordovás, L; Hernández-Bellido, N; Postigo, A; Sánchez-Barat, M; Ripalda-Paredes, M; Usón, S; Ruíz-Araca, J J; Candeal, E; Ramírez, J; Ranera, B; Gorospe, M; del Barrio, J; Hernández-Ainsa, S

miR-24-2 modulation in cardiac dysfunction through DNA nanotechnology Conferencia

NanoBio&Med, Barcelona, Spain, 2025.

Enlaces | BibTeX

Ripalda-Paredes, M; Sánchez-Barat, M; Poros, L; Ordovás, L; Pooga, M; Hernández-Ainsa, S

CPPs tailored DNA nanocarriers as a platform towards RNAi cardiotherapeutics Conferencia

NanoBio&Med2025, Barcelona, Spain, 2025.

Enlaces | BibTeX

Sánchez-Barata, M; Hernández-Bellido, N; Postigo, A; Ripalda-Paredes, M; Hernández-Ainsa, S; Ordovas, L

DNA Nanoparticles for Cardiac Regeneration with miR-199a-3p Conferencia

NanoBio&Med2025, Barcelona, Spain, 2025.

Enlaces | BibTeX

Hernández-Ainsa, S; Postigo, A; Sánchez-Barat, M; Ripalda-Paredes, M; Sarasa, S; Baumann, K N; Verstraeten, W; Göpfrich, K; Ordovás, L; del Barrio, J

Engineering DNA nanostructures for therapeutic delivery and biomimetic applications Conferencia

NanoBio&Med2025, Barcelona, Spain, 2025.

Enlaces | BibTeX

Stankiewicz, S; Hinz, A; Ripalda, M; Sánchez-Barat, M; Postigo, A; Ordovás, L; Hernández-Ainsa, S; Bzowska, S

Building Safe Therapeutic Carriers from DNA: A Comprehensive Evaluation of DNA Nanostructure Biocompatibility Conferencia

NanoBio&Med2025, Barcelona, Spain, 2025.

Enlaces | BibTeX

2024

Artículos de revista

Postigo, A; Hernández-Bellido, N; Sánchez-Barat, M; García-Mendívil, L; Pueyo, E; del Barrio, J; Hernández-Ainsa, S; Ordovás, L

DNA-Based Nanocarriers to Sequester Altered microRNAs in Cardiac Dysfunction Artículo de revista

En: Adv. Therap., no 2400247, 2024.

Enlaces | BibTeX

Bueno, J M; Martínez-Ojeda, R M; Pérez-Zabalza, M; García-Mendívil, L; Asensio, M C; Ordovás, L; Pueyo, E

Analysis of age-related changes in the left ventricular myocardium with multiphoton microscopy Artículo de revista

En: Biomedical Optics Express, vol. 15, iss. 5, pp. 3251-3264, 2024.

Enlaces | BibTeX

Conferencias

Paz-Artigas, I; Gómez-Moreno, C; García-Mendivil, L; Sánchez-Barat, M; Ordovás, L; Ciriza, J

Functional endothelial barrier recreation in a heart-on-chip platform for cardio-directed therapies testing Conferencia

EUROOCS, Milan (Italy), 2024.

BibTeX

Paz-Artigas, I; Gómez-Moreno, C; García-Mendivil, L; Sánchez-Barat, M; Ordovás, L; Ciriza, J

Functional endothelial barrier recreation in a heart-on-chip platform for cardio-directed therapies testing Conferencia

IEUROOCS, Milan, Italy, 2024.

BibTeX

Sánchez-Barat, M; Hernández-Bellido, N; Postigo, A; Ripalda-Paredes, M; Hernández-Ainsa, S; Ordovás, L

Desarrollo de nanotransportadores de DNA de vanguardia con capacidad cardioregenerativa utilizando el potencial terapéutico de los microRNAs Conferencia

Jornadas de Jóvenes Investigadores del I3A, vol. 12, 2024.

Enlaces | BibTeX

Gómez-Moreno, C; Hernández-Bellido, N; García-Mendívil, L; Sánchez-Barat, M; Paz-Artigas, L; Ciriza, J; Ordovás, L

Exploring shRNA-based therapy to prevent chemotherapy-induced cardiotoxicity Conferencia

Jornadas de Jóvenes Investigadores del I3A, vol. 12, 2024.

Enlaces | BibTeX

2023

Artículos de revista

García-Mendívil, L; Pérez-Zabalza, M; Duwé, S; Ordovás, L; Pueyo, E

Automatic quantification of myocardial remodeling features in human ventricular tissue from label-free microscopy Artículo de revista

En: Star Protocols, vol. 4, no 102730, 2023.

Enlaces | BibTeX

García-Mendívil, L; Pérez-Zabalza, M; Oliver-Gelabert, A; Vallejo-Gil, J M; Fañanás-Mastral, J; Vázquez-Sancho, M; André-Bellido, J A; Vaca-Núñez, A S; Ballester-Cuenca, C; Diez, E R; Ordovás, L; Pueyo, E

Interindividual age-independent differences in human CX43 impact ventricular arrhythmic risk Artículo de revista

En: Research, vol. 6, iss. 0254, 2023.

Enlaces | BibTeX

Conferencias

Garrido-Huéscar, E; Vandeweyer, L; García-Mendivil, L; Hernández-Bellido, N; Pueyo, E; de Vos, W H; Ordovás, L

Cardiomiocitos derivados de células pluripotentes inducidas (hiPSC-CM) con progerina inducible para estudiar envejecimiento cardiaco Conferencia

XII Jornada de Jóvenes Investigadores e Investigadoras del I3A. Zaragoza, España "Vol. 11 (2023): Actas de la XII Jornada de Jóvenes Investigadores e Investigadoras del I3A, 2023.

Enlaces | BibTeX

Hernández-Bellido, N; Ramos-Marquès, E; Hernández-Vicente, A; García-Mendivil, L; Santander-Badules, H; Mercanti, G; Garrido-Huéscar, E; Garatachea, N; Köhler, R; Pueyo, E; Ordovás, L

microRNAs en envejecimiento cardiaco humano: dianas terapéuticas y biomarcadores Conferencia

XII Jornada de Jóvenes Investigadores e Investigadoras del I3A. Zaragoza, España "Vol. 11 (2023): Actas de la XII Jornada de Jóvenes Investigadores e Investigadoras del I3A, 2023.

Enlaces | BibTeX

Bueno, J M; Martínez-Ojeda, R M; Asensio, M C; García-Mendívil, L; Pérez-Zabalza, M; Ordovás, L; Pueyo, E

Age-related Changes in Tissue Structure of the Heart Left Ventricle Assessed with Multiphoton Microscopy Conferencia

Optica Biophotonics Congress: Optics in the Life Sciences, Vancouver (Canada), 2023.

BibTeX

Hernández-Bellido, N; Ramos-Marquès, E; Hernández-Vicente, A; García-Mendívil, L; Santanter-Badules, H; Mercanti, G; Garrido-Huéscar, E; Garatachea, N; Kohler, R; Pueyo, E; Ordovás, L

microRNAs in human cardiac aging: therapeutic targets and biomarkers Conferencia

I Congreso de Estudiantes de Doctorado Iberus Connect (CEDIC), Zaragoza (Spain), 2023.

BibTeX

Vandeweyer, L; Molenbergh, F; Garrido-Huéscar, E; Loeys, B; Ordovás, L; Vos, W H De

Lamin-mediated chromatin condensation in dilated cardiomyopathy Conferencia

4th International Meeting on Laminopathies, Madrid (Spain), 2023.

BibTeX

Garrido-Huéscar, E; Vandeweyer, L; García-Mendívil, L; Hernández-Bellido, N; Pueyo, E; Vos, W H De; Ordovás, L

A progerin-inducible human Induced Pluripotent Stem Cell line to study cardiac cell aging Conferencia

4th International Meeting on Laminopathies, Madrid (Spain), 2023.

BibTeX

González-Lana, S; Oliván-Viguera, A; Rosales, R M; Remacha, A R; Ordovás, L; Pueyo, E; Monge, R; Sánchez-Somolinos, C; Ciriza, J; Ochoa, I

Structural and functional impact of co-culturing iPSC-CM and HCAEC within microfluidic devices exposed to mechanical and electrical stimuli Conferencia

European organ-on-chip society Annual Meeting, Berlin (Alemania), 2023.

BibTeX

74 registros « 1 de 3 »