Faculty Member

Call:
I3A: +34 876 55 51 56
SAI: +34 876 55 43 32

Email: lordovas@unizar.es

Address:
I3A: Universidad de Zaragoza – Instituto de Investigación en Ingeniería de Aragón (I3A). C/ Poeta Mariano Esquillor, s/n, Edif. I+D, Pl 1ª, Lab 5.1.01. 50018 Zaragoza
SAI: Calle de Pedro Cerbuna 12, Planta 2 – 50009 Zaragoza (Spain) (Spain)

ABOUT ME

Laura Ordovás was born in Zaragoza, Spain, in 1979. She received her M.Sc degree in Biochemistry in 2002 and the PhD degree in Genetics and Development in December 2006, both at the University of Zaragoza.

After a two-year post-doc in her PhD lab, in January 2009 and till mid-2014, she joined the Stem Cell Institute of the Katholiek Universiteit Leuven (KUL) for a post-doctoral period under the supervision of Prof. Verfiallie. She specialized in human pluripotent stem cell research and genome engineering using directed nucleases (ZFNs, TALENs and later CRISPR-Cas9). She worked in the creation of tools for lineage tracing during directed differentiation towards specific lineages and in in vitro modelling of human disease, among others.

In 2015, she joined BSICoS at the Aragon Institute of Engineering Research (I3A) of the University of Zaragoza as Senior Research Associate in the project MODELAGE lead by Esther Pueyo. In 2016 she was awarded an ARAID researcher position and since 2017, she is a faculty research member of the BSICoS group.

Her current research activities comprise the understanding of human cardiac aging and other cardiac conditions from in vitro modelling using iPSC and genome engineering and the integration of the experimental data in computational biology.

PUBLICATIONS
72 entries « 2 of 3 »

2023

Conferences

Sánchez-Barat, M; Hernández-Bellido, N; Postigo, A; Ordovás, L; Hernández-Ainsa, S

Towards post-ischemic cardiac regeneration with microRNA therapy and customized DNA-based nanostructures Conference

12º Congreso bianual de la Sociedad Española de Terapia Génica y Celular (SETGyC), Pamplona (Sapin), 2023.

BibTeX

Hernández-Ainsa, S; Postigo, A; Hernández-Bellido, N; Sánchez-Barat, M; Sarasa, L; Ordovás, L; del Barrio, J

Tailoring DNA-based nanostructures for the delivery of therapeutic agents Conference

XXXIX Reunión Bienal de Química, Zaragoza (Spain), 2023.

BibTeX

Sánchez-Barat, M; Hernández-Bellido, N; Postigo, A; Ordovás, L; Hernández-Ainsa, S

Development of customised DNA-based nanostructures to treat heart disease by gene therapy Conference

XXXIX Reunión Bienal de Química, Zaragoza (Spain), 2023.

BibTeX

Garrido-Huéscar, E; Verschuuren, M; Vandeweyer, L; Santander-Badules, H; Pueyo, E; Vos, W H De; Ordovás, L

High-content phenotypic profiling to advance the maturation state of human induced pluripotent stem cells derived cardiomyocytes Conference

Cellular Biology of the Heart & Myocardial Function (CBFH) Biennial meeting 2023, Naples (Italy), 2023.

BibTeX

Postigo, A; Hernández-Bellido, N; Sánchez-Barat, M; Orrite, C; Garrido-Huéscar, E; García-Mendívil, L; Pueyo, E; Ordovás, L; Hernández-Ainsa, S

Design of DNA-based nanocarriers for the delivery of microRNA therapies against cardiac dysfunction Conference

Cellular Biology of the Heart & Myocardial Function (CBFH) Biennial meeting 2023, Naples (Italy), 2023.

BibTeX

García-Mendívil, L; Hernández-Bellido, N; Sánchez-Barat, M; Pérez-Zabalza, M; Garrido-Huéscar, E; Vallejo-Gil, J M; Matamala-Adell, M; Sorribas-Berjón, J F; Bellido‑Morales, J A; Vaca‑Núñez, A S; Ballester-Cuenca, C; Verfaillie, C M; Pueyo, E; Ordovás, L

Progerin is an unlikely contributor to natural cardiac aging, but promotes age-related phenotypes in vitro Conference

Cellular Biology of the Heart & Myocardial Function (CBFH) Biennial meeting 2023, Naples (Italy), 2023.

BibTeX

Sánchez-Barat, M; Hernández-Bellido, N; Postigo, A; Hernández-Ainsa, S; Ordovás, L

Exploiting the therapeutic potential of microRNAs and DNA nanotechnology to create novel cardioregenerative treatments Conference

Cellular Biology of the Heart & Myocardial Function (CBFH) Biennial meeting 2023, Naples (Italy), 2023.

BibTeX

Hernández-Bellido, N; Ramos-Marquès, E; Hernández-Vicente, A; García-Mendívil, L; Santander-Badules, H; Garrido-Huéscar, E; Sánchez-Barat, M; Garatachea, N; Kohler, R; Pueyo, E; Ordovás, L

Identification of biological age indicators as potential predictors of physical and cardiac-related conditions Conference

Cellular Biology of the Heart & Myocardial Function (CBFH) Biennial meeting 2023, Naples (Italy), 2023.

BibTeX

Vandeweyer, L; Garrido-Huéscar, E; Akdeniz, D; Loeys, B; Ordovás, L; Vos, W H De

Nuclear envelope stress in cardiac laminopathy patient derived Conference

Joint Meeting of the BeSSCR & RBSCDB on cell plasticity, Brussels (Belgium), 2023.

BibTeX

2022

Journal Articles

García-Mendívil, L; Pérez-Zabalza, M; Mountris, K; Duwé, S; Smisdom, N; Pérez, M; Luján, L; Wolfs, E; Driesen, R B; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Vázquez-Sancho, M; Matamala-Adell, M; Sorribas-Berjón, J F; Bellido-Morales, J A; Mancebón-Sierra, F J; Vaca-Núñez, A S; Ballester-Cuenca, C; Oliván-Viguera, A; Diez, E; Ordovás, L; Pueyo, E

Analysis of age-related left ventricular collagen remodeling in living donors: implications in arrhythmogenesis Journal Article

In: iScience, 2022.

Links | BibTeX

Conferences

García-Mendívil, L; Hernández-Bellido, N; Sánchez-Barat, M; Pérez-Zabalza, M; Garrido-Huéscar, E; Oliveros, J C; Torres-Pérez, R; Ramos-Marqués, E; Pueyo, E; Ordovás, L

Envejecimiento cardíaco humano: transcriptómica y desarrollo de modelos celulares Conference

II Congreso Anual de Estudiantes de Doctorado (CAED), Universidad Miguel Hernández, Elche, 2022.

BibTeX

García-Mendívil, L; Pérez-Zabalza, M; Mountris, K M; Mancebón-Sierra, F J; Vaca-Núñez, A S; Duwé, S; Ordovás, L; Pueyo, E

Caracterización del remodelado del colágeno asociado a la edad en el ventrículo izquierdo humano de donantes vivos y sus implicaciones en la generación de arritmias Conference

XI Jornada de Jóvenes Investigadores del I3A, 2022.

Links | BibTeX

Garrido-Huéscar, E; García-Mendivil, L; Hernández-Bellido, N; Sánchez-Barat, M; Pérez-Zabalza, M; Pueyo, E; Ordovás, L

Development of new human models to determine age related cardiotoxicity of drugs Conference

Stem cells and stem cell models in disease & health (SCMiDH), Hasselt, Belgium, 2022.

Links | BibTeX

Garrido-Huéscar, E; Ordovás, L; Pueyo, E

Development of new computational models to evaluate age-related drugs cardiotoxicity Conference

XI Jornada de Jóvenes Investigadores del Instituto de Investigación en Ingeniería de Aragón (I3A), Zaragoza, Spain, 2022.

Links | BibTeX

Garrido-Huéscar, E; Ordovás, L; Pueyo, E

Development of new human models to determine age-related cardiotoxicity of drugs Conference

I ipIBA Day, Zaragoza, Spain, 2022.

BibTeX

Garrido-Huéscar, E; Ordovás, L; Pueyo, E

Development of new human models to determine age-related cardiotoxicity of drugs Conference

Frontiers in CardioVascular Biomedicine (FCVB), Budapest, Hungría, 2022.

BibTeX

Garrido-Huéscar, E; Ordovás, L; Pueyo, E

Human cardiac models for investigation of age-related cardiotoxic effects of drug compounds Conference

XV CIBER-BBN Annual Conference, Valencia, Spain, 2022.

BibTeX

Hernández-Bellido, N; Postigo, A; Orrite, C; Garrido-Huéscar, E; García-Mendivil, L; Pueyo, E; Hernández-Ainsa, S; Ordovás, L

Terapias cardiacas avanzadas con microRNAs basadas en nanoestructuras de DNA Conference

XI Jornada de Jóvenes Investigadores, Zaragoza, Spain, 2022.

Links | BibTeX

Hernández-Bellido, N; Postigo, A; Orrite, C; Garrido-Huéscar, E; García-Mendivil, L; Pueyo, E; Hernández-Ainsa, S; Ordovás, L

Towards advanced cardiac miRNA therapies through DNA-based nanostructures Conference

Frontiers in CardioVascular Biomedicine (FCVB), Budapest, Hungría, 2022.

Links | BibTeX

Hernández-Bellido, N; Postigo, A; Orrite, C; Garrido-Huéscar, E; García-Mendivil, L; Pueyo, E; Hernández-Ainsa, S; Ordovás, L

Terapias cardiacas avanzadas con microRNAs basadas en nanoestructuras de DNA Conference

I iPIBA Day, Zaragoza, Spain, 2022.

BibTeX

Hernández-Bellido, N; Köhler, R; Ordovás, L

MicroRNAs cardiacos en envejecimiento: Dianas terapéuticas y biomarcadores Conference

I iPIBA Day, Zaragoza, Spain, 2022.

BibTeX

Postigo, A; Marín, P; Hernández-Bellido, N; Ordovás, L; Barrio, J; Hernández-Ainsa, S

Development of tailored DNA nanostructures for anticancer drug delivery Conference

XXXVIII Reunión Bienal RSEQ, Granada, España, 2022.

BibTeX

Postigo, A; Hernández-Bellido, N; Ordovás, L; Barrio, J; Hernández-Ainsa, S

DNA nanostructures customized for therapeutic delivery Conference

5th Spanish Conference on Biomedical Applications of Nanomaterials SBAN, Madrid, Spain, 2022.

BibTeX

Postigo, A; Hernández-Bellido, N; Ordovás, L; del Barrio, J; Hernández-Ainsa, S

DNA nanostructures customized for therapeutic delivery Conference

Spanish Conference on Biomedical Applications of Nanomaterials (SBAN), Madrid, Spain, 2022.

BibTeX

Garrido-Huéscar, E; García-Mendívil, L; Hernández-Bellido, N; Sánchez-Barat, M; Pérez-Zabalza, M; Pueyo, E; Ordovás, L

Development of new human models to determine age-related cardiotoxicity of drugs Conference

Stem Cells and Stem Cell Models in Disease and Health (SCMIDH), Hasselt, Belgium, 2022.

BibTeX

Ordovás, L

Human-based in vitro and in silico tools: models for cardiac ageing and nanotherapy development Conference

Stem Cells and Stem Cell Models in Disease and Health (SCMIDH), Hasselt, Belgium, 2022.

BibTeX

2021

Journal Articles

Ramos-Marquès, E; García-Mendívil, L; Pérez-Zabalza, M; Santander-Badules, H; Srinivasan, S; Oliveros, J C; Torres-Pérez, R; Cebollada, A; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Vázquez-Sancho, M; Matamala-Adell, M; Sorribas-Berjón, J F; Bellido-Morales, J A; Mancebón-Sierra, F J; Vaca-Núñez, A S; Ballester-Cuenca, C; Jiménez-Navarro, M; Villaescusa, J M; Garrido-Huéscar, E; Segovia-Roldán, M; Oliván-Viguera, A; Gómez-González, C; Muñiz, G; Diez, E; Ordovás, L; Pueyo, E

Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution Journal Article

In: Aging Cell, vol. 00:e13383, pp. 1-16, 2021.

Links | BibTeX

García-Mendívil, L; Mediano, D; Hernaiz, A; Sanz, D; Vázquez, F; Marín, B; López, O; Otero, A; Badiola, J; Zaragoza, P; Ordovás, L; Bolea, R; Martín, I

Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons Journal Article

In: Animals, vol. 11, no. 1137, 2021.

Links | BibTeX

Conferences

Pérez, M; García-Mendívil, L; Mountris, K; Smisdom, N; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Matamala-Adell, M; Vázquez-Sancho, M; Mancebón-Sierra, F Javier; Vaca-Núñez, A Sebastián; Ballester-Cuenca, C; Olivan-Viguera, A; Ordovás, L; Pueyo, E

Age-associated changes in fibrosis amount and spatial organization and its effects on human ventricular electrophysiology Conference

Proceedings of the XLVII International Conference on Computing in Cardiology, Brno, Czech Republic, 2021.

Links | BibTeX

García-Mendívil, L; Smisdom, N; Duwe, S; Mountris, K; Srinivasan, S; Pérez, M; Luján, L; Wolfs, E; Driesen, R B; Olivan-Viguera, A; Vallejo-Gil, J M; Fresneda-Roldán, P C; Fañanás-Mastral, J; Vázquez-Sancho, M; Matamala-Adell, M; Sorribas-Berjón, F; Ballester-Cuenca, C; Diez, E; Ordovás, L; Pueyo, E

Caracterización del remodelado cardiaco asociado a la edad en el ventrículo izquierdo humano Conference

Primer congreso anual de estudiantes de doctorado de la Universidad Miguel Hernández. Comunicación oral, 2021.

BibTeX

72 entries « 2 of 3 »