Faculty Member
Call: +34 876 555478
Email: minchole@unizar.es
Address: Campus Río Ebro, Edificio I+D, Lab 6.1.08, C/ Mariano Esquillor, s/n – 50018 Zaragoza (Spain)
ABOUT ME
Ana Mincholé graduated in Physics from the University of Zaragoza, Spain in 2002. She also obtained an MSc with distinction at Chalmers University of Technology, Gothenburg, Sweden, in the MSc program “Nanoscale Physics and Engineering”. She then started a PhD in Biomedical Engineering at the Communication Technology Group at the University of Zaragoza, Spain supervised by Prof. Pablo Laguna. Her PhD focused on the analysis of the electrocardiographic signal and the development of novel ECG biomarkers for the stratification of arrhythmic risk. During her PhD, she conducted research visits to the Laboratory for Biomedical Computer Systems and Imaging at the University of Ljubljana, Slovenia, with Prof. Franc Jager, and to the Argentinian Institute of Mathematics, CONICET with Dr Pedro Arini and Dr Marcelo Risk. After her PhD and a short postdoc experience in the European preDiCt project at the University of Oxford, she was awarded a Marie Curie Intra-European Fellowship for Career Development and joined Prof. Blanca Rodriguez’ group at the Department of Computer Science at the University of Oxford, UK. After the fellowship, she continued working at the University of Oxford holding the position of Senior Research Associate until 2019. Then, she moved to the University of Zaragoza to join the Multiscale in Mechanical and Biological Engineering group within the European PRIMAGE project where she applied her expertise in multiscale modelling and simulation and high-performance computing to model tumour growth. In 2020, she was awarded a Ramón y Cajal Senior Research Fellowship from the Spanish Ministry of Science and Innovation and joined the Biomedical Signal Interpretation and Computational Simulation (BSICoS) group at the University of Zaragoza in 2021.
Her research interests include the development and evaluation of synergistic data-driven approaches where modelling and simulation are used to integrate biomedical data at different scales in the investigation of cardiac pathological conditions. This is in line with her expertise in the combination of computational modelling and simulation of physiological processes, biomedical signal analysis and machine learning techniques to stratify risk either drug-induced or due to pathological conditions.
PUBLICATIONS
2014
Conferences
Valenza, G; Orini, M; Citi, L; Minchole, A; Pueyo, E; Laguna, P; Barbieri, R
Assessing Instantaneous QT Variability dynamics within a Point-Process Nonlinear Framework Conference
8th CONFERENCE OF THE EUROPEAN STUDY GROUP ON CARDIOVASCULAR OSCILLATIONS, 2014.
@conference{Valenza_conf2014,
title = {Assessing Instantaneous QT Variability dynamics within a Point-Process Nonlinear Framework},
author = {G Valenza and M Orini and L Citi and A Minchole and E Pueyo and P Laguna and R Barbieri},
url = {https://drive.google.com/file/d/1WwrDj1V_CuiIL0q_S7gnKNcSsrIYOd1o/view},
year = {2014},
date = {2014-01-01},
booktitle = {8th CONFERENCE OF THE EUROPEAN STUDY GROUP ON CARDIOVASCULAR OSCILLATIONS},
pages = {67-68},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Valenza, G; Orini, M; Citi, L; Minchole, A; Pueyo, E; Laguna, P; Barbieri, R
36nd Annual International Conference of the IEEE EMBS, 2014.
@conference{Valenza_conf2014b,
title = {Assessing Real-Time RR-QT Frequency-Domain Measures of Coupling and Causality through Inhomogeneous Point-Process Bivariate Models},
author = {G Valenza and M Orini and L Citi and A Minchole and E Pueyo and P Laguna and R Barbieri},
url = {https://drive.google.com/file/d/15_4IKWP_Luw4XfI1XRm15qJnhA1q_xT1/view},
year = {2014},
date = {2014-01-01},
booktitle = {36nd Annual International Conference of the IEEE EMBS},
pages = {6475-6478},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Cruces, P D; Bonomini, M P; Teperino, M J; Mincholé, A; Laguna, P; Arini, P D
Normal Ventricular Repolarization Dispersion Range with Abrupt Heart Rate Changes Conference
XLI International Conference on Computing in Cardiology, 2014.
@conference{Cruces_conf2014,
title = {Normal Ventricular Repolarization Dispersion Range with Abrupt Heart Rate Changes},
author = {P D Cruces and M P Bonomini and M J Teperino and A Mincholé and P Laguna and P D Arini},
url = {https://drive.google.com/file/d/1pvoKQ_wYPIQJKgpAaWfQsBe6ldcIhBLF/view},
year = {2014},
date = {2014-01-01},
booktitle = {XLI International Conference on Computing in Cardiology},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
2013
Journal Articles
Lázaro, J; Gil, E; Bailón, R; Mincholé, A; Laguna, P
Deriving Respiration from Photoplethysmographic Pulse Width Journal Article
In: Medical & Biological Engineering & Computing, vol. 51, pp. 233-242, 2013.
@article{Lazaro2013,
title = {Deriving Respiration from Photoplethysmographic Pulse Width},
author = {J Lázaro and E Gil and R Bailón and A Mincholé and P Laguna},
url = {https://drive.google.com/file/d/19qzUDO20fjKfokbBg0RrEhj_ItlLeheY/view},
doi = {10.1007/s11517-012-0954-0},
year = {2013},
date = {2013-01-01},
journal = {Medical & Biological Engineering & Computing},
volume = {51},
pages = {233-242},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Lázaro, J; Gil, E; Bailón, R; Mincholé, A; Laguna, P
Erratum to: Deriving respiration from photoplethysmographic pulse width Journal Article
In: Medical & Biological Engineering & Computing, vol. 51, pp. 243, 2013.
@article{Lazaro2013e,
title = {Erratum to: Deriving respiration from photoplethysmographic pulse width},
author = {J Lázaro and E Gil and R Bailón and A Mincholé and P Laguna},
url = {https://drive.google.com/file/d/1KlLTllFuZjl5b1QmuzjfU2–uJUcdB9I/view},
doi = {10.1007/s11517-012-0997-2},
year = {2013},
date = {2013-01-01},
journal = {Medical & Biological Engineering & Computing},
volume = {51},
pages = {243},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Conferences
Ramírez, J; Mincholé, A; Bolea, J; Laguna, P; Pueyo, E
XL International Conference on Computing in Cardiology, Zaragoza, Spain, 2013.
@conference{Ramirez_conf2013,
title = {Prediction of Sudden Cardiac Death in Chronic Heart Failure Patients by Analysis of Restitution Dispersion},
author = {J Ramírez and A Mincholé and J Bolea and P Laguna and E Pueyo},
url = {https://drive.google.com/file/d/1QdIt_avEVyLgmZNexoFdoxMGY3dlqdwV/view},
year = {2013},
date = {2013-01-01},
booktitle = {XL International Conference on Computing in Cardiology},
pages = {1-4},
address = {Zaragoza, Spain},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Teperino, M J; Cruces, P D; Mincholé, A; Laguna, P; Bonomini, M P; Arini, P D
XV Reunion de Trabajo en Procesamiento de la Información y Control, 2013.
@conference{Teperino_conf2013,
title = {Dynamic response of temporal and spatial ventricular repolarization dispersion indices during abrupt heart rate changes},
author = {M J Teperino and P D Cruces and A Mincholé and P Laguna and M P Bonomini and P D Arini},
url = {https://drive.google.com/file/d/1OJyfDthe9zK6Hqle44OSNbdIVcaT2fbu/view},
year = {2013},
date = {2013-01-01},
booktitle = {XV Reunion de Trabajo en Procesamiento de la Información y Control},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
2012
Conferences
Minchole, A; Zacur, E; Pueyo, E; Laguna, P
Efficient characterization of repolarization adaptation to heart rate changes Conference
BSI12, 2012.
@conference{Minchole_conf20121,
title = {Efficient characterization of repolarization adaptation to heart rate changes},
author = {A Minchole and E Zacur and E Pueyo and P Laguna},
url = {https://drive.google.com/file/d/1zNDh-GnME-pO9tI2HH5d5ofvr1Ua1t29/view},
year = {2012},
date = {2012-01-01},
booktitle = {BSI12},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Minchole, A; Bueno-Orovio, A; Laguna, P; Pueyo, E; Rodriguez, B
BSI12, 2012.
@conference{Minchole_conf20122,
title = {A novel ECG-based biomarker quantifying apd restitution dispersion improves risk stratification following sotalol administration},
author = {A Minchole and A Bueno-Orovio and P Laguna and E Pueyo and B Rodriguez},
url = {https://drive.google.com/file/d/1ZtKxhvmGHXRR2L1EuDQrtyBY5quf4-Hr/view},
year = {2012},
date = {2012-01-01},
booktitle = {BSI12},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Ramírez, J; Mincholé, A; Laguna, P; Pueyo, E
Characterization of Cardiac Repolarization Response to Heart Rate Changes Provoked by a Tilt Test Conference
XXXIX International Conference on Computing in Cardiology, Kracow, Poland, 2012.
@conference{Ramirez_conf2012c,
title = {Characterization of Cardiac Repolarization Response to Heart Rate Changes Provoked by a Tilt Test},
author = {J Ramírez and A Mincholé and P Laguna and E Pueyo},
url = {https://drive.google.com/file/d/1v9OAJsY7ecizCnCadRMBSpN_QP3Oa-Xh/view},
year = {2012},
date = {2012-01-01},
booktitle = {XXXIX International Conference on Computing in Cardiology},
pages = {673-676},
address = {Kracow, Poland},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Ramírez, J; Mincholé, A; Laguna, P; Pueyo, E
Proceedings XXX Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB), 2012, ISBN: 10:84-616-2147-6; 13:978-84-616-2147-7.
@conference{Ramirez_conf2012b,
title = {Caracterización de la Respuesta de la Repolarización a Cambios en el Ritmo Cardiaco Provocados por una Prueba de “Tilt”},
author = {J Ramírez and A Mincholé and P Laguna and E Pueyo},
url = {https://drive.google.com/file/d/18jUXG81Gksv39Kn65rSzh1bR1yTb3Iui/view},
isbn = {10:84-616-2147-6; 13:978-84-616-2147-7},
year = {2012},
date = {2012-01-01},
booktitle = {Proceedings XXX Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB)},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
2011
Journal Articles
Mincholé, A; Pueyo, E; Rodríguez, J F; Zacur, E; Doblaré, M; Laguna, P
Quantification of Restitution Dispersion from the Dynamic Changes of the T wave peak to end, measured at the Surface ECG Journal Article
In: IEEE Transactions Biomedical Engineering, vol. 58, no. 5, pp. 1172-1182, 2011.
@article{Minchole2011,
title = {Quantification of Restitution Dispersion from the Dynamic Changes of the T wave peak to end, measured at the Surface ECG},
author = {A Mincholé and E Pueyo and J F Rodríguez and E Zacur and M Doblaré and P Laguna},
url = {https://drive.google.com/file/d/1oW1QEWniJ5LPrnDTIL8jL0M2mek2wrDq/view},
doi = {10.1109/TBME.2010.2097597},
year = {2011},
date = {2011-01-01},
journal = {IEEE Transactions Biomedical Engineering},
volume = {58},
number = {5},
pages = {1172-1182},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Conferences
Mincholé, A; Sörnmo, L; Laguna, P
ECG-based detection of body position changes using a Laplacian noise model Conference
33nd Annual International Conference of the IEEE EMBS, Boston, USA, 2011.
@conference{Minchole_conf2011,
title = {ECG-based detection of body position changes using a Laplacian noise model},
author = {A Mincholé and L Sörnmo and P Laguna},
url = {https://drive.google.com/file/d/1v4lcq8Vth0lwxnmEAkR9iULTjPBcCHcM/view},
year = {2011},
date = {2011-01-01},
booktitle = {33nd Annual International Conference of the IEEE EMBS},
pages = {6931-6934},
address = {Boston, USA},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
PhD Theses
Mincholé, A
Zaragoza University, 2011.
@phdthesis{Minchole_Thesis,
title = {Automatic detection of ischemia in Holter recordings and search for new risk markes from the electrocardiographic signal},
author = {A Mincholé},
url = {https://drive.google.com/file/d/1RMkia7Ek5vXiEZEcPzcmDtAPiBkWhYje/view},
year = {2011},
date = {2011-01-01},
urldate = {2011-01-01},
school = {Zaragoza University},
keywords = {},
pubstate = {published},
tppubtype = {phdthesis}
}
2010
Journal Articles
Mincholé, A; Jager, F; Laguna, P
Discrimination Between Ischemic and Artifactual ST Segment Events in Holter Recordings Journal Article
In: Biomedical signal processing and control, vol. 5, pp. 21-31, 2010.
@article{Minchole2010,
title = {Discrimination Between Ischemic and Artifactual ST Segment Events in Holter Recordings},
author = {A Mincholé and F Jager and P Laguna},
url = {https://drive.google.com/file/d/11GcDKpPNwu13Yr5sJVjDzRD3O_X7wr4N/view},
doi = {10.1016/j.bspc.2009.09.001},
year = {2010},
date = {2010-01-01},
journal = {Biomedical signal processing and control},
volume = {5},
pages = {21-31},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Conferences
Mincholé, A; Pueyo, E; Rodriguez, J F; Zacur, E; Doblaré, M; Laguna, P
Evaluation of a Method for Quantification of Restitution Dispersion from the surface ECG Conference
XXXVII International Conference on Computers in Cardiology, Belfast, UK, 2010.
@conference{Minchole_conf2010c,
title = {Evaluation of a Method for Quantification of Restitution Dispersion from the surface ECG},
author = {A Mincholé and E Pueyo and J F Rodriguez and E Zacur and M Doblaré and P Laguna},
url = {https://drive.google.com/file/d/1T6AQAZsXX5-3guJ3X6K27_LWfb1At6J1/view},
year = {2010},
date = {2010-01-01},
booktitle = {XXXVII International Conference on Computers in Cardiology},
pages = {773-776},
address = {Belfast, UK},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Mincholé, A; Pueyo, E; Laguna, P
Dispersion of APD restitution quantified from the surface ECG Conference
35th Research and Technology transfer in computerized electrocardiology, 2010.
@conference{Minchole_conf2010b,
title = {Dispersion of APD restitution quantified from the surface ECG},
author = {A Mincholé and E Pueyo and P Laguna},
url = {https://drive.google.com/file/d/1s_qWuyRTmgW2ULYRNLis8LH_U-bYMx1a/view},
year = {2010},
date = {2010-01-01},
booktitle = {35th Research and Technology transfer in computerized electrocardiology},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
2009
Conferences
Mincholé, A; Pueyo, E; Laguna, P
Diferencias Transmurales en la adaptación a cambios del ritmo cardiaco medidas sobre el ECG Conference
XXVII Congreso Anual de la Sociedad española de Ingeniería Biomédica, 2009.
@conference{Minchole_c209,
title = {Diferencias Transmurales en la adaptación a cambios del ritmo cardiaco medidas sobre el ECG},
author = {A Mincholé and E Pueyo and P Laguna},
url = {https://drive.google.com/file/d/1a2kI_akBaZah4zfNn475taOe47q2Itn3/view},
year = {2009},
date = {2009-01-01},
booktitle = {XXVII Congreso Anual de la Sociedad española de Ingeniería Biomédica},
pages = {597-600},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Orini, M; Bailón, R; Mincholé, A; Mainardi, L; Laguna, P
XXVII Congreso Anual de la Sociedad española de Ingeniería Biomédica, 2009.
@conference{Orini_c209,
title = {Metodología para el seguimiento de las dinámicas cardiovasculares a través de la coherencia tiempo-frecuencia},
author = {M Orini and R Bailón and A Mincholé and L Mainardi and P Laguna},
url = {https://drive.google.com/file/d/1MosvrVl1e4EBubFt67BjEa4ca4uMtZ5l/view},
year = {2009},
date = {2009-01-01},
booktitle = {XXVII Congreso Anual de la Sociedad española de Ingeniería Biomédica},
pages = {629-632},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Mincholé, A; Pueyo, E; Laguna, P
XXXVI Ann. Conf. Computers in Cardiology, Park City, 2009.
@conference{Minchole_c309,
title = {Transmural Differences in Rate Adaptation of Repolarization Duration Quantified from ECG Repolarization Interval Dynamics},
author = {A Mincholé and E Pueyo and P Laguna},
url = {https://drive.google.com/file/d/1Xh6sXFUfUm8bBiSyUwXm6tIvUCNxagV2/view},
year = {2009},
date = {2009-01-01},
booktitle = {XXXVI Ann. Conf. Computers in Cardiology},
pages = {597-600},
address = {Park City},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Orini, M; Bailón, R; Mainardi, L; Mincholé, A; Laguna, P
XXXVI Ann. Conf. Computers in Cardiology, Park City, 2009.
@conference{Orini_c309,
title = {Continuous Quantification of Spectral Coherence Using Quadratic Time-Frequency Distributions: Error Analysis and Application},
author = {M Orini and R Bailón and L Mainardi and A Mincholé and P Laguna},
url = {https://drive.google.com/file/d/1oOenbkZpwEXVyUOC7uAHjfpMDGXfzsVv/view},
year = {2009},
date = {2009-01-01},
booktitle = {XXXVI Ann. Conf. Computers in Cardiology},
pages = {681-684},
address = {Park City},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
2007
Conferences
Mincholé, A; Laguna, P
Discriminación entre isquemia de demanda y de suministro en registros Holter Conference
XXV Congreso Anual de la Sociedad española de Ingeniería Biomédica, 2007.
@conference{Minchole_c107,
title = {Discriminación entre isquemia de demanda y de suministro en registros Holter},
author = {A Mincholé and P Laguna},
url = {https://drive.google.com/file/d/1-SPdhR8VzT1L5BOuMTjugL9g8awKFCeR/view},
year = {2007},
date = {2007-01-01},
booktitle = {XXV Congreso Anual de la Sociedad española de Ingeniería Biomédica},
pages = {326-329},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Mincholé, A; Jager, F; Laguna, P
Discrimination between Demand and Supply Ischemia Episodes in Holter Recordings Conference
29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC07), Lyon, 2007.
@conference{Minchole_c307,
title = {Discrimination between Demand and Supply Ischemia Episodes in Holter Recordings},
author = {A Mincholé and F Jager and P Laguna},
url = {https://drive.google.com/file/d/1rU1yTZex8q0fY6yfRsBz9-tiivYhfflJ/view},
year = {2007},
date = {2007-01-01},
booktitle = {29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC07)},
pages = {2579-2582},
address = {Lyon},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
2006
Conferences
Mincholé, A; Martínez, J P; Arini, P; Risk, M; Laguna, P
Cambios en la repolarización cardiaca generados por la maniobra de Valsalva y medidos sobre el ECG Conference
XXIV Congreso Anual de la Sociedad Española de Ingeniería Biomédica, 2006.
@conference{Minchole_c106,
title = {Cambios en la repolarización cardiaca generados por la maniobra de Valsalva y medidos sobre el ECG},
author = {A Mincholé and J P Martínez and P Arini and M Risk and P Laguna},
url = {https://drive.google.com/file/d/1MG75q6NwFZVzyoOqKBzBcE7Na0yoNWou/view},
year = {2006},
date = {2006-01-01},
booktitle = {XXIV Congreso Anual de la Sociedad Española de Ingeniería Biomédica},
pages = {29-32},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Mincholé, A; Martínez, J P; Arini, P; Risk, M; Laguna, P
T Wave Width Alterations during Valsalva Maneuvers in Diabetic Patients Conference
Computers in Cardiology 2006, 2006.
@conference{Minchole_c206,
title = {T Wave Width Alterations during Valsalva Maneuvers in Diabetic Patients},
author = {A Mincholé and J P Martínez and P Arini and M Risk and P Laguna},
url = {https://drive.google.com/file/d/1auPnroj9S0ls-3DEcyJF9ymHjFw-kTvL/view},
year = {2006},
date = {2006-01-01},
booktitle = {Computers in Cardiology 2006},
pages = {709-712},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
2005
Conferences
Mincholé, A; Skarp, B; Jager, F; Laguna, P
XXIII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, 2005.
@conference{Minchole_c205,
title = {Evaluación de un detector de isquemia basado en la raíz cuadrática media sobre la base de datos LTST con cancelación de cambios posturales},
author = {A Mincholé and B Skarp and F Jager and P Laguna},
url = {https://drive.google.com/file/d/1goB7HOOsoIpfHGd_AzlKRkNU71L9MYJO/view},
year = {2005},
date = {2005-01-01},
booktitle = {XXIII Congreso Anual de la Sociedad Española de Ingeniería Biomédica},
pages = {121-124},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Mincholé, A; Skarp, B; Laguna, P
XXXII Ann. Conf. Computers in Cardiology, Lyon, 2005.
@conference{Minchole_c105,
title = {Evaluation of a Root Mean Squared Based Ischemia Detector on the Long-Term ST Database with Body Position Change Cancellation},
author = {A Mincholé and B Skarp and P Laguna},
url = {https://drive.google.com/file/d/1gvlnZEun4AhlmHmHsiv9ToV29a3W0sz7/view},
year = {2005},
date = {2005-01-01},
booktitle = {XXXII Ann. Conf. Computers in Cardiology},
pages = {853-856},
address = {Lyon},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}